so excited to share that our preprint characterizing the dorsal anterior cingulate cortex in post-mortem human brain from @lieberinstitute.bsky.social is out! we integrated matched SRT and snRNA-seq data to investigate agranularity and von Economo neurons

my work with @stephaniehicks.bsky.social and @boyiguo.bsky.social has been published in Biostatistics! tldr: the mean-variance bias exists in SRT data & impacts SVG detection. we propose #spoon, available on @bioconductor.bsky.social, to address this! pmc.ncbi.nlm.nih.gov/articles/PMC... 🤩

Kinnary Shah is a fourth-year PhD candidate and co-president of the Biostats Student Org. Learn more about Kinnary and two of her ongoing research projects, one with the @lieberinstitute.bsky.social, and one with @stephaniehicks.bsky.social, on our website: publichealth.jhu.edu/departments/...

despite the rough start, I *think*🤞 I'm on my way, and I am excited and honored for the opportunity to present work led by @kinnaryshah.bsky.social identifying molecular rationale behind evolutionary specializations in the cingulate versus the prefrontal cortex of human 🧠

i had the great opportunity to present some of our work integrating dACC SRT and snRNA-seq data from neurotypical donors at #STATGEN2025 today! keep your eyes peeled for this project - coming out soon 🧠🧬

thank you @stephaniehicks.bsky.social and @boyiguo.bsky.social for your amazing mentorship on this project! so excited that this is finally out

Stephanie Hicks@stephaniehicks.bsky.social · 2y ago

Fantastic poster from @kinnaryshah.bsky.social tonight at #biodata24! She developed the spoon package to correct for the mean variance relationship in #spatial transcriptomics data #ProudPI #stats 🖥️🧬🧪🧠📈 Preprint: www.biorxiv.org/content/10.1... Software: www.bioconductor.org/packages/spoon