Lisa Gourdon-Grünewaldt

@lggchem.eu

Postdoc DNA mimics 🧫🧬 @akhuc.bsky.social at LMU | PhD photodynamic therapy 🧪💡 @gassergroup.bsky.social & @cariouk.bsky.social at PSL | Alumna Chimie ENS Ulm | 🌈🚲🛠️ Co-founder of @fychembio.fr 🌍 lggchem.eu #ChemBio ORCID: 0000-0003-0932-7838

I was delighted to present my postdoctoral work in the Chang Lab on the beautiful campus of Princeton University, USA. 🌳 Thank you everyone for the warm welcome and the fruitful discussions, also on bioinorganic chemistry projects. Many thanks to Chris Chang for this opportunity!

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I am very happy to have visited the Biotechnology and Cell Signalling laboratory in Strasbourg! Many thanks to Vladimir Torbeev for inviting me to present my research about foldamers and transcription factors. It was a pleasure meeting researchers working on a very wide variety of topics. 🧬

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Join this event in Berlin (Oct 23–24) for the 25th anniversary of ChemPhysChem & ChemBioChem!🧪 Students: register for just 75 EUR (DM us to get the discount code) 😀 Speakers include Nobel Laureate Stefan Hell, Theresa Carlomagno, Gilles Gasser, Lynn Kamerlin, Kathrin Lang & more! 🔗 cbc-cpc2025.org

Fantastic week at #ChemBioParis2025! Incredible lineup of international speakers showing the diversity and creativity in chemical biology 🧬🧪 and many participants from all around the world! 🌍 Great science, great community :D Huge thanks to everyone involved in the organisation!

You can check out this paper to know how we achieved automated synthesis of aromatic oligoamide foldamers with a very wide variety of biogenic side chains! 🤖 pubs.acs.org/doi/10.1021/...

Development of Aromatic Foldamer Building Blocks Bearing Multiple Biogenic Side Chains

Aromatic oligoamides, with their intrinsic rigidity and well-defined conformations, are recognized for their potential in medical applications. Similar structures are present in several naturally occurring antibiotics and have been explored for their ability to bind to various proteins and B-DNA (canonical right-handed DNA helix). This study introduces a synthetic approach to produce quinoline amino acid monomers bearing diversified side chain combinations in positions 4, 5, and 6 of the quinoline ring, designed to enhance the side chain density on helical foldamers. By increasing the number of side chains on each monomer, we aim to mimic the dense side chain presentation of α-peptides, thus improving the potential for protein surface recognition. This synthetic strategy involves efficient functionalization through cross-coupling reactions, enabling the installation of diverse side chains at strategic positions on the quinoline ring. The process has been optimized for automated solid-phase synthesis, successfully producing a 20-unit oligoamide with good purity. This foldamer, featuring multiple cationic, anionic, polar, and hydrophobic side chains, demonstrates the potential for molecular recognition in drug discovery and therapeutic applications. The methodology described here represents a significant advancement in the construction of aromatic oligoamide foldamers, providing a robust platform for further exploration of biological systems.

pubs.acs.org