Research | Lekkos et al. show that a metabolic switch towards oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in fish. doi.org/10.1038/s441... rdcu.be/eJ3sB

Oxidative phosphorylation is required for cardiomyocyte re-differentiation and long-term fish heart regeneration - Nature Cardiovascular Research

Lekkos et al. show that a metabolic switch toward oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in fish.

doi.org

Last week's spooky creations, courtesy of IDRM's Mommersteeg Group, were carved just in time for Halloween! @tillymommersteeg.bsky.social

New research led by @klekkos.bsky.social and @tillymommersteeg.bsky.social at the IDRM and DPAG has uncovered an essential role for oxidative metabolism in heart regeneration. Read the full paper here: www.nature.com/articles/s44... Read the overview of the study: tinyurl.com/2syythet

Do zebrafish regenerate their hearts equally? In our new paper at the @tillymommersteeg.bsky.social lab we uncovered variations in the regenerative response of 7 wt zebrafish strains leading us to identify a critical role of oxidative phosphorylation in long-term heart regeneration. rdcu.be/eI1v5

Oxidative phosphorylation is required for cardiomyocyte re-differentiation and long-term fish heart regeneration

Nature Cardiovascular Research - Lekkos et al. show that a metabolic switch toward oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in...

rdcu.be

🎉 Congratulations to Konstantinos Lekkos, a 2nd year DPhil student in the Mathilda Mommersteeg Group. Kostas won first prize at this year’s Oxford MRC-DTP Symposium with his talk on a novel discovery in zebrafish metabolism and heart regeneration. @oxforddpag.bsky.social

👋Meet Konstantinos Lekkos, a DPhil Student in the Mommersteeg group, and our most recent featured member. Kostas' research focuses on the role of oxidative metabolism in zebrafish heart regeneration. Find out more about his research: www.linkedin.com/feed/update/... @oxforddpag.bsky.social

Thank you Prof Noble for giving an astonishing lecture yesterday @oxforddpag.bsky.social! We hope you enjoyed this precious opportunity to discuss with Prof Noble. Next we will have Dr. Xin Zhou on June 17th at 4PM. Stay tuned! Photos taken by Dr Sung Hee Kim, voices of Oxford.

Our first seminar of the term will be delivered by Prof Denis Noble on "The pacemaker channels of the heart: from reductionism to systems biology" this week, on Wednesday the 4th of June at 4pm at the Sherrington Library. As always, a drinks reception will follow for discussion.

Excited to share our preprint! We show that sustained macrophage and B cell responses are essential for heart regeneration in Mexican cavefish, helping uncover why surface fish heal but cavefish scar 🫀🐟. Check out the full story: www.biorxiv.org/content/10.1...

Absence of a prolonged macrophage and B cell response inhibits heart regeneration in the Mexican cavefish

A balanced immune response after cardiac injury is crucial to successful heart regeneration, but knowledge of what distinguishes a regenerative from a scarring response is still limited. The Mexican c...

biorxiv.org

Additionally, we aim to connect students with an interest in the heart sciences through social events. We also organise outreach activities in order to promote awareness for the cardiac sciences in the wider community.

The Heart Rhythm Club is a student-run society providing a platform for students to explore the various aspects of cardiovascular sciences through seminars and discussions with world-leading scientists.

Paper alert! Congrats to Lara, @cmdooley.bsky.social , @douglasadamoski.bsky.social and Thomas Juan for their great work on identifying the first example of Transcriptional Adaption in humans!🎉

@cmdooley.bsky.social · 2y ago

1/? 🧬 New Breakthrough in Duchenne Muscular Dystrophy (DMD)! Our new paper in @Nature reveals how utrophin—a dystrophin “backup”—is upregulated in DMD. The key? Transcriptional adaptation (TA), triggered by mutant mRNA decay, not protein loss. [🔗 Link: www.nature.com/articles/s41...