‪doi: doi.org/10.1038/s414... 📣 Our study is now out in Nature Communications detailing that the type I interferon pathway is suppressed by HUSH in early human development: Its complete epigenetic lockdown!! Incredible work from James Holt 📣 😎

How do pluripotent stem cells resist harmful interferon responses to safeguard development? Through total epigenetic lockdown of ligands, sensors and effectors of IFN-I. In our preprint, James Holt shares his PhD discoveries on the ground state of immune evasion 😊: www.biorxiv.org/cgi/content/...

Epigenetic lockdown of type I interferon sensing and signalling in human pluripotent cells.

The Human Silencing Hub (HUSH) complex safeguards genome integrity in human somatic cells by repressing transposable elements and regulating type I interferon (IFN-I) induction. In early development, ...

biorxiv.org

What's on the horizon of cancer immunotherapies? Understanding epigenetic checkpoints, we say 😊: news.cancerresearchuk.org/2025/09/11/l...

Level-up: Looking to epigenetics for the next immunotherapy breakthrough - Cancer Research UK - Cancer News

Checkpoint inhibitors have utterly changed the immunotherapy landscape – but there could be a different kind of checkpoint just waiting to be targeted...

news.cancerresearchuk.org

Looking forward to this meeting this week: Transposable elements are controlling elements in health and disease, genetics.org.uk/events/the-r... organised by the Genetics Society 😊

The real point is control: transposons as controlling elements in evolution, development and disease | Genetics Society

This three-day conference will run from Wednesday 20th to Friday 22nd November 2024 in Leicester. Background: When Barbara McClintock first described transposable elements in the 1940s, the scientif...

genetics.org.uk

Please register for the course on Transposable elements in #genomics and #datascience. We will be sharing the magic of #nanopore long reads for #transposon expression #tesky

I’m happy to announce that I’ve been promoted to Professor! 🥳 I’m so grateful to everyone who has supported me, to my amazing lab members and to all who have made my scientific journey fun along the way ☀️. Thank you Queen Mary University!

I am thrilled and incredibly proud that recent PhD student @Liane Fernandes from my lab @QMUL has won a prestigious EMBO Fellowship! Exciting science ahead ❤️ 🏆

How do tumours evade destruction by the immune system? We are recruiting two postdocs (wet lab/dry lab) to shed light on epigenetic checkpoints of anti-tumour immunity in lung cancers, funded by CRUK. Please get in touch to find out more! www.qmul.ac.uk/jobs/vacanci... www.qmul.ac.uk/jobs/vacanci...

I am honoured to receive a Programme Foundation Award from Cancer Research UK on epigenetic regulation of immune evasion in non-small cell lung cancer. Thanks to my co-investigators, collaborators, mentors, lab & @qmulepigenetics.bsky.social for supporting this exciting translational project.

Please join us for the @QMULepigenetics seminar by Kristian Helin from @icr_london 11th Jan. 15.30GMT. venue: Derek Willoughby Lecture Theatre, at our Charterhouse Square campus. or online link at qmulepigenetics.com/webinars

Dear TE family, it is time! The early-bird registration ends January 15th already! Abstract for talks ends February 15th! Start procrastinating by doing something useful: register to #icte2024 ! See you soon! #transposon

Enlightening review from @KathleenHBurns lab: genesdev.cshlp.org/content/37/2...: LINE-1 activity and jumping contributes to genetic instability in cancer and understanding LINE-1 deregulation could lead to new therapeutic opportunities. A must-read.

Elegant preprint identifying mutually exclusive targeting of HUSH1 vs. HUSH2 chromatin complexes for silencing dangerous LINE-1 elements in the human genome: www.biorxiv.org/content/10.1...