NIH head Bhattacharya is an ignorant quack (I have read his papers- they are atrocious crap that I'd fail a graduate student for producing). I would say that this is shameful, but shame is an emotion he is clearly incapable of feeling. Breathtaking sycophancy at every level in this administration.

Greg Folkers@gregfolkers.bsky.social · 3d ago

New HHS Hall of Heroes: John Snow, Ignaz Semmelweis, Joseph Lister, Alice Stewart, Herbert Needleman, Frances Kelsey, Rachel Carson, Jay Bhattacharya bit.ly/4hg6Rn0

I genuinely didn't think I could love Mamdani more. "That's very Norwegian." LOL.

Acyn@acyn.bsky.social · last wk.

Child: This is my first time meeting a mayor. Mamdani: Wow, have you ever met a prime minister? Child: No Norway PM Jonas Gahr Støre: *walks over*

Not the Onion.

AI staff complain of mental toll over fears of threat to society

Top researchers at Aisi, OpenAI, Anthropic and Google DeepMind report burnout and stress over developing powerful AI

ft.trib.al

Anyone else struck with a vaguely pressing feeling of need to rewatch the film Ex Machina?

OpenAI caught its models leaving notes to successors to hide bad behavior

OpenAI disclosed instances of GPT-5.6 Sol instructing future contexts to conceal mistakes and misaligned behavior, highlighting the growing challenge of detecting misalignment as increasingly capable ...

tech.yahoo.com

No surprises here. Biden's science advisor, Arati Prabhakar, has an MS in electrical engineering and a PhD in applied physics, both from Caltech. President pudding-brain replaced her with a Peter Thiel sycophant who has a BA in political science with a certificate in Hellenic studies.

Michael Kratsios - Wikipedia

en.wikipedia.org

Some nice news.

Space Telescope Science Institute@stsci.edu · 2w ago

“As a result of exquisite planning by our orbital dynamics team, brilliant execution by the operations team, and a precise launch from SpaceX, Roman has fuel for at least 22 years of potential science operations,” said Jamie Dunn, center director at NASA’s Goddard Space Flight Center. #NASARoman 🔭

Any of my chem peeps hear of the Ritonovir crisis? In 1998, a more stable polymorph of the drug spontaneously emerged, rendering the drug insoluble and inactive. The new polymorph is such a potent seed xtal, that the original polymorph became un-manufacturable as every factory became contaminated.

Excited to announce that our technology has passed an important milestone on its journey towards the clinic. Breakthrough device designation is intended to accelerate the development, assessment, and review of potentially life-saving technologies for which no approved or cleared alternative exists.

Nutromics Receives FDA Breakthrough Designation for Vancomycin TDM Patch | Nutromics posted on the topic | LinkedIn

Nutromics has been granted FDA Breakthrough Device Designation for our first product in development: a wearable patch for vancomycin therapeutic drug monitoring.   The FDA's Breakthrough Device Progra...

linkedin.com

Strong Nuremberg vibes in Dallas.

Aaron Rupar@atrupar.com · 3w ago

"Please right your right hand. I pledge to the greatest president in history that loves us so much he can't even breathe" -- in extremely culty scene, Trump has his supporters pledge to him that they will vote, then tells them they will "go to hell" if they don't Here's the full sequence:

Today I learned that the co-chair of the AfD, who, like her party, is vehemently anti-immigrant and against same-sex marriage, is a lesbian whose wife hails from Sri Lanka. A few years ago such hypocrisy would have honestly surprised me. It no longer does.

Berin Szóka@berinszoka.bsky.social · 3w ago

Photo of the decade: AfD leader Alice Weidel

I don't know why Trump wants to rename the moon when Uranus is already named after him. A real LUNAtic 🤣

Today is Ruby Bridges' 72nd birthday.

A top-shelf paleontologist-dad joke.

Harry Turtledove @hntdove.bsky.social · 3w ago

I shit you not.

Nutromics' efforts to get our life-saving, cost-cutting molecular sensor technology into the hands of clinicians are going so well that I suffered from "FOMO." I'm thus happy to report that Jade and I have relocated to Melbourne, where I am serving as both Nutromics' CSO and a Prof at La Trobe Uni.

We're excited to share that Prof Kevin Plaxco is joining Nutromics as Chief Scientific Officer. Prof Plaxco invented the DNA-based sensing technology our platform is built on. He has had a long… ...

We're excited to share that Prof Kevin Plaxco is joining Nutromics as Chief Scientific Officer. Prof Plaxco invented the DNA-based sensing technology our platform is built on. He has had a long assoc...

lnkd.in

🎯💯🙃

NIH Simplifies Grant Scoring To 👍 🤷‍♂️ 😂

BETHESDA, MD—The National Institutes of Health announced Tuesday that it would replace its 50-year-old numerical scoring system with a streamlined three-emoji format, in which grant applications will ...

inpreparation.substack.com

From the Facebook

Honestly feels weird, but, OK: 3 new R01s since November (you do not want to know how many submissions), many important papers in 2026 (e.g., first clinical trial, first 1 week in vivo duration of our tech, and first two "we did novel science with the tech" papers). And the company is doing well.

Bruce Hamilton@bahome.bsky.social · last mo.

💯%. I want to read about your preprint, thesis, paper, grant, promotion so much more than all the fuckery and rageposts that I will also see anyway.

Juvenile, I admit it, but still, I laughed. And then shared it.

Ron Filipkowski@ronfilipkowski.bsky.social · last mo.

Ted didn’t notice the name of the account who posted this Dolly clip he retweeted until it was much too late. He finally deleted it after he was made aware.

A sweetly touching tribute.

WuTangIsForTheChildren@wutangforchildren.bsky.social · last mo.

Buckingham Palace band playing 9 to 5 for Dolly Parton

So sad that we've lost both Dolly and Paul Rubens. I'm happy, though, to know that Chairry is retired and living her best life in Boca Raton.

Ken Plume@kenplume.bsky.social · 2mo ago

Pee Wee Herman & Dolly Parton singing a duet? Here ya go...

Reminder: Dolly Parton helped fund the Moderna vaccine for COVID.

Dolly Parton, who helped fund the Moderna vaccine, gets a ‘dose of her own medicine.’ (Published 2021)

The country music star broke into song before she was inoculated, and urged her fans to “get out there and get your shot.”

nytimes.com

Example number 2,325,478 of the idiocy of the current US administration: an F1 race on streets with traffic calming measures.

Rodger Sherman@rodger.bsky.social · last mo.

The Trump-endorsed IndyCar race on the DC streets into a great unintentional advertisement for the effectiveness of raised crosswalks as a traffic calming measure

A delightfully and quintessentially Aussie take on Canada (rightfully) walking away from the negotiating table with the deal-welcher-in-chief.

KING CARNEY ACTIVATES KONG MODE WITH ZERO FUCKS

Carney Reads the Clock Like a Pro Wrestler

ifloz.substack.com

"Corruption appears to visit the White House in 50-year cycles...exposure and retribution inoculate the presidency against its latent criminal impulses for about half a century. Around ... 2023 the American people will be well advised to go on the alert and start nailing down everything in sight."

Richard Nixon's Runaway Presidency

“Watergate is potentially the best thing to have happened to the presidency in a long time.”

theatlantic.com

I admit, Ed Koch had a certain something. But Mamdani is hands down the most adorable NY City mayor of my lifetime. I will die on this hill.

Mayor Zohran Kwame Mamdani@mayor.nyc.gov · last mo.

Could AI do this TAMBIEN?

Trump is just so pathetic. (And yes, I checked: this is a real post on his Truth social account.)

@cubesart.bsky.social: has anyone ever ported Conway's Game of Life onto a Rubix Cube?

Matt Henderson@matthen.com · 2mo ago

Game of Life on Penrose tiles

I'll never steal your pen.

Team Talarico@teamtalaricohq.bsky.social · 2mo ago

NEW AD: 14 years ago today, Ken Paxton stole someone's $1,000 pen. Today, Ken Paxton’s pen victim is endorsing James Talarico.

They're at it again. "The framework calls for NIH Institutes...to consider peer review outcomes in the context of their and NIH's priorities, strategic plans, and budgets, instead of relying on funding paylines to develop pay plans..." Upload comments here: rfi.grants.nih.gov?s=6a2b1c22c3...