Brandon (“YOU’RE WELCOME”) Greene
@keepitgreene.bsky.social
Biophysical chemist, redox biology, professor at UCSB, dad, husband, and part-time adventurer
The amount of arrogance in this interview is astounding. We will work had and it will work out. Don’t anthropomorphize, let me anthropomorphize. This is the best version, and it’s bad. open.spotify.com/s/Y2ttW46
Jensen Huang Thinks A.I. Alarmism Has Gone Too Far
The Ezra Klein Show · Episode
open.spotify.com
There needs to be better communication on this that puts the general public in the shoes of internet content publishers. Imagine a camera you didn’t consent to watching your every move as a plumber to train a robot with no compensation…
Mother Jones@motherjones.com · 2d agoAn AI executive warned that ChatGPT was built via “the largest theft of labor in human history.” That’s just one of the bombshell quotes we discovered through our OpenAI lawsuit.
Man, JVL channeling my inner thoughts @40:00 , whew that felt good. open.spotify.com/episode/27aX...
Jonathan V. Last: How Much Stupid Can We Possibly Take?
The Bulwark Daily · Episode
open.spotify.com
The vast majority of #chem AI/automation discussions seem to focus entirely on the ends (new molecules/materials) rather than the means that train the next generation of scientists. What are we training new synthetic chemists for in an automated lab that has a design-test-iterate machine loop?
I just want to know how the FIT him in the catering cart.
This is cool. www.pnas.org/doi/10.1073/...
Experimental evolution of cellular miniaturization reveals a putative mechanism for cell size evolution | PNAS
Cell volume, a key determinant of physiology, is maintained by cell size homeostasis. Large deviations from typical size are often harmful, yet cel...
pnas.org
Unknown redditor “the underlying purpose of AI is to allow wealth to access skill while removing from the skilled the access to wealth”
What a milk-toast article and missed opportunity. I truly wonder what audience the authors were targeting this towards. We need bolder scientific leaders. www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
I have long been saying that the American research universities need to stand up, stop squabbling with one another and present a unified stance on the future of academic research. The real question is, what is that stance... pubs.acs.org/bichaw/artic...
pubs.acs.org
This Platner saga is such a depressing ordeal. One thing that is under discussed (generally) is what is needed from Platner to “return to polite society.” We can’t just be scolds on the left. There has to be a clear path to some form of redemption.
The Graham Platner fiasco proves that the Democrat Party is far too tolerant of sexual predators. by Matt Gaetz, Roy Moore, Pete Hegseth, Jim Jordan, Dennis Hastert, Blake Farenthold, Trent Franks, Herman Cain, Cory Mills, Clarence Thomas, Brett Kavanaugh, and Donald J. Trump
The trump curse is real. Goes to the knicks game, they lose. Calls in a favor to swing the US team, they play their worst 90 mins all cup.
I have always been a huge fan of the field of quantitative mechanistic enzymology, trying to understand how the enzyme actually lowers the TS, but this requires knowing what the TS is like for the uncatalyzed rxn. Seems difficult for many of the enyzmes I currently and have worked on.
“But you have given us a birthday present beyond price--yourselves, your faith, your loyalty, and your love. We thank you with full and friendly hearts.” Gerald Ford on the bicentennial at a naturalization ceremony.
I've dreaded this for a long time, and it finally happened. Our 1.5 yo is going to be doing a lockdown drill at his daycare. We don't have to live like this. We don't. It is a choice. It hits different now, as a parent myself, and I am so angry and sad. Understand the necessity, but damn...
Great review of GREs from Andorfer and Drennan, check it out! pubs.acs.org/doi/full/10....
Nature’s Anaerobic Toolkit: Glycyl Radical Enzymes and Their Expanding Functional and Mechanistic Diversity
Nature has devised an array of enzymatic cofactors that enable challenging chemical transformations to occur on a time scale compatible with biological life. The glycyl radical enzyme (GRE) superfamily, for example, highlights the catalytic power of protein-based amino acid radicals. GREs utilize a persistent radical housed on the α-carbon of a C-terminally conserved glycine residue to accomplish diverse chemical reactions in anaerobic environments. This radical cofactor is post-translationally installed on the mature, folded protein by a radical S-adenosyl-L-methionine (RS) activating enzyme (GRE-AE; activase) specific to each GRE. The catalytic repertoire of GREs is diverse, spanning ribonucleotide reduction for DNA synthesis, acetyl-CoA formation in anaerobic primary metabolism, dehydration reactions in secondary metabolism, decarboxylation reactions in aromatic amino acid fermentation, and hydrocarbon activation in anaerobic bacteria, enabling their survival on crude oil as a carbon source. Pyruvate formate lyase (PFL), the founding member of the GRE superfamily, was first identified several decades ago. In recent years, sequencing technology has enabled the annotation of thousands of unique GRE-encoding sequences. Several dozen of the identified GREs have been characterized further, providing insight into the structure, mechanism, and regulation of this multitudinous and diverse enzyme family. Here, we introduce the superfamily, summarize what is known about their activation and catalysis, note conserved structural features, expand on the previously identified GRE classes, highlight GRE-associated bacterial microcompartments, and discuss the future and outlook of the GRE superfamily.
pubs.acs.org
Just a treasure of a scientist... www.annualreviews.org/content/jour...
JoAnne Stubbe's Radical Path: A Story of Passion, Curiosity, and Persistence
Massachusetts Institute of Technology Professor Emerita JoAnne Stubbe was the chair of Mary O'Reilly's thesis committee. Over a decade later, they became neighbors, and then a global pandemi...
annualreviews.org
It's official! ASSOCIATE PROF!!! Huge thanks to all my students, in class and in the lab, for helping make this happen. In particular, my first cohort of graduate students. You all made this job fun through a pandemic, strikes, etc. Not letting off the gas yet and looking forward to what's to come.
Very excited to finally have this out! Non-canonical P450s with a natively encoded axial selenocysteine! Congrats to all, including former student Juan Carlos!! www.nature.com/articles/s41...
Discovery of noncanonical cytochrome P450 enzymes in nature - Nature Chemical Biology
Cytochrome P450s catalyze essential reactions and carry a strictly conserved proximal cysteine ligand. Here, we identify noncanonical P450s that harbor diverse proximal ligands, including serine and s...
nature.com
Planted a tree today in a community restoration project. One fool-proof way to beat back the malaise/fury of the current national situation is to be involved locally. Will be doing more of this as therapy.
Wonderful week in the Greene lab! Ben defended his thesis on rational control of PCET thermodynamics in flavoproteins, Alison walked for her PhD graduation, and several undergraduates graduated to be off to med school, internships, etc. congrats all! 🎉🎉
Voter turnout in Santa Barbara county in this latest primary election was 27%. Shame. First and foremost on the uninspiring and lazy candidates, but close second on my fellow countymen and women…
This was a wonderful, insightful, and sometimes scary interview with Yuval. Highly recommend. open.spotify.com/episode/6mYi...
Yuval Noah Harari on Donald Trump’s Core Delusion
open.spotify.com
Buttigieg with the 7-mo taxpayer funded road trip to Afghanistan in response to road rules ass rocket is chefs kiss.
It is an interesting experience, traversing not having a kid to having one. It really makes it clear that the best adults are those that protect and cultivate children. Not just their own, if they have them, but all children. We all grow up better when raised with support. The shade we never enjoy.
