Roger J. Lewis, MD, PhD
@rogerjlewis.bsky.social
Emergency physician and statistician; Bayesian adaptive and platform trial clinical trial design and implementation; Senior Statistical Editor at @jama.com.
📌 How can clinicians and researchers stay up to date on the most clinically relevant trials? Follow JAMA+ Trials to get curated access to the best of the JAMA Network’s trial research, commentaries, and educational resources: jamanetwork.com/channels/tri...
JAMA+ Trials Research, Education and Commentary from JAMA Network
Find high-quality clinical trial research with JAMA+ Trials, offering curated studies, multimedia insights, and advanced search across the JAMA Network.
jamanetwork.com
Fauci's Diary, the Origins of COVID, and Bad Headlines open.substack.com/pub/ninalewi...
Fauci's Diary, the Origins of COVID, and Bad Headlines
The diary shows a scientist investigating and ruling out a remote possibility. Not one headline said so.
open.substack.com
My thoughts about Tony Fauci. He was very demanding to work for because he was involved in so many things, but his staff deeply respected him and relished working with him, even with some challenges. They appreciated his demands for high standards in everything that they did. 1/2
Jenna Norton@jenna-m-norton.bsky.social · last wk.Not every NIH institute director is uniformly loved by their staff. But I’ve never heard criticism of Tony Fauci. (side note: @jeremymberg.bsky.social is another former IC director who seems universally loved by his staff.) Some comments I’ve heard from colleagues today: “He’s an American hero.”
A statistical model for lung function trajectory and mortality in patients with fibrotic interstitial lung disease A new model for evaluating treatments in ILD holds promise for improving the accuracy and efficiency of clinical trials doi.org/10.1093/ajrc... @rogerjlewis.bsky.social
A summary of recent events where foreign leaders stopped rolling over when Trump publicly humiliates them. They are finding their spines. Too bad politicians in this country can't seem to find theirs. Yet.
The World Is Done Playing Nice With Trump
Foreign leaders who try to appease him are learning that, to Trump, appeasement smells like prey. They are done being prey.
open.substack.com
Although best practices are established for managing 𝘚𝘵𝘢𝘱𝘩𝘺𝘭𝘰𝘤𝘰𝘤𝘤𝘶𝘴 𝘢𝘶𝘳𝘦𝘶𝘴 bacteremia, the preferred antibiotic for methicillin-susceptible 𝘚. 𝘢𝘶𝘳𝘦𝘶𝘴 bacteremia is uncertain. Research findings from the SNAP trial are summarized in a new Quick Take video. https://nej.md/4uBjkVL
TLDR: Makary, Hoeg, and Prasad were incompetent political hacks and it will take years to undo their damage.
Making the FDA Great Again
This JAMA Forum discusses staffing and policy changes at the US Food and Drug Administration (FDA) over the past year.
jamanetwork.com
My sister is an expert in computer security and I'd like to encourage folks to explore her (free) substack posts exploring larger patterns in current events--helping us to see the forest even as we're being bombarded every day with leaves, branches, and sometimes trees. ninalewis174247.substack.com
The Bigger Picture | Nina Lewis | Substack
I look for the big picture - patterns in the current and recent news events, patterns that might suggest future directions or provide insight into why things are the way they are. Click to read The Bi...
ninalewis174247.substack.com
Good plain language summary of a very bad policy proposal. www.nytimes.com/2026/06/09/o...
Opinion | Trump’s Assaults on Scientific Research Just Got Worse
nytimes.com
The push to cut funding from the National Academies of Science will involve illegally impounding funds on the claim that fringe Republican lawmakers understand what constitutes the “gold standard” for science better than the best scientists in America. www.aip.org/fyi/republic...
Republican Lawmakers Suggest Cutting Off Funding for National Academies
A letter from 11 Republican representatives has caught the White House’s attention.
aip.org
In children with septic shock, no significant difference was seen in the incidence of death, new renal-replacement therapy, or persistent kidney dysfunction with balanced fluid as compared with 0.9% saline for fluid resuscitation. Full PRoMPT BOLUS trial results: nej.md/4tvygVy #PAS2026
US state-level policy responses to shifting federal guidance varied widely in 2025, with most states acting to preserve #COVID19 vaccination access through standing orders, insurance coverage, or clinician authority. ja.ma/4ckW8Fh
The most impactful clinical ILD study in ages! 🌟 True multidisciplinary collaboration driving progress 🫁 @rogerjlewis.bsky.social @ipfdoc.bsky.social A Statistical Model for Lung Function Trajectory and Mortality in Patients with Fibrotic ILD academic.oup.com/ajrccm/advan... #OpenAccess
This is the face of a lunar scientist who has just been told that the #Artemis II crew saw SEVERAL impact flashes (the flashes when meteors hit the lunar surface) in real time 😃 🌓💥
Thomas Fuchs@thomasfuchs.at · 4mo agoscience lady is excited
JAMA Statistical Editor @rogerjlewis.bsky.social MD, PhD, and Natalie Dean, PhD, discuss the test-negative study design, highlighting its role in analyzing effectiveness and minimizing bias in observational studies. 🎧 Listen now: ja.ma/4tl3MF9
I stopped and stared at the price per ounce numbers for a few minutes trying to reproduce Kroger's / Ralph's math, especially since they are misleading in way that would make you buy a larger package that was actually more expensive per ounce.
JAMA Statistical Editor @rogerjlewis.bsky.social, MD, PhD, and Steve Webb, MBBS, MPH, PhD, discuss the key features of platform trials, including adaptive structures, shared control groups, and domain-based randomization. 🎧 Listen now: ja.ma/3Pk33oU
I wonder what decision process or discussion initially led to this course of action, let alone the decision to perpetuate it. It's difficult for me to picture it.
Swapnil Hiremath 🍁🇨🇦@hswapnil.medsky.social · 5mo agoThis story is nuts The journal ‘Pediatrics and Child health’ has been published an article type, for case reports, that are made up and fictional without having any clear notice 😱 retractionwatch.com/2026/03/03/c...
The updated PECARN rule reliably identified low-risk febrile infants, with no missed cases of bacterial meningitis, potentially reducing routine lumbar punctures. bit.ly/3Zkwf1a
Among patients with acute ischemic #stroke due to non–large vessel occlusion, #tenecteplase administered 4.5 to 24 hours after symptom onset increased excellent outcomes but raised the risk of intracranial #hemorrhage. #ISC26 📽️ Watch the video & read the full study: bit.ly/4kgH1yQ
📊 JAMA Guide to Statistics and Methods: The win ratio is a statistical method for hierarchical composite outcomes, offering a patient-centered summary of treatment effects by prioritizing more important clinical events in clinical trials. ja.ma/4qIidSJ
In this podcast, @rogerjlewis.bsky.social, MD, PhD, Senior Statistical Editor for JAMA, speaks with Kendra Sims, PhD, postdoctoral associate at @busph.bsky.social, about how tipping point analysis can help assess the robustness of study findings. Listen now: ja.ma/49fpFi5
Some beautiful keepsakes nurses made for a dying patient's family at Harbor-UCLA.
“I did not resign to make a symbolic point. I resigned because staying silent would have made me complicit. I spoke up because the stakes for children, communities, and our preparedness are too high.” time.com/7338714/dr-d...
I Left the CDC 100 Days Ago. My Worst Fears About the Agency Are Coming True
"Things have not improved," writes Dr. Debra Houry. "They have worsened. And Congress has still failed to act."
time.com
Here, here. "Congress must now also exercise its oversight responsibilities to ensure repairs to FDAs current and future capabilities, infrastructure, human resources, and reputation begin as soon as possible." Big deal coming from investors/companies. www.nopatientleftbehind.org/evidence-bas...
Supporting the Call for Evidence-Based Policy and Public Health Security — No Patient Left Behind
nopatientleftbehind.org
