RNA doesn’t just encode information, it helps build cellular structure. This review explores how RNAs drive the formation of biomolecular condensates, shaping organization, regulation, and function across contexts #RNAbiology #PhaseSeparation #BiomolecularCondensates #CellBiology bit.ly/4mjjI8B

Excited to share our @natprot.nature.com paper on using RNA proximity labeling to map subcellular RNA transcriptomes. We’ve been working in this area for a while and wanted to create a resource paper to guide the uninitiated reader. rdcu.be/fblvI

APEX-seq maps transcriptome-wide subcellular RNA localization in living cells

Nature Protocols - This Protocol describes the transcriptome-wide labeling of RNAs in a particular subcellular compartment using proximity biotinylation by localized APEX2 enzyme and subsequent...

rdcu.be

This was a great chance to work with @IwasakiLabRiken to discuss the nearly perfect complementarity of Ribo-Seq and single molecule imaging studies of mRNA translation. I hope there are more studies in the future combining these two modalities to unravel translational regulation.

RNA Society Journal@rnajournal.bsky.social · 7mo ago

In this review we highlight how bridging single-molecule imaging and genome-wide Ribo-Seq experiments can shed light on complex mRNA translation dynamics across scales. #Translation #RiboSeq @tim-stasevich.bsky.social bit.ly/3LQ08Dc

Congrats to Sourav Ghosh (@souravsgw.bsky.social) of IIT Bombay & Kotaro Tomuro of RIKEN and The University of Tokyo - our 2025 Amon Young Scientist Award winners! They present Nov 6, 10 a.m. at the Koch Institute. MIT community & Amon Lab alumni welcome. buff.ly/nzhbwPp

Exciting new study from Iwasaki lab, led by Kotaro @ktomuro.bsky.social & Yuichi @u1-7no.bsky.social, that I was lucky to be part of! A new method reveals many mRNAs are locally translated. Too much for one tweet—check it out: www.biorxiv.org/content/10.1...

We developed APEX-Ribo-Seq, a method to map subcellular translation with spatial resolution. Using it, we profiled local translation in over 20 conditions!

bioRxivpreprint@biorxivpreprint.bsky.social · last yr.

Sequence grammar and dynamics of subcellular translation revealed by APEX-Ribo-Seq https://www.biorxiv.org/content/10.1101/2025.05.26.656194v1