LabEx Revive

@labexrevive.bsky.social

French scientific consortium focus on #stemcellresearch and regenerative biology since 2011 @institutpasteur 🇫🇷 #ageing #development

⏳ Final Call! The deadline to apply for the #ASCBcourse is April 5! 🔬 Master cutting-edge #stemcell techniques 🎓 Learn from world-class experts 📅 June 23 - July 04, 2025 🚀 Don’t miss this unique hands-on experience! Apply now: urlr.me/dGUhxY #ResearchTraining #LastChance

Pasteur courses

urlr.me

LabEx Revive@labexrevive.bsky.social · 2y ago

📣 Register to the 12th Advances in Stem Cell Biology Course #ASCBcourse at the @institutpasteur @PasteurEdu. Hands-on training in different models, embryonic stem cells, iPS cells and much more on #StemCells. 🕘June23-July04, 2025 👉 qrfy.io/VEcoKQpGfV

Share your science moments with us for a chance to be part of ISSCR’s educational and marketing materials! Whether it is colorful microscopy images or candid shots of your lab mates, we want to see it all! 📸 Submit here 👉 bit.ly/3Xag0Tr

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The ISSCR Standards Task Force is meeting in Edinburgh, UK to discuss and update the Best Practices for PSC-Based Therapies document, based on feedback from external peer review. Stay tuned to see what updates come out of this meeting! Learn more👉 bit.ly/4aZ8wbu

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Late-breaking poster abstract submission is now open for the #ISSCR2025 Annual Meeting! Showcase your latest work, get valuable feedback, and connect with collaborators or future employers at The Global Stem Cell Event. Abstracts due 19 March 2025👉 bit.ly/4ePsyGq

Congrats to @zenlabpasteur on their new BioRxiv article! 🎉📚 Uncovering the secrets of quiescent neural stem cells in the zebrafish brain💡🧬 Read all about it:#stemcells #Neuroscience #zebrafish #LabExRevive #France2030 x.com/zenlabpasteur/… biorxiv.org/content/10.110…

Notch signaling blockade links transcriptome heterogeneity in quiescent neural stem cells with their reactivation routes and potential

In the vertebrate brain, neural stem cell (NSC) quiescence is necessary for stemness maintenance. Using single cell RNA sequencing (scRNAseq) in the zebrafish adult telencephalon, we identified different molecular clusters of quiescent NSCs, interpreted to sign different quiescence depths( [1][1] ). Here, we show that these clusters, when challenged in vivo with an inhibitor of Notch signaling -a major quiescence promoting pathway-, unfold different behaviors. Notably, deeply quiescent NSCs with astrocytic features display a unique activation phenotype that combines the maintenance of astrocytic markers with the rapid upregulation of activation and neuronal commitment genes, reminiscent to murine periventricular astrocytes activating upon lesion. In contrast, an NSC cluster predicted to be in the deepest quiescence state resists Notch blockade, and we demonstrate that the transcription factor Nr2f1b mediates this resistance to activation in vivo . These results together link the molecular heterogeneity of quiescent NSCs with bona fide biological properties and their molecular regulators. ### Competing Interest Statement The authors have declared no competing interest. [1]: #ref-1

biorxiv.org