Ksenia Matlawska-Wasowska @kseniam.bsky.social and team show T-cell leukemia exploits an inflammatory pathway to invade the brain's protective layers: doi.org/10.1172/JCI1... The image features GFP⁺ T-ALL leukemic infiltrates within whole-mount murine meningeal tissue.

Disrupted QKI regulation reshapes RNA splicing programs in T-ALL. This team effort is dedicated to the memory of Pieter, whose scientific curiosity continues to inspire us. haematologica.org/article/view...

Always a pleasure collaborating with the Jones Lab. Awesome science and even better people!

Nick Jones@nickjonesimmuno.bsky.social · 10mo ago

Really pleased to share the labs first publication in paediatric T-cell leukaemia. We find that the type 2 diabetes drug canagliflozin possesses anti-leukaemic effects that can be enhanced via dietary restriction of serine. www.sciencedirect.com/science/arti...

Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts. www.nature.com/articles/s41...

Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Nature Communications

α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors repo...

nature.com

Our fresh and still-steaming Journal of Clinical Investigation preprint is out! 🚀 We explore how T-cell acute lymphoblastic leukemia (T-ALL) exploits inflammatory CXCR3–CXCL10 signaling within the meninges to drive CNS infiltration. www.jci.org/articles/vie...

Really thrilled to have been involved in this project. It’s an absolute mammoth of a paper looking at the way T-cell leukaemia exploits inflammation to colonise the meninges. Congratulations to Nitesh and @kseniam.bsky.social 🍸 Please give it a read! www.jci.org/articles/vie...

Really pleased to share the labs first publication in paediatric T-cell leukaemia. We find that the type 2 diabetes drug canagliflozin possesses anti-leukaemic effects that can be enhanced via dietary restriction of serine. www.sciencedirect.com/science/arti...

Canagliflozin synergises with serine restriction mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia

T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…

sciencedirect.com

The starter pack that all leukemia people were waiting for! This is just a very basic pack, if you want to be included, leave a comment below! go.bsky.app/EY3k2bE

So excited to share our work developing a new class of modular synthetic GPCRs, out today @Nature! Check it out nature.com/articles/s41...

Synthetic GPCRs for programmable sensing and control of cell behaviour - Nature

Modular synthetic G-protein-coupled receptors with nanobody-based ligand-recognition domains can be designed and used to programme transgene expression, real-time fluorescence or endogenous G-protein ...

nature.com

Alice Ting@aliceyting.bsky.social · 2y ago

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

🚨 Save the Date!🚨 ISEH is heading to Kumamoto, Japan for #ISEH2025. Check out our confirmed speakers so far and mark your calendars for a great program you won't want to miss ➡️ iseh.org/iseh2025