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Keri Martinowich

@martinowk.bsky.social

Chief Scientific Officer, Lieber Institute and Professor, Johns Hopkins School of Medicine studying molecular regulation across species in circuits impacted in complex brain disorders. Native plants/flowers/wetland habitats. Own opinions.

1373 Posts6132 Follower1642 Folgt
Heidi Jacobs@heidijacobslab.bsky.social · 3h ago

Excited to share our latest work: Inspired by animal work, we demonstrate that astrocyte reactivity amplifies the effect of lower #locuscoeruleus function on higher ptau, and these processes together are associated with steeper cognitive decline. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Astrocyte reactivity modifies the effects of locus coeruleus norepinephrine‐related dysfunction on tau and its impact on cognition

INTRODUCTION Animal models demonstrated that pharmacologically-induced lesioning of the locus coeruleus (LC), the brain's primary source of norepinephrine, triggered astrocyte reactivity, exacerbati...

alz-journals.onlinelibrary.wiley.com

dennis hernaus@dhernaus.bsky.social · last wk.

Why do people stop pursuing goals they care about❓ Motivational deficits are among the most disabling symptoms, yet current treatments often have only modest effects. In @lillyt.bsky.social new paper, she asks if we're missing an important piece of the puzzle 🧠 #neuroscience #cogpsyc #psychscisky

Arousal shapes motivation: an integrative framework for understanding motivational deficits - Translational Psychiatry

Translational Psychiatry - Arousal shapes motivation: an integrative framework for understanding motivational deficits

nature.com

Keri Martinowich@martinowk.bsky.social · 6h ago

Going through my very first F31 summary statement this morning to pull out some choice comments on my scientific potential to post in a Slack discussion w/ a student going through their statement... which is facilitating some morning musings on how spite can be one hell of a drug in this business.

Danielle Beckman@daniellebeckman.bsky.social · 8h ago

Your imaging pipeline doesn't end after the microscope! Join us in Munich for a hands-on 2-day course covering deep learning, atlas registration, VR-assisted segmentation, and more. A big thanks to @klaus-tschira-stiftung.de for supporting this initiative!

Philip Ruthig@philipruthig.bsky.social · yesterday

Got your own (mouse brain-) 3D data from clearing and light sheet imaging, but no idea how to tackle the analysis? We have just the solution for you in Munich: A two-day course on deep learning and VR-assisted segmentation, atlas registration, and so on! Take the course at @erturklab.bsky.social

Jennifer Bussell PhD@jenbussell.bsky.social · 6d ago

How does the brain represent the value of knowledge? In our paper--out now at Nature Neuroscience--we identify a representation of intrinsic information value within neural population structures in the orbitofrontal cortex in mice. www.nature.com/articles/s41593-026-02377-y #neuroskyence 🧠🧪 (1/8)

Representations of the intrinsic value of information in mouse orbitofrontal cortex - Nature Neuroscience

Mice are motivated to seek information of no extrinsic value. Recording neural activity in orbitofrontal cortex reveals a representation of the value of information that is distinct from the value of ...

nature.com

Talia Lerner@talialerner.bsky.social · 2d ago

One of the coolest parts, though it’s still preliminary, is that we used biophysical modeling to identify a likely channel behind the CeA hyperexcitability (M-current/KCNQ). This gives us a molecular target to chase.

Talia Lerner@talialerner.bsky.social · 2d ago

We found that central amygdala (CeA) neurons projecting to the midbrain become hyperexcitable after adolescent stress, which switches ON a new, reward-responsive pattern of dopamine release in the tail of striatum (TS).

Talia Lerner@talialerner.bsky.social · 2d ago

🚨Happy to share a new preprint from Lerner Lab led by graduate student @nadelneurosci.bsky.social! 🚨 “Adolescent stress recruits a latent amygdala-dopamine circuit to drive punishment-resistant reward-seeking” This has been a wholly impressive effort by Jacob; summary below 👇 #neuroskyence🧪

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2d ago

Adolescent stress recruits a latent amygdala-dopamine circuit to drive punishment-resistant reward-seeking https://www.biorxiv.org/content/10.64898/2026.07.29.741478v1

Ben Saunders@bensaunders.bsky.social · 2d ago

The final version of our amygdala dopamine paper is out! BLA dopamine dynamically tracks emotional salience and not value or reward prediction error. Congrats to Dr. Megan Brickner!! www.nature.com/articles/s41...

Basolateral amygdala dopamine transmits emotional salience - Nature Communications

The basolateral amygdala dopamine system has received little attention. Here, authors show that BLA dopamine plays a unique role in learning, by encoding the emotional salience of sensory cues to supp...

nature.com

Stephanie L. Grella, PhD@sgrella.bsky.social · 6d ago

I am honoured to share that I have been selected as a recipient of the 2026 BBRF Young Investigator Grant! 🎉 I am incredibly grateful to the Brain & Behavior Research Foundation for this support and to my mentors, collaborators, colleagues, and trainees for their encouragement and support.

Robin Magnard@robinmagnard.bsky.social · 6d ago

🧠🧬 What are the effects of intravenous fentanyl self-administration on the habenula and amygdala transcriptomes? In our new Addiction Biology paper, we addressed this question using a chronic long-access model in rats! Here are some highlights 🧵👇 Paper 👉 dx.doi.org/10.1111/adb....

Transcriptional Response to Chronic Long‐Access Fentanyl Self‐Administration in Rat Habenula and Amygdala

Chronic intravenous long-access fentanyl self-administration in rats produced transcriptional remodeling in the habenula and amygdala. Bulk RNA-sequencing identified 453 habenula and 3,041 amygdala d...

dx.doi.org