Laura Ratcliffe

@lauraratcliffe7.bsky.social

Consultant Nephrologist | Views my own; repost does not imply agreement

#UKKW26 is officially underway! Day 1 highlights include: 🧠 11:30–13:00 | Opening Plenary: Hypertension (Prof Ian Wilkinson), O’Donoghue Lecture (Prof Smeeta Sinha), Advanced Practice session (Paula McLaren) 💬 14:00–15:30 | Bridging the Gap: CKD & Primary Care Tag us/ follow #UKKW26 for updates!

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IgA nephropathy is the most common cause of immune-mediated glomerular disease worldwide. 📄 This Review summarizes the pathophysiology, epidemiology, clinical presentation, diagnosis, treatment, and prognosis of primary IgA nephropathy in adults. ja.ma/47bIhht

Illustration of IgA Nephropathy pathophysiology from JAMA. Four-hit hypothesis shows: 1) Aberrant IgA1 production; 2) Gd-IgA1 entering circulation; 3) Immune complex formation; 4) Complex deposition in glomerulus. Published online January 26, 2026.