KLAB - finding a cure for GI dysmotility at #HarvardStrong
@klab.bsky.social
Neurobiology Lab studying development, maintenance, and aging of the Enteric Nervous System. Home of 'enfant terrible' of enteric neurobiology https://www.enteric-neuron.com
@jasonrkelly.bsky.social interesting post in @bostonglobe.com but I wonder how you are squaring up promoting biotech jobs in Boston with your push for automated labs and AI, which IMHO will reduce the employment footprint. The hand-wavy argument that automation will increase employment wont cut it
Massachusetts built biotech; China is catching up - The Boston Globe
The state can’t afford to lose the state’s signature industry.
bostonglobe.com
Someone should ask Marcia McNutt where the industry jobs are that we should be training Biological Sciences postdocs and graduate students for? After all, she is all in on the ABUNDANCE agenda and she would know Right?
Seth Meyers: Right?!
ALT: Seth Meyers: Right?!
static.klipy.com
The National Academy of Sciences (NAS) mirror most scientific societies: lacking courage, clarity, and leadership. Like other societies, NAS has drifted from its mandate of defending science with vision and integrity. The difference is that not every society has sold out. NAS has.
What Roy Blunt is saying is that this is not the worst times, cause the worst is yet to come @nationalacademies.org
How is it surprising that the Head of @nationalacademies.org is an out of touch administrator? What is shocking is that folks thought these societies work for promoting science rather than protecting their turf
Cynthia Erivo Shocked
ALT: Cynthia Erivo Shocked
static.klipy.com
While it is a bit alarming when the water rises above your waist, it is far more alarming when it rises above your nose. It is a travesty that despite this, someone is still refusing to turn off the tap. It is beyond tragic that we cannot discriminate between a 3 alarm and a 5 alarm fire
Drug Monkey@drugmonkey.bsky.social · 2mo agoIt is not inherently more tragic when a NIH grant that got a 2%ile versus an 8%ile or 15%ile goes unfunded.
We identified novel #autoantibody signatures that discriminate between clinically defined subtypes in #Scleroderma (SSc) & While doing that identified a new human protein family called TiSSc (Targeted in SSc) that is targeted by autoantibodies in one distinct patient subtype. Read more here:
biorxiv.org
We are at a point where Generating hypeby misrepresenting stuff in papers = great Generating hype by misrepresenting stuff in talks = great Using LLM to write papers = sin The anger is not towards falsehoods, but against use of LLMs to do so No wonder then...
We Are So Cooked
ALT: We Are So Cooked
static.klipy.com
@nature.com and Colossal with their hype generating machine
Grinch's Sly Smile: Trust Me!
ALT: Grinch's Sly Smile: Trust Me!
static.klipy.com
Reading the comments of this news article is *chefs kiss*
‘A loss for the nation’: MIT president says research has fallen 10 percent, and grad student enrollment is down - The Boston Globe
Total research funding has dropped 10 percent from a year ago while the school expects to enroll 500 fewer graduate students in the next academic year.
bostonglobe.com
Like it or hate it, but the Question remains. At what point of time does @openevidence.bsky.social or a similar LLM replace the Primary Care #Physician? Will your primary care in the near future be managed by an #LLM and not a #PCP?
Most U.S. doctors are quietly using this AI tool. Few patients know about it.
OpenEvidence, an AI-powered medical search tool, has become a fast friend to America’s doctors and is now used by nearly two-thirds of physicians.
nbcnews.com
Excited to share new work from our lab that details a novel mechanism by which #Enteric #Neurons put a brake on proliferation of #Colon #Cancer cells
bioRxiv Cancer Bio@biorxiv-cancer.bsky.social · 3mo agoEnteric neurons modulate colorectal cancer cell cycle through a PCSK1 - Methionine-Enkephalin Axis https://www.biorxiv.org/content/10.64898/2026.05.03.722515v1
Stress doesn’t just affect your head, it also messes with your gut. While we have all dealt with it, we dont have a cure for it. Cause? Lack of basic mechanistic science. Our paper published today identifies a mechanism by whichstress slows gut down, and how to cure it www.jbc.org/article/S002...
Stress-induced glucocorticoid signaling impairs enteric neurotrophin BDNF–TrkB pathway and drives gastrointestinal dysmotility
Stress is a key contributor to gastrointestinal (GI) dysmotility, particularly in patients with disorders of gut-brain interactions (DGBI). Since GI motility is governed by the enteric nervous system ...
jbc.org
Wonderful work from @honghaocao.bsky.social and @sixianyou.bsky.social on crafting a new method to study the enteric nervous system and associated cells. This was a really interesting and fun collaboration between our labs! www.nature.com/articles/s41...
Self-localized ultrafast pencil beam for volumetric multiphoton imaging - Nature Methods
A self-localized, ultrafast pencil beam can be readily introduced into multiphoton microscopes and applied for near-diffraction-limited, high-throughput volumetric imaging in intact tissues and in vit...
nature.com
Watch intently to better your Significance and Innovation section for your NIH grants youtu.be/5ptUMe9eqYE?...
Ministry of Silly Walks | Monty Python (Official Sketch)
YouTube video by Monty Python
youtu.be
How about first publishing papers that your editors don't pre-judge on the 'impact' of the study
Nature@nature.com · 3mo agoFailure is part and parcel of research, but discussing it sometimes seems to be taboo in science. It doesn’t need to be go.nature.com/3QHXZvk
"What the fuck do you mean by data available on request?"
If you have ever wondered why that one particular faculty in your field/dept/school behaves the way he/she does...
eLife@elife.bsky.social · 4mo agoThe self-interest of adolescents overrules cooperation in social dilemmas
Ever wondered why 90% of #Rett Syndrome (RTT) patients suffer from severe #GI issues like chronic #constipation? A new study from our lab digs into this using an Mecp2 KO mouse model. (1/n)
bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 4mo agoLoss of enteric BDNF TrkB signaling and VIPergic dysfunction underlie gastrointestinal dysmotility in a Mecp2-null mouse model of Rett syndrome https://www.biorxiv.org/content/10.64898/2026.04.12.718037v1