Excited to share our paper, now out in @jcb.org! 🎉 Co-led with @georgegalea.bsky.social at embl.org, we uncover a new layer of spatiotemporal regulation of the #DNADamageResponse between the Golgi and the nucleus, revealing an active role of the Golgi in #DNArepair. doi.org/10.1083/jcb.... 📷by me ❤️

Spatiotemporal regulation of #DNArepair proteins between #Golgi and nucleus maintain genome stability. New study from George Galea @georgegalea.bsky.social, Karolina Kuodyte @kuodyte.bsky.social, Rainer Pepperkok @embl.org and colleagues: rupress.org/jcb/article/... #DNAbiology #Organelles

@georgegalea.bsky.social, @kuodyte.bsky.social, Pepperkok et al. reveal that RAD51C is anchored at the #Golgi by Giantin until DNA damage triggers ATM-dependent release & nuclear import, establishing the Golgi as a spatiotemporal regulator of nuclear #DNArepair rupress.org/jcb/article/...

Extremely happy to see this wonderful story out! 🔬 Here, we describe how Ki-67 anchors chromatin to nucleoli, leading them to acquire irregular shapes!!! 🫧🧬 This great story was led by Daja Schichler & Yuki Hayashi from the Cuylen Lab @embl.org link.springer.com/article/10.1...

Ki-67 shapes the nucleolus by anchoring chromatin via its amphiphilic properties - The EMBO Journal

The nucleolus, a membrane-less organelle essential for ribosome biogenesis, adopts variable shapes across cell types and in response to environmental conditions, yet the mechanisms regulating its morp...

link.springer.com

I’m very excited to share that our paper has been recently published in Cell Stem Cell! 🎉 🧫 In this study, using high-content imaging–based organoid screening, we discovered growth media conditions that drive differentiation into functional pancreatic acinar cells. doi.org/10.1016/j.st...

The group of @anne-grapin.bsky.social developed methods to create functional acinar cells, which are involved in the formation of pancreatic cancer. Rashmiparvathi Keshara, Karolina Kuodyte, and the TDS facility used image-based screen & robust analysis pipeline. www.mpi-cbg.de/news-outreac...

Making human pancreatic acinar cells

Dresden researchers develop novel methods to create acinar cells, which are involved in the formation of pancreatic cancer.

mpi-cbg.de

Online Now! High-content screening of organoids reveals the mechanisms of human pancreas acinar specification #stemcells

High-content screening of organoids reveals the mechanisms of human pancreas acinar specification

Keshara et al. conducted a high-content screen on pancreas organoids that identified 54 compounds affecting differentiation or morphogenesis. After validating 11 compounds, they focus on Gsk3A/B inhibitors, which, combined with FGF withdrawal, drive acinar cell differentiation, enabling future studies on these cells and their role in cancer initiation in humans.

dlvr.it

Delighted to share that my PhD work from the Hiiragi Lab is now published in Nature Cell Biology! We uncover the cellular mechanisms underlying pattern formation and how patterning robustness can be ensured during embryo development. Check out the full story: nature.com/articles/s41556-025-01618-9

Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness - Nature Cell Biology

Moghe et al. show that mouse embryonic primitive endoderm cells migrate towards the inner cell mass-cavity interface, depositing an extracellular matrix gradient that may guide migration. Primitive en...

nature.com