If an action results in error, each neuron requires an individualized teaching signal that guides change in its output. This is the credit assignment problem of learning. Are there neurons in the brain that can compute such a sophisticated teaching signal? Yes. www.biorxiv.org/content/10.6...

Climbing fibers encode the gradient of a loss function for the cerebellum

Neurons in the brain are often many synapses away from motoneurons, yet if a movement results in error, each distant neuron needs a teacher that considers its specific contribution to production of th...

biorxiv.org

How does sleep consolidate muscle memories? New research from @mstephensonjones.bsky.social lab & @gatsbyucl.bsky.social in @natneuro.nature.com reveals that motor-skill memories are replayed in the striatum during sleep, independently of the hippocampus. www.sainsburywellcome.org/blog/muscle-...

Muscle memories: how does sleep produce consolidation? | Sainsbury Wellcome Centre

Sleep not only makes us feel better, but it’s vital for helping us form memories and learn new skills. For many years, neuroscientists have studied how the brain consolidates episodic memories during ...

sainsburywellcome.org

Our new paper on how mice become experts in a visual spatial attention task - after just 18 days of training! 🐭👁️🧠🔦 Lots of new findings made possible by standardized behavioral procedures and a fantastic team of 👩‍🔬👨‍🔬. Open access, all data + code posted. Check it out 👇

Cell Reports Methods@cp-cellrepmethods.bsky.social · 4w ago

A standardized and reproducible behavioral framework to elicit multiple aspects of visual spatial attention in mice

on the 2nd day pm time at #fens2026 you think of skipping the posters & enjoying Barcelona. BUT the temptation of seeing our posters will keep you in the poster hall 😆 All new & all on frontal cortex in learning by Sandra Tan, Marko Tvrdic, Yuliia Shevchuk & @huriyeatg.bsky.social et al, No94,95,96

Awesome results from @fluketc.bsky.social @dudman.bsky.social and team, both for dopamine field and for all that train animals in tasks www.science.org/doi/10.1126/...

Reward magnitude determines reinforcement learning efficiency

Standard animal learning studies minimize individual reward magnitudes to maximize the repetitions of reinforced behaviors. We investigated how reward magnitude influences initial learning across five...

science.org

big fomo for @dopaminesociety.bsky.social next week but excited that @jessicamoretti.bsky.social and @matthiasfritsche.bsky.social from the lab attending to present what we have been up to

Excited to share our new paper published in Nature Communications! rdcu.be/fh6ty We show that deep layers of the superior colliculus identify the salience of conditioned visual stimuli and drive dopamine responses during classical conditioning.

Very interesting stuff here

Eduardo Maristany de las Casas@maristanye.bsky.social · 3mo ago

1/10 When the going gets tough, the dendrites get going. Here is a summary on our new paper just published in @science.org on flexible learning in frontal motor cortex. With @mattlark.bsky.social 🔬. #neuroskyence #neuroscience 🔗 doi.org/10.1126/scie...

We have new a new doctor in the lab 🍾🍾🎉Congratulations @neurorussell.bsky.social for successful viva today at Oxford @oxforddpag.bsky.social

Amazing study and the coolest results (from my point of view!) is that LC norepinephrine neurons projecting to the frontal cortex encode reward prediction error

Jeremiah Cohen@jeremiahycohen.bsky.social · 4mo ago

Delighted to share our discoveries about one of the brain's neurotransmitter systems: www.biorxiv.org/content/10.6... Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1

I am livid that after less than a day, Vance et al are back empty-handed. "Marathon" talks?? They didn't even sleep on it and try again! Many thousands of lives, the world economy and world hunger, and more, hang in the balance, and they stopped trying after less than a day?? What a rotten failure.

We’re recruiting! Exciting opportunities in our lab supported by a @wellcometrust.bsky.social Discovery Award. • Postdoctoral researchers • Research assistant/PhD students Join us to study how neural circuits drive decision-making. Deadline 26/04 Learn more and Apply here: rezavallab.org

Carolina Rezaval@crezaval.bsky.social · 4mo ago

Deeply honoured to have been awarded a Wellcome Trust Discovery Award to study how competition is encoded in the brain. This builds on the discoveries of outstanding past/present lab members. Grateful to mentors/collaborators/colleagues for their support. We are recruiting postdocs/PhD students.

100+ year old Pasteur Institute in Tehran was a premier infectious disease research institute and vaccine manufacturer It is a reason Iranian kids like me born in 60s had access to measles vaccines soon after they were developed in the west

Athena Akrami@athenaakrami.bsky.social · 4mo ago

Pasteur Institute of Iran, founded in 1920 now destroyed by Israel-US bombing😞 It played a pivotal role in developing vaccines & public health services, for over a century, now gone😞 A few days ago a pharmaceutical plant was bombed, accused of making anesthetic fentanyl #War #PasteurInstituteIran

bombs falling to plant democracy! , but instead fertilising despair and taking lives… writing right after hearing that a few days ago bombs landed some 50 m from my father’s office ….

Reza Shadmehr@rezashadmehr.bsky.social · 5mo ago

Today I received a note from a grad student who lives in Tehran. Her note gives you firsthand experience of what it’s like to live in a city that is being bombed, and what it’s like to be young and feel despair about your future. rezashadmehr.blogspot.com/2026/03/hope...

Actually the view from my office just got more interesting, as the official celebrations of the 200th anniversary now include a pirate projection saying "Free Palestine". Regardless of opinions, may UCL enjoy 200 more years of freedom of speech.

RA job alert. We are looking for a fearless experimentalist to join our experiments on cortical neuromodulators during visually guided learning, lead by @michael-lynn.bsky.social . Opportunity to learn 2p imaging, design and conduct experiments. RT plz. Apply here: my.corehr.com/pls/uoxrecru...

There is a new Postdoctoral Research Associate position available in my group, to work on computational analysis of human neuroimaging workflows to develop robust, interpretable and scalable biomarkers of cognitive brain health. Closing date 10th Feb 2026. www.imperial.ac.uk/jobs/search-...

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

imperial.ac.uk

Out today in Neurophotonics, we show that cross-talk between the imaging laser and opsin in all-optical experiments can affect response dynamics beyond what has been accounted for. Imaging conditions subthreshold for evoking spikes can accelerate opsin desensitization: doi.org/10.1117/1.NP...

We're running a 5th edition of the always-exciting UCL Summer School on Consciousness and Metacognition this year, 8th-10th July 2026 in London. Accommodation and travel expenses are covered. For more information and how to apply, check out metacoglab.org/summer-schoo...

This one from @kepecslab.bsky.social and Song Hu lab is awesome: www.nature.com/articles/s41...

New preprint. We show that in addition to reward prediction errors (RPEs), dorsal striatal dopamine signals encode sensory prediction errors (SPEs), the difference between sensory prior & observed stimulus. www.biorxiv.org/content/10.6...

Dorsal striatal dopamine integrates sensory and reward prediction errors to guide perceptual decisions

Perceptual decisions are shaped by expectations about sensory stimuli and rewards, learned through sensory and reward prediction errors. Dopamine is known to convey reward prediction errors that shape...

biorxiv.org

We tend to think of neurons as either excitatory or inhibitory, but some neurons chemically inhibit their downstream targets while electrically exciting their neighbors. What is gained by having an inhibitory neuron excite its neighbor? www.biorxiv.org/content/10.6...

Please repost widely. @vanderhaeghenp2.bsky.social and I are hiring a postdoc with expertise in sensory physiology and in vivo circuit imaging/manipulation. The project centers on human-specific brain development and SYNGAP1-related disorders. Call closing soon—apply ASAP jobs.vib.be/j/119852/pos...

Postdoctoral Fellow / PhD Student in Systems Neuroscience - VIB

The Laboratory of Cortical Information Processing | Vision to Action at NERF (www.nerf.be) invites applications for a Postdoctoral Fellow or PhD Student to work on a new research project funded by the...

jobs.vib.be

concise and informative review article on corticostriatal pathways in sensory process by @giladsilberberg.bsky.social et al . I find myself looking into it frequently and learn/cross check a new thing every time : www.sciencedirect.com/science/arti...

Corticostriatal pathways for bilateral sensorimotor functions

Corticostriatal pathways are essential for a multitude of motor, sensory, cognitive, and affective functions. They are mediated by cortical pyramidal …

sciencedirect.com

We look forward to discussing these with you all #SfN25, #SfN2025

Our lab is looking for a postdoc! We have interesting projects and cutting-edge techniques such as Neuropixels Opto, Light Beads Microscopy and more. We would be delighted to receive your application. Deadline is 25 November 2025. More info here: www.ucl.ac.uk/cortexlab/po...

Out today at Neuron, our experiments show that frontal cortical representation of economic variables is jointly determined by spatial organization and downstream connectivity of neurons, revealing a structured, multi-scale code for economic variables. www.cell.com/neuron/fullt...

All-optical experiments are great but @neurorussell.bsky.social found that opsin desensitization due to cross-talk between the imaging laser and the opsin causes major issues. These can be ameleorated with long inter-stimulus intervals & short imaging doses. All here: www.biorxiv.org/content/10.1...

Desensitization of opsin responses during all-optical interrogation depends on imaging parameters

Significance The combination of two-photon calcium imaging and two-photon optogenetic stimulation, termed all-optical interrogation, provides spatial and temporal precision when recording and manipula...

biorxiv.org

Looking for a PhD next year? Want to come and work on the next generation of OPM-MEG/EEG biomarkers in computational psychiatry? Apply for our MRC iCase studentship with @mkflugge.bsky.social, collabs with @lilweb.bsky.social + industrial placement at P1Vital: www.medsci.ox.ac.uk/study/gradua...