"Reaction hijacking of enzymes to generate potent therapeutic modulators in situ" spkl.io/63328A2hIp @leanntilley.bsky.social & colleagues @cp-trendsbiochem.bsky.social

Can enzymes be made to self-destruct for therapeutic purposes? “Reaction-hijacking of enzymes to generate potent therapeutic modulators in situ”. Very pleased that our Review is part of the 50th anniversary special edition of Trends in Biochemical Science. doi.org/10.1016/j.ti...

Amazing Public Lecture by Nobel Laureate Donna Strickland, Nobel Prize in Physics in 2018, at RMIT’s Capitol Theatre. Strickland pioneered chirped pulse amplification for lasers, enabling innovations such as laser eye surgery. She gave an inspirational talk about her love of photons.

Very pleased to participate in an amazing Women in Parasitology session today as part of the Australian Society for Parasitology (@AS_Para) 2025 Conference. Thanks very much to Facilitators: Ghizal Siddiqui (@G__Siddiqui) and Hayley Bullen.

I thoroughly enjoyed attending the Symposium for the 50th Anniversary of the WEHI Parasitology and Infectious Diseases Division. It was great to meet up with friends and colleagues, such as Prof Emeritus Robin Anders and Prof William Pomat, Director of the PNG Institute of Medical Research.

Congratulations from all the Tilley Lab to Nutpakal Ketprasit (@nkprst) who submitted his thesis today on reaction hijacking of tRNA charging enzymes of Plasmodium & bacteria. This work will guide development of new treatments. Co-supervised by Stanley Xie and Stuart Ralph (@sturalph). @UniMelb

Thanks to the amazing and inspirational International Women's Day #IWD2025 Morning Tea Panel organised by the School of Biomedical Sciences @UniMelb. “It takes a village to raise a successful woman scientific leader”. Great buzz of collaboration and support at the event.

Congratulations to Tayla Field, Stawell Secondary College, 2025 winner of the Chris & Marli Tilley Scholarship. Thanks to the Program run by Andrew McGuickan CEO. #Youthrive_Victoria is an amazing organisation supporting young rural and regional Victorians and their communities.

A fantastic meeting #LorneProteins2025

Renae Ryan@renaeryan.bsky.social · last yr.

Beautiful sunrise for the last day of the 50th Lorne Conference on Protein Structure and Function. Thanks to all the speakers, organisers and participants for making this another fabulous meeting! Save the date for next years meeting: 8-12 Feb, 2026. @lorneproteins.bsky.social

I had the great pleasure and honour of Chairing a Special session @LorneProteins. A History of the Lorne Conference on Protein Structure and Function. The event marked the 50th Anniversary. 5 decades of Lorne-inspired protein science in Australia - remembered by 5 amazing colleagues.

Inspirational women discussing science @LorneProteins and life at 7.30 am in Lorne, as part of the #GWB breakfast network.

Congratulations to @FrancesBiophys on the award of the 2025 Leach Lecture Medal of the Lorne Proteins Conference. Frances gave an inspirational talk about NMR and of a life lived fully. What a wonderful role model for women in science! @LorneProteins

Great talk from Hannah Shafaat UCLA on how to make a minimal metaloprotein @lorneproteins.bsky.social

"Two-thirds of the staff of the President’s Malaria Initiative, an organization founded by former President George W. Bush, have been fired, including some of the most senior and respected scientists working on malaria control in the world..." www.nytimes.com/2025/02/01/h...

Health Programs Shutter Around the World After Trump Pauses Foreign Aid

Lifesaving treatment and prevention programs for tuberculosis, malaria, H.I.V. and other diseases cannot access funds to continue work.

nytimes.com

The ASTMH has written an open Letter to Secretary of State, Marco Rubio, calling on America to sustain its leadership in global health security. www.astmh.org/blog/january... A concerted effort is needed to fight infectious diseases, including emerging diseases that affect the entire world.

Please read this important article from the New York Times by @stephanienolen.bsky.social . The shut down of Programs on HIV, TB and malaria for 90 days and the attack on the agenda of USAID is a very sad day for people who benefit from and care about global health initiatives.

Health Programs Shutter Around the World After Trump Pauses Foreign Aid (Gift Article)

Lifesaving treatment and prevention programs for tuberculosis, malaria, H.I.V. and other diseases cannot access funds to continue work.

nytimes.com

Stephanie Nolen@stephanienolen.bsky.social · 2y ago

I hated having to write this, but I'm grateful to the many people who risked their ability to do critically important work they love, by talking to me. (And I will continue to cover it, so if you want to talk to me, DM for my Signal.) www.nytimes.com/2025/02/01/h...

Excited to see our study published in @PLOSPathogens. Multi-stage activity & single oral dose killing of P. falciparum in vivo. Structural basis for improved potency and selectivity of this reaction-hijacking inhibitor are revealed. doi.org/10.1371/journal.ppat.1012429

2.2 billion #malaria cases and 12.7 million deaths have been averted since 2000 Find out more in the new WHO World Malaria Report 2024: 👉 bit.ly/4g31og6

The Biomolecular Horizons 2024 (BMH2024) Congress welcomed registrants from 44 countries to share new developments in biomolecular research, innovation and education. The Congress made possible by the work of some many amazing colleagues. Read the Report in the AB: lnkd.in/gbA7Hf_E Page 31-37.

An amazing cryoEM structure of the membrane-assembled lysosomal mTORC complex from the Hurley lab. @jimhurley.bsky.social www.biorxiv.org/content/10.1...

That's a wrap! With this awesome crew of go getters 🤩 We pulled off such a smooth huge conference! Thanks to all the #bmh2024 speakers, attendees and the never say die organisers. A privilege to work with you all! Let's never attempt this again 🫡

C/O the #adelaideproteingroup The Lorne Proteins Conference 2025 is coming up! Feb 9–13, 2025, it’s a must for protein science enthusiasts. 🇦🇺 Lorne, Victoria 💡 Connect with international experts, share your research, and explore the latest advancements. 📅 Register now: lorneproteins.org

Wonderful to hear inspirational speakers from @YouthriveVic at the breakfast at Parliament of Victoria, this morning. Thanks to Maree Edwards, Speaker of the Victorian Legislative Assembly, for hosting, and to Andrew McGuckian for organising the event.

Congratulations to Frances Separovic on being awarded a Docteur Honoris Causa from the University of Bordeaux. @FrancesBiophys

Congratulations to the team.

Paul McMillan@drpaulmcmillan.bsky.social · 2y ago

Delighted to update that our team at the Biological Optical Microscopy Platform has been awarded the University of Melbourne award for excellence in enabling research. Thanks to all of those that supported our application.

So lovely to join the celebrations for the 2024 L’Oréal-UNESCO For Women in Science celebration. Congratulations to the amazing award winners. Great to catch up with wonderful @Women in Science. @DrMistyJenkins

Congratulations @Kelly_Chibale on being elected to the United States National Academy of Medicine! https://nam.edu/national-academy-of-medicine-elects-100-new-members-2024/ Kelly discovered the first small molecule clinical candidate for any disease, researched on African soil by an...

Stories & Structures – New Connections. #BMH2024 featured an exhibition building on >60,000 yrs of Indigenous tradition in a collaboration with Microscopy Australia. Rich visual parallels between #Indigenous artworks and the microscopic world. Thanks to Jenny Whiting @Sydney_Uni

Excellent session on emerging pathogens! Lots to be scared about.

Everything you always wanted to know about Publishing but were too scared to ask. Great session.