Kavli Institute for Nanoscience Discovery, University of Oxford
@kavlioxford.bsky.social
Catalysing discovery by bringing the physical sciences into the cell.
Join Professor Philipp Kukura FRS for the Clifford Paterson Prize Lecture on 9 February. He will describe the development of mass photometry, a method that measures the mass of molecules and viruses: royalsociety.org/science-even... @kavlioxford.bsky.social
Elena Seiradake @kavlioxford.bsky.social and co-workers @ox.ac.uk @renalucl.bsky.social present crystal structures of the CD177 ectodomain and a CD177-PR3 complex, revealing a major autoantibody epitope. -> link.springer.com/article/10.1...
Dive into a world where physicists, chemists, neuroscientists & engineers unite to explore the mysteries of the molecular realm & beyond with @kavlioxford.bsky.social! See how they're shaping the future of nanoscience now. @biophysicalsoc.bsky.social #bps2026 youtu.be/BsmliX3ILig
Where Curiosity Sparks Collaboration | The Kavli Institute for Nanoscience Discovery at Oxford
YouTube video by WebsEdgeScience
youtu.be
Structure-guided design of a PfCyRPA-based #vaccine against blood-stage #malaria ➡️ doi.org/10.1038/s44321-026-00376-x By N. Alam, @parasitematt.bsky.social and colleagues @ox.ac.uk @kavlioxford.bsky.social
SMART and @kavlioxford.bsky.social @kavlifoundation.org are teaming up, signing a Memorandum of Understanding to launch collaboration. The partnership will focus on infectious diseases, membrane biology, antimicrobial resistance. It will also support researcher exchanges between Shenzhen and Oxford.
To Boldly Go: Magnetic microrobot system of drug-loaded nanoparticles protected by pH-responsive coating - makes a delivery in pig stomach 📹 Rujie Sun, Junyoung Kim, Yixuan Leng et al @imperialcollegeldn.bsky.social @kavlioxford.bsky.social in @science.org Advances ➡️ bpod.org.uk/archive/2026...
Delighted to share our review on how those malaria parasites get into our blood cells and how we might stop them. rdcu.be/eGnUl
Erythrocyte invasion in malaria: from molecular mechanisms to rational vaccines
Nature Reviews Microbiology - If erythrocyte invasion is blocked during the blood stage of infection by Plasmodium parasites, malaria can be prevented. In this Review, structural insights on...
rdcu.be
Congratulations to Mootaz Salman on receiving the Bayliss–Starling Prize Lecture 2025 from The Physiological Society! Read more 👉 kavli.web.ox.ac.uk/article/moot...
Mootaz Salman Awarded the Bayliss-Starling Prize Lecture 2025 by The Physiological Society
kavli.web.ox.ac.uk
#MeetTheResearcher We’re pleased to introduce Amy Roberts this week from the Seiradake Group. Amy is a #DPhil candidate currently in her second year of study. Her research is generously supported by the Margaret Pelly-Carys Bannister Scholarship from Somerville College.
#KavliOxford's August publications are now out! lnkd.in/eC4tq9Te
#MeetTheResearcher Happy to introduce Chitra Joshi this week! Chitra is a postdoc researcher in the Newstead Group working on the structural basis of metabolite and drug transport through solute carrier proteins (SLCs) in humans.
#MeetTheResearcher Introducing Tamiris Borges da Silva this week from the Becker Lab. Tamiris is a postdoctoral researcher developing induced human pluripotent stem cell (hiPSC) models and reporter lines to study human cerebellar development.
#TuesdayReads: Becky Carlyle et al develop and validate an ELISA to measure PKM in cerebrospinal fluid—linking elevated levels to accelerated cognitive decline in Alzheimer’s and highlighting PKM as a potential early biomarker. 🔗 www.degruyterbrill.com/document/doi...
Immunoassay for pyruvate kinase M1/2 as an Alzheimer’s biomarker in CSF
Alzheimer’s disease (AD) is characterized by amyloid-beta plaques and tau tangles in the brain, but these markers alone do not predict disease progression. The intersection of these pathologies with o...
degruyterbrill.com
#TuesdayReads: Struwe Group et al reveal the structure of a key Trypanosoma cruzi enzyme, TcPOP, and show its potential as a Chagas disease vaccine target through invasion-blocking immune responses. 🔗 www.nature.com/articles/s41... #ChagasDisease #VaccineResearch #CryoEM #ParasiteBiology
Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOP - Nature Communications
Chagas disease, caused by Trypanosoma cruzi, lacks an effective vaccine. Here, the authors report the cryo-EM structure of TcPOP, a potential vaccine antigen, in open and closed states and validate it...
nature.com
Carol Robinson on Desert Island Discs - have a listen friends: www.bbc.co.uk/sounds/play/... An inspirational scientist & friend. An example of combining scientific excellence, courage, hard work and really importantly; kindness. (Yes I’m biased, but it’s true nevertheless) @kavlioxford.bsky.social
Desert Island Discs - Professor Dame Carol Robinson, scientist - BBC Sounds
Dame Carol Robinson, scientist, shares the soundtrack of her life with Lauren Laverne.
bbc.co.uk
🔬 #MeetTheResearcher This week we’re spotlighting Jana Joha, a DPhil candidate in the Seiradake Group, who is investigating the molecular mechanisms behind a rare autoimmune condition: granulomatosis with polyangiitis (GPA) – an ANCA-associated vasculitis.
🎧 Professor Dame Carol Robinson joins BBCRadio4’s Desert Island Discs to reflect on her life and career through eight memorable tracks. From Pfizer at 16 to Professorship at Oxford. 📻 Listen from 10 Aug → www.bbc.co.uk/programmes/m... #DesertIslandDiscs #WomenInSTEM #MassSpec #KavliOxford
BBC Radio 4 - Desert Island Discs, 10/08/2025
Lauren Laverne invites her castaway guests to share the soundtrack of their lives.
bbc.co.uk
#TuesdayReads: Kapanidis Group et al present a single-molecule approach to study DNAzymes—revealing functional diversity and uncovering performance differences masked in bulk measurements, with implications for biosensing. 🔗 pubs.acs.org/doi/10.1021/...
Single-Molecule Imaging for Unraveling the Functional Diversity of 10–23 DNAzymes
DNA-based enzymes, also known as DNAzymes, have opened new opportunities for signal generation and amplification in several fields including biosensing. However, biosensor performance can be hampered ...
pubs.acs.org
#TuesdayReads: The Jagannath Group reviews the genetic and molecular workings of the circadian clock—highlighting how rhythm disruptions contribute to neurological disease and how targeting circadian mechanisms may offer new therapies. 🔗 www.sciencedirect.com/science/arti...
The molecular circadian clock: From fundamental mechanisms to therapeutic promise in neurological disorders
Circadian rhythms are intrinsic biological processes in all forms of life, governed by a molecular clock, organising physiological and behavioural cyc…
sciencedirect.com
#KavliOxford July publications are now out! Browse the full list here: kavli.web.ox.ac.uk/have-you-see...
#MeetTheResearcher Meet Jonathan Dye from the Struwe Lab! Jonathan is a #DPhil candidate researching the integrated characterisation of Lassa fever humoral immunity.
#TuesdayReads: In a multi-institutional collaboration, the Stephen Tucker & Simon Newstead Groups help reveal the structure of THIK-1, offering insights into its role in #neuroinflammation and therapeutic potential. 🔗 www.nature.com/articles/s41... #CryoEM #IonChannels #ALS #Alzheimers
Cryo-EM structure of the human THIK-1 K2P K+ channel reveals a lower Y gate regulated by lipids and anesthetics - Nature Structural & Molecular Biology
In this study, Rödström et al. use cryo-EM to reveal a range of structural features in THIK-1 K+ channel and demonstrate how these features define many functional properties of the channel, thus expan...
nature.com
#TuesdayReads: Draper Group et al reveal how disease tolerance to malaria develops after just one infection—reprogramming T cell responses to reduce inflammation without compromising memory. rupress.org/jem/article/... #Malaria #Immunology #DiseaseTolerance #TCellResponse @kavlifoundation.org
Plasmodium falciparum infection induces T cell tolerance that is associated with decreased disease severity upon re-infection | Journal of Experimental Medicine | Rockefeller University Press
Sandoval et al. show that a single malaria episode reprograms T cell activation to minimize cytotoxicity and injury during subsequent infections. This adap
rupress.org
There’s still time to apply for this brilliant opportunity to work with Dominika Gruszka Applications close on 1 August.
Kavli Institute for Nanoscience Discovery, University of Oxford@kavlioxford.bsky.social · last yr.🚨 The Gruszka Lab is hiring! We’re looking for a Researcher in Microscopy Image Analysis to join our team. 🔗 Know someone who might be interested? Share this post or tag them! 👉 Find out more and apply here: www.jobs.ac.uk/job/DNU476/r... @mplsoxford.bsky.social @oxfordphysics.bsky.social
#TuesdayReads: Molly Stevens et al introduce magnetic microrobots with programmable movement and high cargo capacity—offering a powerful platform for precision drug delivery and clinical translation. 🔗 www.science.org/doi/10.1126/... #Microrobots #PrecisionMedicine #Bioengineering #DrugDelivery
Permanent magnetic droplet–derived microrobots
Permanent magnetic droplet–derived microrobots have enhanced cargo loading and locomotion capabilities.
science.org
🥳 We are celebrating achieving a LEAF Gold award for the 3rd year in a row! 🥳Thanks to everyone for their support in adhering to more sustainable practices. A special thank you to Feodora Bertherat for her tireless efforts & the extra work she puts in to help us achieve this.
🌿 We’re delighted to share that Higgins Group at Kavli Oxford has been awarded a Gold LEAF Award! Led by lab manager Hannah Ivison, the team has taken impressive steps to reduce waste, improve efficiency, and build a more sustainable lab. One more Gold for #KavliOxford! ✨ tinyurl.com/ynceehdn
Higgins Group Awarded Gold LEAF Award for Sustainability Efforts
kavli.web.ox.ac.uk
🎉 Huge congratulations to Yohan Arman on successfully passing his DPhil viva on 25 July! His thesis explored antiviral drug discovery and vaccine quality. Well done, Yohan – a brilliant achievement! 👏 📸 With Profs. Nicole Zitzmann, Weston Struwe & Lutz Heide. #OxfordUni #DPhil #Biochemistry
Congratulations to Mootaz Salman on receiving the Geoffrey Burnstock Prize from the British Pharmacological Society! 🏆 Read more: kavli.web.ox.ac.uk/article/moot... @oxforddpag.bsky.social @ox.ac.uk @medsci.ox.ac.uk @kavlifoundation.org #Pharmacology #Neuroscience #AcademicExcellence
Mootaz Salman Awarded Geoffrey Burnstock Prize by the British Pharmacological Society
kavli.web.ox.ac.uk
