Laurent Sheybani
@laurentsheybani.bsky.social
Epilepsy Sleep Electrophysiology Hiking - Cycling - Swimming - Music Associate Editor @ Brain Comms https://academic.oup.com/braincomms
🐌 🌊 🧠 ICCN 2026 What does slowing mean in EEG ? Good, bad, both, neither? Tomorrow Friday 9:20 AM at Getsamani auditorium, I will discuss focal slowing, its relationship with epilepsy and mechanisms of generation. The session will also host Stefano Meletti, Stephan Schuele, and Margitta Seeck.
🗞🧠🔊 If you have a neurology or psychiatry manuscript that you would like to publish in an ambitious journal, Brain Communications might be its home ! 📊⛓️💥🔬 We will promote its translational aspect --> check our editorial, written with EiC Prof. David Belin: doi.org/10.1093/brai...
🚨 Great scientific commentary by Christos Lisgaras --> academic.oup.com/braincomms/a... High frequency oscillations in neurodegenerative disorders. Have a look !
High frequency opportunities for Alzheimer’s disease
This scientific commentary refers to ‘High-frequency oscillations in epileptic and non-epileptic Alzheimer's disease patients and the differential effect o
academic.oup.com
We are hiring ! 👩🏼🎓👨🎓🧑🏼🎓👨🏿🎓👩🏿🎓👩🎓 I am looking for a motivated person interested in a PhD in basic neuroscience, for a project at the edge between epilepsy and sleep. If you are interested, check the job announcement: jobs.unige.ch/www/wd_porta...
Assistant-e (A2) (6548)
jobs.unige.ch
This asymmetry is highly patient-specific and supports the hypothesis that generalized discharges are shaped by delimited areas of cortex. doi.org/10.1111/epi.... #epilepsy #epilepsia #ILAE #amplitude #discharges #EEG #generalized #symmetry
Thrilled to have been awarded an Ambizione grant from the @snsf.ch ! I will work under the auspices of Pr Serge Vulliémoz, Pr @anitaluthi.bsky.social and collaborate with Pr Matthew Walker (UCL), Dr Daniel Bush and Dr Tawfeeq Shekh-Ahmad for a project on epilepsy and sleep.
Deep learning for epilepsy ! An impressive work by Sundrani and colleagues demonstrates the ability of convulational neural network to predict seizure onset zones --> doi.org/10.1111/epi....
Deep learning on brief interictal intracranial recordings can accurately characterize seizure onset zones
Objective Epilepsy is a debilitating disorder affecting more than 50 million people worldwide, and one third of patients continue to have seizures despite maximal medical management. If patients' se...
doi.org
Interneurons promotes microglial activation, ultimately leading to phagocytosis of inhibitory synapses --> part of the mechanism of temporal lobe epilepsy? doi.org/10.1038/s415...
GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy - Nature Neuroscience
The microglia–neuron interactions contributing to neuronal hyperexcitability are unclear. Here, the authors show how GABA and C3 signaling coordinate microglial engulfment of inhibitory synapses, driv...
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Just published my first paper! Really grateful to everyone at the plasticity lab @oxcin.bsky.social who made this possible. huge thanks to my co-authors — couldn’t have done it without you. If you want to check it out: 📄 paper: www.nature.com/articles/s41...
Sleep regularity index as a novel indicator of sleep disturbance in stroke survivors: a secondary data analysis - Scientific Reports
Scientific Reports - Sleep regularity index as a novel indicator of sleep disturbance in stroke survivors: a secondary data analysis
nature.com
Pint of Science in Geneva! This week. Program here: pintofscience.ch/events/geneva @pintofscience.ch
Geneva
Explore Pint of Science Switzerland events in Geneva
pintofscience.ch
doi.org/10.1038/s415... @anitaluthi.bsky.social
Autonomic physiological coupling of the global fMRI signal - Nature Neuroscience
The brain and body are necessarily connected. Here the authors show that brain blood flow and electrical activity are coupled with systemic physiological changes in the body.
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Thorough electrophy study on cortical stimulation --> www.nature.com/articles/s41.... Fascinating to see this complex network elicited by 'artificial' stimulation. Well done @simonerusso.bsky.social and team!
Thalamic feedback shapes brain responses evoked by cortical stimulation in mice and humans - Nature Communications
Neural mechanisms underlying thalamic contributions to evoked potentials by brain stimulation, which has been widely used for therapeutic interventions, are not fully understood. In this translational...
nature.com
Encouraging phase 2 trial in fronto-temporal dementia ->
Brain Communications@braincomms.bsky.social · 2y agoAssogna et al. report that co-ultramicronised palmitoylethanolamide + luteoline slowed cognitive decline in FTD patients in a Phase 2 trial, showing promise for future treatment. Please read at: buff.ly/VlC9Kdd #FTD
Excited to take part in tomorrow's webinar organized by the Young Epilepsy Session (YES) of the International League Against Epilepsy (ILAE). I will be discussing mechanisms of generation of HFOs and why this is important for clinical practice. @ilae-epilepsy.bsky.social
Christos Lisgaras@chrislisgaras.bsky.social · 2y agoJoin us next week for an @ilae-epilepsy.bsky.social webinar on High Frequency Oscillations! Dr. Sheybani @laurentsheybani.bsky.social and Dr. Jacobs will talk all about HFOs in epilepsy. #HFOnews Register here: docs.google.com/forms/d/1e-x...
Disrupting synaptic transmission affects sleep-wake dynamic --> www.cell.com/current-biol...
Deficient synaptic neurotransmission results in a persistent sleep-like cortical activity across vigilance states in mice
Using a mouse model of altered neurotransmission (Vamp2rlss), Guillaumin et al. show that differences typically observed between vigilance states in neural dynamics and spectral signatures can be mark...
cell.com
At the MicMac conference in Toulouse, listening to talks on HFOs, and look what comes out in Brain Communications: doi.org/10.1093/brai...
Spikes on ripples are better interictal biomarkers of epilepsy than spikes or ripples
Fabbri et al. report that spikes on ripples are promising biomarkers for identifying the epileptogenic zone and predicting outcome in drug-resistant epilep
doi.org
Brain Communications@braincomms.bsky.social · 2y agoFabbri et al. report that spikes on ripples are a promising biomarker for predicting the epileptogenic zone and outcome in drug-resistant epilepsy, especially when fast ripples are absent. They show high accuracy in surgical planning. Please read at:https://buff.ly/cKkDOmW
Mosaicism in the brain: doi.org/10.1093/brai... Complexity should be seen as an opportunity...
Analysis of DNA from brain tissue on stereo-EEG electrodes reveals mosaic epilepsy-related variants
D’Gama et al. studied a prospective patient cohort being evaluated with stereo-EEG electrodes for seizure localization. They identified somatic mosaic vari
doi.org
Coupling of spindles to slow waves is important for memory, but this is disrupted in people with epilepsy --> doi.org/10.1111/epi....
Widespread decoupling of spindles and slow waves in temporal lobe epilepsy
Objective Memory impairment is common in people with temporal lobe epilepsy (TLE). Recent studies in healthy subjects showed a positive correlation between sleep spindles coupled to slow waves (SWs)...
doi.org
Exciting work where we address the mechanisms underlying long held epidemiological associations between epilepsy and sleep. Thanks to all co-authors: Birgit Frauscher, Christophe Bernard and Matthew C Walker. Thanks to my funding: @snsf-ch.bsky.social Guarantors of @brain1878.bsky.social
Nature Reviews Neurology@natrevneurol.nature.com · 2y agoNew online! Mechanistic insights into the interaction between epilepsy and sleep https://bit.ly/4ixu2qu
Is sleep the worst enemy of epilepsy? Is it promoting or preventing seizures? And how? We present recent mechanistic insights on the interaction between epilepsy and sleep in a review published today in Nature Reviews Neurology: doi.org/10.1038/s415... @natrevneurol.bsky.social
Mechanistic insights into the interaction between epilepsy and sleep - Nature Reviews Neurology
Epidemiological evidence has demonstrated associations between sleep and epilepsy, but we lack a mechanistic understanding of these associations. In this Review, Sheybani et al. consider the associati...
doi.org
Thalamic activity during wake and sleep in 121 people with epilepsy --> academic.oup.com/braincomms/a...
Interictal waking and sleep electrophysiological properties of the thalamus in focal epilepsies
Epilepsy is a cortico-subcortical network disorder. By analyzing thalamo-cortical relationships in 121 patients through stereotactic-EEG, Biagioni et al. i
academic.oup.com
Can you learn while sleeping? Does sleep help you solve problems? What is the effect of sleep on brain metabolism? --> my last editorial @braincomms.bsky.social doi.org/10.1093/brai... Sleep is not a homogenous state - just like wake. Asking the role of sleep is as fair as asking the role of wake!
pendingpublications
Pending Publication
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How can we improve the chance to record seizures during intracranial monitoring of people with drug resistant epilepsy? Interesting to see that sleep deprivation does not contribute (reminds me of the works by Malow!) --> doi.org/10.1111/epi....
doi.org
Pupil size as an index of sleep states --> www.nature.com/articles/s41... See also www.nature.com/articles/s43... Sleep goes beyond the classical NREM/REM stages and pupil size might be a candidate tracker of these more subtle states.
Pupil size reveals arousal level fluctuations in human sleep - Nature Communications
Arousal levels regulate sleep, but accurate noninvasive measures are lacking. Here, a novel method is introduced to track pupil-indexed arousal levels during human sleep, revealing pupil size changes ...
nature.com
Very interesting paper by Alfonsa et al. @currentbiology.bsky.social. Switch in EGABA associated with long period of wakefulness shapes LTP. @vyazovskiy.bsky.social doi.org/10.1016/j.cu...
Redirecting
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Great work on substantia nigra and locus ceruleus microstructural abnormalities in REM sleep behavior disorder and Parkinson's disease. Now in @braincomms.bsky.social doi.org/10.1093/brai...
Substantia nigra and locus coeruleus microstructural abnormalities in isolated rapid eye movement sleep behaviour disorder and Parkinson’s disease
Pasquini et al. explore microstructural abnormalities in LC and SN through neuromelanin and diffusion MRI in Parkinson’s disease and iRBD. They also show a
doi.org
The inferior fronto-occipital fasciculus: from structural to functional anatomy. Here is a great review in @brain1878.bsky.social doi.org/10.1093/brai...
The inferior fronto-occipital fasciculus: bridging phylogeny, ontogeny and functional anatomy
Giampiccolo et al. review the anatomy and function of the inferior fronto-occipital fasciculus. They propose that it plays a role in visual cognitive contr
doi.org
High-density electrocorticography in epilepsy surgery --> doi.org/10.1111/epi....
Implementing intraoperative high‐density electrocorticography during epilepsy surgery
Objective In intraoperative electrocorticography (ioECoG)–tailored epilepsy surgery, standard low-density (LD) electrode grids (16–20 electrodes, 10 mm inter-electrode distance) are used, covering ±.....
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