Bacterial ribosomes can synthesize proteins encoded within their own RNA - WOW🔥 Very elegant and inspiring work from Shura Mankin's lab - Congratulations! www.nature.com/articles/s41...

Rewiring the ribosome to translate proteins encoded in its own RNA - Nature

Bacterial ribosomes can synthesize proteins encoded within their own RNA.

nature.com

#microsky New preprint from the lab! Widespread immune systems protect bacteria against conjugative plasmids www.biorxiv.org/content/10.6... Kudos to the extremely talented lead author Ludovic Poiré! Key contributions by @francoisrousset.bsky.social and also help from C. Lesterlin/TacC lab. 🧵⬇️

Widespread immune systems protect bacteria against conjugative plasmids

Conjugative plasmids are a class of mobile genetic elements capable of efficient transfer between bacterial cells. Although they can introduce beneficial traits such as antibiotic resistance to recipi...

biorxiv.org

The preprint of my PhD paper is out ! We show cooperativity between various mobile elements which exploit the Xer machinery for lysogeny in Vibrio cholerae. Among them, the CTX bacteriophage, responsible toxigenic conversion. www.biorxiv.org/content/10.6...

Molecular interplay between Integrative Mobile Elements exploiting Xer drives the evolution of cholera pandemics

XerC and XerD are ubiquitous bacterial recombinases dedicated to chromosome dimer resolution. They add a crossover at a specific chromosomal site, dif, when activated by the FtsK cell division protein...

biorxiv.org

New preprint out on bioRxiv! www.biorxiv.org/content/10.6... Can conjugative plasmids be used to control plasmid and pathogen spread? Follow me down the rabbit hole that led to this story 🧵

A short research stay in 2019 (back in the pre-COVID era) at José R. Penadés lab turned into the third chapter of my PhD and today it finally sees the light.

Bacteria chromosomes contain Genomic Islands that provide virulence, antibiotic resistance, MGE-defence,... They transfer between cells, but the mechanism of most remains elusive. Here we explore the conjugative capacity of these mysterious Genomic Islands. www.biorxiv.org/content/10.6...

We've come full circle! I began my postdoctoral career by identifying the peptidyl deformylase gene. Today, we show that half of bacterial species harbor multiple PDF genes (up to 7, for always a single Met-tRNA transformylase), and while the role of these PDFs ... academic.oup.com/mbe/article/...

Unraveling the Prevalence and Multifaceted Roles of Accessory Peptide Deformylases in Bacterial Adaptation and Resistance

Abstract. Peptide deformylases (PDFs) are enzymes that are essential for bacterial viability and attractive targets for antibiotic development. Yet, despit

academic.oup.com

Our new paper is out in @narjournal.bsky.social We show that natural transformation enables bacteria to shuffle integron cassettes, boosting their phenotypic diversity. academic.oup.com/nar/article/... 1/5

Bacterial natural transformation drives cassette shuffling and simplifies recombination in chromosomal integrons

Abstract. Integrons act as biobanks of gene cassettes conferring functions crucial for bacterial defense, including protection against phages and antibioti

academic.oup.com

Our new paper maps the tRNA modification landscape in Vibrio cholerae! 💫 We describe differences from E. coli and discuss links to decoding of stress-related codons 🦠 Huge thanks to amazing co-authors and collaborators! @plos.org #rnasky #microsky #tRNAmodifications

The tRNA epitranscriptomic landscape and RNA modification enzymes in Vibrio cholerae

Author summary This study charts the first genome-wide map of transfer RNA (tRNA) modifications in the cholera pathogen, Vibrio cholerae, revealing how chemical marks on tRNAs shape translation and st...

journals.plos.org

Back in June, we welcomed #EESMicrobiology in Heidelberg 🦠 Today, we're happy to introduce you to the five best poster prize winners 👏 🏅 Kevin Debatisse 🏅 Elena López Rodríguez 🏅 Yorben Casters 🏅 Prunelle Carcassone 🏅 Lucía Pérez Learn more 👉 https://s.embl.org/EES25-06-blog

A 2-year postdoc position in my lab, under the supervision of P-Alex Kaminski, on Z-DNA phages and the benefit given by ZTGC DNA and the replication machinery, with attempt to create a Z based minireplicon research.pasteur.fr/en/job/a-two...

A two year post-doctoral position at the BacterialGenome Plasticity Unit starting October 1st - Research

research.pasteur.fr

📢 Postdoctoral research position A 2-year postdoctoral position on bacteriophages research is available at the Institut Pasteur in Paris in the Plasticity of the Genomes Unit. 🧐 Those interested can now send their applications!