Excited to share my lab's first paper -- a perspective piece in @natcellbio.nature.com exploring how the mRNA lifecycle is affected by cellular aging! 🔬🧪https://www.nature.com/articles/s41556-026-01946-4

RNA imbalance as a hallmark of cellular ageing - Nature Cell Biology

This Perspective highlights the failures of an ageing cell in properly maintaining mRNA health at the various steps of the mRNA life cycle that result in vulnerability to disease, pointing to RNA imba...

nature.com

I am excited to share the second half of my postdoctoral work in the Yeo lab at UCSD! We found that neuronal aging leads to the accumulation of mitochondrial double-stranded RNA, which triggers the chronic stress response. 1/ www.biorxiv.org/content/10.1...

I am excited to share that I will be starting my lab @uarizona.bsky.social this summer! Our research will focus on how aging impacts neuronal resilience and RNA biology; we will be part of the Coit Center for Longevity & Neurotherapeutics. sites.arizona.edu/rhine-lab/

Neuronal aging leads to widespread dysregulation of RNA biology, including mislocalization of splicing proteins like TDP-43, chronic cellular stress, and reduced resiliency @kevinrhine.bsky.social www.nature.com/articles/s41...

Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress - Nature Neuroscience

Rhine et al. find that neuronal aging leads to widespread dysregulation of RNA biology, including mislocalization of splicing proteins like TDP-43, chronic cellular stress and reduced resiliency.

nature.com

The Research Briefing accompanying our paper is now out too! www.nature.com/articles/s41...

RNA dysregulation impairs stress resilience in aged neurons - Nature Neuroscience

Aging is a primary risk factor for neurodegenerative diseases. This study shows that key RNA pathways are disrupted in old neurons, including splicing and the stress response. Because of these changes...

nature.com

Kevin Rhine@kevinrhine.bsky.social · last yr.

Excited to share my postdoctoral research on how neuronal #aging contributes to RNA dysfunction is now online at Nature Neuroscience! Here we find that aged neurons suffer from chronic cellular stress that compromises resiliency to new stressors🧪 www.nature.com/articles/s41...

Excited to share my postdoctoral research on how neuronal #aging contributes to RNA dysfunction is now online at Nature Neuroscience! Here we find that aged neurons suffer from chronic cellular stress that compromises resiliency to new stressors🧪 www.nature.com/articles/s41...

Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress - Nature Neuroscience

Rhine et al. find that neuronal aging leads to widespread dysregulation of RNA biology, including mislocalization of splicing proteins like TDP-43, chronic cellular stress and reduced resiliency.

nature.com

Honored to be funded by the @alsassociation.bsky.social and their Seed Grants Program! Aging-linked changes in TDP-43 biology don't stand a chance 😎 www.als.org/blog/catalyz...

Catalyzing the Future: New Grants Will Accelerate the Transformation of Innovative Ideas into Clinical Realities

Catalyzing the Future: New Grants Will Accelerate the Transformation of Innovative Ideas into Clinical Realities

als.org

Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.

Excited to share the preprint of the last portion of my grad work with co-first-author Gemechu Mekonnen and my adviser Sua Myong! We show that the RNA helicase DDX6 can tune the nucleation and fluidity of FUS condensates, including ALS-linked variants. Read more here: papers.ssrn.com/sol3/papers....