Rapid glycolytic metabolism underpins mucosal-associated invariant T cell functional responses to innate cytokines

Abstract. Mucosal-associated invariant T (MAIT) cells express a semi-invariant T cell receptor (TCR) that recognizes bacterial-derived antigens presented o

academic.oup.com

Postdoctoral Associate

Rutgers, The State University of New Jersey is seeking a Postdoctoral Associate within Cancer Pharmacology at the Rutgers Cancer Institute.The primary purpose of the Postdoctoral Associate position is...

jobs.rutgers.edu

Environmental regulation of mucosal-associated invariant T cells: Adding food for thought

Nutrients are important environmental factors that affect the functional responses of MAIT cells to challenge.

doi.org

Cytoplasmic NAD/H synthesis via NRK1 regulates inflammatory capacity and promotes survival of CD4+ T cells - Nature Communications

T cell activation requires major metabolic adaptation. Here authors find that in mice and humans, expression of the NAD/H-synthesis enzyme nicotinamide riboside kinase 1 (NRK1) increases in CD4+ T cel...

nature.com

VAC_11_2026 - 2 PREDOCTORAL RESEARCHER (Stem Cell Biology, Developmental Leukemia and Immunotherapy group) - Institut de Recerca contra la Leucèmia Josep Carreras

Join the Josep Carreras Leukaemia Research Institute and contribute to our mission of innovating and advancing the fight against leukaemia and other hematologic diseases.

careers.carrerasresearch.org

Lymphocyte alterations and elevated complement signaling are key features of refractory myasthenia gravis

A significant proportion of patients with myasthenia gravis (MG) remain refractory to standard immunosuppressive therapy, and biomarkers to help guide…

sciencedirect.com

Altered B cell activation contributes to the immunopathogenesis of childhood arthritis-associated uveitis - Nature Communications

Juvenile idiopathic arthritis (JIA) associated uveitis can cause vision loss in children, but mechanisms remain unclear. The authors here identify elevated CD19+IgD-CD27- double negative type 1 B cell...

nature.com

Single Cell Glucose Uptake Assays: A Cautionary Tale

Assays to monitor the metabolic state or nutrient uptake capacity of immune cells at a single cell level are increasingly in demand. One assay, used by many immunologists, employs 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose ...

pmc.ncbi.nlm.nih.gov

Fuelling the immune response IV: UK immunometabolism meeting 2026 | British Society for Immunology

immunology.org

A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALL

Dietary interventions show therapeutic potential in cancer, but systematic comparisons are lacking. We performed a dietary pan-amino acid dropout screen in an orthotopic model of NOTCH1-driven T-cell ...

biorxiv.org

CANTAO: guiding clustering and annotation in single-cell RNA sequencing using average overlap - Molecular Systems Biology

Single-cell RNA sequencing allows defining cellular identities based on transcriptional similarity using unsupervised clustering. However, a single clustering resolution may not yield groups of cells ...

link.springer.com

Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupus

Choi et al. show that pharmacologically restricting glycolysis improves the cellular, transcriptional, and metabolic machinery in murine lupus TFH cells. Transcript overlaps between TFH cells from lup...

cell.com

Fructose intake driven glycolysis-ROS-EGFR axis specifically promotes the generation and pathogenicity of Th17 cells - Nature Communications

Th17 cells play roles in maintaining immune homeostasis but also potentially harmful inflammatory processes. Here, authors show that homeostatic and pathological Th17 cells are distinct subtypes, resp...

nature.com

Postdoctoral Associate

Rutgers, The State University of New Jersey is seeking a Postdoctoral Associate within the Cancer Pharmacology Department at the Rutgers Cancer Institute. In this role, the Postdoctoral Associate will...

jobs.rutgers.edu

Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function

Given that reduced expression of ABHD11 within CD4+ T-cells is associated with remission in RA21, we sought to better understand the role of ABHD11 in T-cell biology. Firstly, we established the degree of ABHD11 protein expression in human CD4+ T-cells,...

nature.com

Mitochondrial protein represents promising target for autoimmune disease treatment

A new study led by Swansea University has revealed a new way to potentially treat certain autoimmune diseases by targeting a protein that helps regulate energy production in immune cells.

medicalxpress.com

Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Nature Communications

α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors repo...

nature.com

JCI - T-cell acute lymphoblastic leukemia exploits a neural proinflammatory pathway to colonize the meninges

jci.org

Canagliflozin synergises with serine restriction mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia

T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…

sciencedirect.com

Canagliflozin synergises with serine restriction mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia

T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…

sciencedirect.com