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Lewis Holt

@lewisholt.bsky.social

Post-doctoral scientist Laboratory of Behavioural Genetics EPFL, Lausanne 🏴󠁧󠁢󠁷󠁬󠁳󠁿🇪🇺🇨🇭

37 Posts528 Follower232 Folgt
Melissa Cooper, PhD@melcooperphd.bsky.social · 4mo ago

Astrocytes do so much more than any of us thought - they even communicate among specific brain regions across hemispheres! The journey to this paper spanned nearly a decade, but I'm most excited to see what everyone else does with the tools we've built. There's so much for all of us to explore!

Astrocytes connect specific brain regions through plastic networks - Nature

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

nature.com

Ciarán Murphy-Royal@murphyroyallab.org · 4mo ago

Incredibly proud of this paper led by @ossamaghenissa.bsky.social and @mathiasgua.bsky.social titled Basolateral 'Amygdala Astrocytes Encode Anxiety States'. www.cell.com/neuron/fullt... 🧵 below

Basolateral amygdala astrocytes encode anxiety states

Ghenissa et al. provide evidence that basolateral amygdala astrocytes reliably encode anxiety states. Using simultaneous in vivo calcium recordings across an array of behavioral tasks, combined with g...

cell.com

Lewis Holt@lewisholt.bsky.social · 6mo ago

🚨Great science in a stunning location!🚨 (Can confirm both are true)

Global Stress and Resilience Network (GSRNet)@gsrnet.bsky.social · 6mo ago

📌 The 2027 Global Stress & Resilience Meeting is now confirmed! 🗓️ Feb 3–5, 2027 📍 EPFL, Lausanne (Switzerland) Calls will be launched soon for: • Proposals for the scientific program • The GSRNet Breakthrough Award • The Junior Investigators Awards Stay tuned for more details! #GSRNet2027

Ciarán Murphy-Royal@murphyroyallab.org · 7mo ago

Delighted to share our first preprint of the year! A project that we're all really proud of in the lab led by @ossamaghenissa.bsky.social with @mathiasgua.bsky.social in which we set out to test the role of basolateral amygdala astrocytes in anxiety behaviour. www.biorxiv.org/content/10.6...

Astrocytic Encoding of Threat in the Basolateral Amygdala

The basolateral amygdala (BLA) has long been implicated in threat detection and the generation of anxiety states. While previous experiments have demonstrated the important role of BLA principal neuro...

biorxiv.org

Lewis Holt@lewisholt.bsky.social · last yr.

Absolutely thrilled to share the first half of my PhD work! Super proud to see it finally out! www.nature.com/articles/s41... Thread below for a quick (10 point) recap of what we found! 🧵🧪🧠

A divergent astrocytic response to stress alters activity patterns via distinct mechanisms in male and female mice - Nature Communications

Early-life stress has lifelong impacts on neuronal function and behavior. Here, the authors show that astrocytic glucocorticoid receptor signaling drives stress-induced neuronal and behavioral change ...

nature.com

Alex Chen@alexbchen.bsky.social · last yr.

Excited to share that the astrocyte-centered half of my thesis work is now out @science.org ! With @mishaahrens.bsky.social and @marcduque.bsky.social science.org/doi/10.1126/... 1/8

Norepinephrine changes behavioral state through astroglial purinergic signaling

Both neurons and glia communicate through diffusible neuromodulators; however, how neuron-glial interactions in such neuromodulatory networks influence circuit computation and behavior is unclear. Dur...

science.org

Papouin Lab @ WashU@papouinlab.bsky.social · last yr.

Thought this would be a nice way to enter the bsky community👇Delighted for Katie (now in Chris Dulla's lab at Tufts). Thank you to our collaborators, to the reviewers and to Cagla Eroglu for the highlight! www.science.org/doi/10.1126/...

Norepinephrine signals through astrocytes to modulate synapses

Locus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level...

science.org

Lewis Holt@lewisholt.bsky.social · last yr.

Super cool that these are finally out!! Check out some of the protocols we've been using to investigate the role of astrocytes in stress!

Ciarán Murphy-Royal@murphyroyallab.org · last yr.

Very happy to share several common protocols used in our lab for the second edition of the book "Astrocytes: Methods and Protocols" @lewisholt.bsky.social @astroantho.bsky.social Thanks @dibenedetto-lab.bsky.social for being a very patient editor! link.springer.com/book/10.1007...

Ciarán Murphy-Royal@murphyroyallab.org · last yr.

Version of Record of our work at @elife.bsky.social has been published! Super proud of this one after all the hard work of the lab seeing it to the end. Make sure to click through figure supplements as there is so much good stuff in there - sex differences, etc. elifesciences.org/articles/99988

Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation

Amygdala astrocytes play a critical role in mediating the effects of stress during infancy on neuronal excitability, synaptic plasticity, and memory.

elifesciences.org

Ciarán Murphy-Royal@murphyroyallab.org · 2y ago

Delighted to share an update to our preprint, reviewed at @elife.bsky.social, and now sent back for re-review. Colossal work by the team and driven home by @mathiasgua.bsky.social Quick 🧵 of what's new - www.biorxiv.org/content/10.1...

Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation

Early-life stress can have lifelong consequences, enhancing stress susceptibility and resulting in behavioural and cognitive deficits. While the effects of early-life stress on neuronal function have ...

biorxiv.org