CHIPS trial (Cold Platelets) published in JAMA jamanetwork.com/journals/jam... Adaptive trial to assess how long platelets can be stored cold while maintaining noninferiority to warm stored platelets (the trial gradually extended the duration as noninferior data came in).

Cold and Room-Temperature Platelets in Cardiac Surgery

This noninferiority randomized clinical trial determines the maximum cold-storage duration and hemostatic efficacy of cold-stored vs room-temperature platelets in patients undergoing transfusion for a...

jamanetwork.com

Reposting because this show is such a balm to the wound of Mondays

Emily Riederer@emilyriederer.bsky.social · 7mo ago

I deeply believe causal thinking is core to good DS regardless if you do analytics, ML, etc A new-to-me resource is the excellent In the Interim podcast on clinical trial design Comes out weekly and takes the sting out of my Monday commute Check it out! www.berryconsultants.com/resources/po...

Great post @apsmunro.bsky.social! Doing more is such a natural reaction. But even 'benign' interventions may likely be harmful when tested properly. I'm yet to know of a trial for sepsis where adding antibiotics has been beneficial (outside of TB where we do it to prevent emergence of resistance).

Alasdair Munro@apsmunro.bsky.social · 4mo ago

My new post looks at two antimicrobials which have been routinely used and even recommended in guidelines despite a lack of RCT evidence In the last few weeks they’ve both been shown to have no benefit, and worse, high probability of harm - killing patients A lesson we keep failing to learn

In college I lived a couple hundred meters from where Mr Rogers was made. My very young cousin heard this and apparently believed for years I lived in Mr Rogers neighborhood.

David Hollingsworth 🏳️‍🌈@daveyh39.bsky.social · 7mo ago

"To love someone is to strive to accept that person exactly the way he or she is, right here and now." - Fred Rogers In loving memory of the beloved and forever impactful Emmy/Grammy-winning television icon, minister, advocate, and pillar of true human decency on his 98th birthday.

JAMA Statistical Editor @rogerjlewis.bsky.social, MD, PhD, and Steve Webb, MBBS, MPH, PhD, discuss the key features of platform trials, including adaptive structures, shared control groups, and domain-based randomization. 🎧 Listen now: ja.ma/3Pk33oU

This workplace has had 0 days since we were told the ICMJE guidelines for authorship are...optional...with respect to our employees, and they may not be included in a paper regardless of their level of involvement.

Why why why why do people cut and paste huge amounts of information between the Protocol, SAP, and assorted other documents. This is essentially expressing a huge preference toward inconsistent documentation and a desire to triple the workload of anyone working on any change to any document.

Utilities. If you aren’t using good ones explicitly, you are likely using bad ones implicitly.

Adam L@adam-lg.bsky.social · last yr.

47. People really don't know what to do with ordinal variables, so they either treat them as continuous or dichotomize them

I can see my kids adding "but we are still collecting data to increase power".....

Charnel Pleasures@charnel-pleasures.bsky.social · last yr.

After like a decade and a half of free-riding on @zachweinersmith.bsky.social’s public goods, I finally decided to engage in a Coasean bargain to compensate for my consumption of his externalities. @smbccomics.bsky.social #SMBC #Economics #stats

I think this issue is one of the most appealing aspects of Bayes. With Bayes the posterior distribution is the basis for inference, and it is invariant to the design.

Triad sou.@triadsou.bsky.social · last yr.

Confidence Intervals for Adaptive Trial Designs II: Case Study and Practical Guidance. David S. Robertson, Thomas Burnett, Babak Choodari-Oskooei, Munya Dimairo, Michael Grayling, Philip Pallmann, Thomas Jaki. Statistics in Medicine. onlinelibrary.wiley.com/doi/10.1002/...

And you thought reviewer 2 was rough…

Derek Beres@derekberes.bsky.social · last yr.

A large-scale, government-funded study tracking 1.2M children over two decades found something Kennedy doesn't like, so he wants it retracted. www.reuters.com/business/hea...

📢 Apply now for the JAMA Network Peer Review Academy! This 9-month remote program connects early-career researchers with JAMA Network editors for hands-on peer review training. https://ja.ma/3TlIeIO

The Staphylococcus aureus Network Adaptive Platform (SNAP) trial has been nominated for a Patient healthcare communication award! Public voting is now open 👉 ccrew.accesscr.com.au/cpir-2025/pu... Find out more about SNAP 🔗 www.snaptrial.com.au Give us a vote!! @thedohertyinst.bsky.social

Saw the animal farm argument of statistical inference presented this morning. “When Bayes and frequentist are equal use frequentist” because apparently some are more equal than others.

I continue to find the endowment argument bizarre. Research grants are paying money for a service. We don’t ask a defense contractor to spend down all their bank accounts before we pay for a plane. Why before we pay for research?

Ellie Wolfe@elliew0lfe.bsky.social · last yr.

BREAKING: Amid more federal funding and research cuts, Johns Hopkins University is pausing pay increases, freezing staff hiring and reducing capital projects by up to 20%. The university is on track to lose nearly $1 billion in funding — so far. Read: www.thebaltimorebanner.com/education/hi...

For all clinical trialists who don’t believe in bringing in historical information or hierarchical borrowing across subgroups….a question…Aaron Judge is currently batting about 0.400. Do you take 0.400 as the best estimate of his 2025 average, or something lower? 🧵

3968

Seth Trueger@mdaware.org · last yr.

Implement a 100% tariff and ruin a movie The F16 of the Furious

The most important thing in any job is that your boss and administration has your back. If you're looking for an academic job in the US...start with this list.

James Fallows@jfallows.bsky.social · last yr.

When this statement from university prez came out ten days ago, it has ~ 180 signatures. Today it is nearing 600. www.aacu.org/newsroom/a-c... A hard choice for many of these institutions. Especially earliest signers, who had no idea how much company they'd have. But people keep standing up.

Stay tuned for the first @cmicomms.bsky.social & #Breakpoints collaboration episode on Sun, May 4th 6PM US EST/Mon May 5th 12 AM CET. Hosts Angela Huttner & Erin McCreary interview SNAP trial investigators, Steven Tong &Joshua Davis, on PSSA and MSSA domain results shared at 2025 ESCMID Global.

Please apply if your interested in running a new adaptive platform trial for invasive Streptococcal infections. Will work closely with the #SNAP_trial team. @thedohertyinst.bsky.social Applications close May 20 2025. jobs.unimelb.edu.au/en/job/92003...

Details : Project Manager : The University of Melbourne

Careers at The University of Melbourne

jobs.unimelb.edu.au

Response adaptive randomization adjusts allocation probabilities over the course of a trial, based on accumulating data. RAR increases allocation to arms performing well, and decreases allocation to arms performing poorly. In multiple arm trials, this has advantages over fixed randomization.

Antibiotic Steward 🅱️C🆔🅿️🌟@absteward.bsky.social · 2y ago

Not gonna lie, I’m still wrapping my head around RAR (Response-Adaptive Randomization). Anyone have a simple breakdown? #idsky

RA Fisher on factorial trials. An ongoing missed opportunity in medical research. "No aphorism is more frequently repeated in connection with field trials, than that we must ask Nature few questions, or, ideally, one question at a time. The writer is convinced this view is wholly mistaken... (1/2)

One of my interests is the love/hate relationship statisticians have with data. Want to approve a drug or treat a patient today? Look at the available evidence!! Want to design an experiment...many statisticians answer..IGNORE the available evidence!! Why? www.berryconsultants.com/resource/8-e...

8: External Data in Clinical Trials | Podcast Episode

In this episode of

berryconsultants.com

My advice to all my PhD students on defense day….”wait for your committee members to start arguing amongst themselves, and then just watch the show”

Trish Greenhalgh@trishgreenhalgh.bsky.social · 2y ago

PhD student sends me this. Ouch.

I’d be inclined to think hospitalizations are more accurate than case counts. People are more likely to take a really sick kid to a doctor and get counted while mild infections go unreported. Of course hospitalizations are fewer and more variable. Also….

Megan Ranney MD MPH@meganranney.bsky.social · 2y ago

Important article - glad to be quoted along with @craigspencer.bsky.social abcnews.go.com/Health/rfk-j...

Interesting experimental idea. Curious if the result indicates a prior distribution on “coins are fair” as much as a statement on likelihoods. Would have been interesting to also investigate a “novel” source of randomness.

Nick Byrd, Ph.D.@byrdnick.com · 2y ago

"Is p < 0.05 a reasonable threshold?" Over 500 students and survey workers flipped a coin that never landed on tails. They recorded how many flips it took to realize the coin was unfair. On average, it corresponded to p = 0.005. doi.org/10.4473/TPM2... #stats #philSci #xPhi

As best I can tell they can grab me or my kids off the street, move us around fast enough we don’t know where to file a claim, intimidate our potential lawyers to not represent us, and then once we are outside the US claim “oops nothing anyone can do”. How is anyone ok with this?

I believe virtually all trial results should be public. Sponsors pay for trials but participants give precious resources. Society benefits from full transparency. Deidentified of course, likely with delays, but if you experimented on a human you owe humanity the results.

Marion Campbell@marionkcampbell.bsky.social · 2y ago

Clinical trials are nothing without their participants and it is key that the results of trials are shared with them. But this is still not routinely done. 1/7 #MethodologyMonday #115

I wouldn’t guess exactly how but wouldn’t be surprised if reporting of cases is very different in the two locales.

Paul DeCampo@pauldecampo.bsky.social · 2y ago

Canadians should note that there are more measles cases *655* in Ontario alone than in this USA outbreak. www.cbc.ca/news/health/...