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Lena Palaniyappan

@lenapl.bsky.social

Psychiatric researcher

48 Posts322 Follower616 Folgt
NPP-Digital Psychiatry and Neuroscience (DPN)@dpn-journal.bsky.social · last yr.

Check out this 🆕 paper form @lenapl.bsky.social et al showing that speech spectrograms can track negative symptom severity in schizophrenia www.nature.com/articles/s44...

Taking a look at your speech: identifying diagnostic status and negative symptoms of psychosis using convolutional neural networks - NPP—Digital Psychiatry and Neuroscience

Short snippets of everyday speech hold medical clues. Using computer vision techniques on sound pictures (“spectrograms”) from short speech fragments, researchers trained a neural network on recording...

nature.com

Communications Medicine@commsmed.nature.com · last yr.

🚨 NEW RESEARCH! ⚕️ 🩺 🧠 Elleuch et al. explore the association of grammatical challenges in people with Schizophrenia in a systematic review and meta-analysis of 45 studies. https://bit.ly/4kZnq66 @lenapl.bsky.social

Relationship between grammar and schizophrenia: a systematic review and meta-analysis - Communications Medicine

Elleuch et al, perform a systematic review and meta-analysis to evaluate the association between grammatical impairments and schizophrenia. Large effect size deficits in grammatical comprehension and production occur in this illness, highlighting the need for targeted interventions to address language use in people with psychotic disorders.

bit.ly

Lena Palaniyappan@lenapl.bsky.social · last yr.

One of the largest longitudinal study of computational speech and language features and psychosis from @stanglab.bsky.social Tang & colleagues! www.nature.com/articles/s44...

Automated speech and language markers of longitudinal changes in psychosis symptoms - NPP—Digital Psychiatry and Neuroscience

We used acoustic analysis and Natural Language Processing (NLP) to evaluate speech data from 66 individuals with psychosis, over time. The study identified specific language features that correlate wi...

nature.com

Neuropsychopharmacology@npp-journal.bsky.social · last yr.

#ThisWeekInNPP This study identified a prefrontal-limbic structural covariance network with ⬇️ gray matter volume specific to treatment-resistant schizophrenia, linked to serotonergic, glutamatergic, histaminergic, & opioid receptor distributions 🧠 www.nature.com/articles/s41...

Distinct structural deficits in treatment-resistant schizophrenia and their putative neurotransmitter basis: a source-based morphometry analysis - Neuropsychopharmacology

Neuropsychopharmacology - Distinct structural deficits in treatment-resistant schizophrenia and their putative neurotransmitter basis: a source-based morphometry analysis

nature.com

Lena Palaniyappan@lenapl.bsky.social · last yr.

www.nature.com/articles/s41... People with schizophrenia that is resistant to treatment may have specific prefrontal-limbic brain deficits linked to non-dopaminergic neurotransmitter systems—highlighting the need for therapies beyond antipsychotics. #schizophrenia #neuroscience #mentalhealth

Distinct structural deficits in treatment-resistant schizophrenia and their putative neurotransmitter basis: a source-based morphometry analysis - Neuropsychopharmacology

Neuropsychopharmacology - Distinct structural deficits in treatment-resistant schizophrenia and their putative neurotransmitter basis: a source-based morphometry analysis

nature.com

Timothy Caulfield@caulfieldtim.bsky.social · last yr.

Very, very obviously we need to emphasize science-informed preventative strategies. Public health experts – myself included – have focused on this for decades! But phrase "root causes" long ago morphed into a red flag for bunk. 🚩 news.immunologic.org/p/real-root-... @drandrealove.bsky.social‬👇

Real root cause medicine is based on science, not wellness disinformation.

RFK Jr, Marty Makary, and MAHA allies are lying to you. Biomedical research is BASED ON identifying and treating underlying causes of illness.

news.immunologic.org

CRBLM@crblm.bsky.social · last yr.

Congratulations to @lenapl.bsky.social, @sylvainbaillet.bsky.social and the whole team on the boost from the @wellcometrust.bsky.social for the DIALOG initiative douglas.research.mcgill.ca/news/underst...

Understanding Psychiatric Disorders Through Language: $9.8M from The Wellcome Trust for DIALOG Initiative - The Douglas Research Centre

Montreal, April 23, 2025   The Douglas Mental Health University Institute is proud to announce that the Wellcome Trust has awarded $9.8 million to Dr. Lena Palaniyappan in support of ... Read more

douglas.research.mcgill.ca

Lena Palaniyappan@lenapl.bsky.social · last yr.

We show cannabis use disorder is associated with higher midbrain neuromelanin, where such an increase is associated with #psychosis severity. The higher the use, the greater the putative dopamine turnover. Led by Jessica Ahrens @healthsciences.mcgill.ca IPN jamanetwork.com/journals/jam...

Convergence of Cannabis and Psychosis on the Dopamine System

This cohort study investigates the association between cannabis and the midbrain dopamine pathway involved in psychosis.

jamanetwork.com

Lena Palaniyappan@lenapl.bsky.social · last yr.

When we are depressed, we not only have negative thoughts but also experience a muddled, disorganized thinking process. We propose some steps to make progress in understanding and reducing the burden of disorganization in #Depression link.springer.com/article/10.1...

Disorganisation and depression: a re-examination of how we think and speak when depressed - European Archives of Psychiatry and Clinical Neuroscience

Disorganised thinking in severe mental illness seriously cripples social functions. Historically, the study of disorganisation has primarily concentrated on schizophrenia, utilizing tools designed to ...

link.springer.com

Lena Palaniyappan@lenapl.bsky.social · last yr.

www.sciencedirect.com/science/arti... We see a prominent excess of first-person pronouns in #schizophrenia, with no excessive inter-individual variability. While not a direct comparison, this effect (d=0.89) is >> than striatal dopamine excess or prefrontal glutamate reduction reported to date.

Speaking of yourself: A meta-analysis of 80 years of research on pronoun use in schizophrenia

People with schizophrenia experience significant language disturbances that profoundly affect their everyday social interactions. Given its relevance …

sciencedirect.com

Lena Palaniyappan@lenapl.bsky.social · last yr.

#Pubmed is down again. #NIH It has never been down like this for more than 20 years that I have been using it. They are likely cleaning up all mentions of gender, race, diversity, ethnicity, humanity, etc. I am confident they will not touch the keyword - 'stupidity'.