Extremely excited about the results of @adaptyv.bio RBX1 binder design competition! 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕2 performed very well, with 3 out of 7 designs binding to the disordered tail. Overall, only 9 binders worked out of 322 tested, 2.8% hit rate! Proud of the BC2 team ♥️ (Erik, Liza, Leo)

We’ve got a binder in the GEM-Adaptyv RBX1 Binder Design Challenge, and it ranked #8 out of 322 tested proteins with a Kd of 570 nM. Congratulations to all the winners, and thanks to the organizers.

Fold-Conditioned De Novo Binder Design via AlphaFold2-Multimer Hallucination. [new] FoldCraft: uses AlphaFold2-Multimer with contact map loss to hallucinate novel binders with user-defined folds, improving nanobody design.

Fold-Conditioned De Novo Binder Design via AlphaFold2-Multimer Hallucination. https://www.biorxiv.org/content/10.1101/2025.07.02.662497v1

🧬 "MSA clustering enhances AF-Multimer's ability to predict conformational landscapes of protein-protein interactions" explores how MSA sampling improves #AlphaFold's performance in predicting binding mechanisms for proteins with multiple states. Learn more: doi.org/10.1093/bioa... #ProteinFolding