The paper “solves this long-standing problem of how you learn about landmarks in the world,” - @lgiocomo.bsky.social, Stanford University. #neuroskyence By @natmesanash.bsky.social www.thetransmitter.org/learning-and...
Unique learning mechanism drives navigation in fruit flies
The neuromodulator octopamine, the insect counterpart to norepinephrine, helps flies get their bearings in an unfamiliar environment.
thetransmitter.org
Beautiful early morning run yesterday from Chevy Chase to DC! Now time for science!
New paper! Congrats to @markplitt.bsky.social, Konstantin and team! The brain’s spatial map isn’t static but for hippocampus CA1 maps to change with experience, they need postsynaptic membrane fusion. A new link between synaptic machinery and flexible coding! www.sciencedirect.com/science/arti...
Hippocampal place code plasticity in CA1 requires postsynaptic membrane fusion
Rapid delivery of glutamate receptors to the postsynaptic membrane via vesicle fusion is a central component of synaptic plasticity. However, it is un…
sciencedirect.com
Great papers in spatial neuro this week. Csicsvari's group: hippocampal place fields stabilise during learning while mPFC stays flexible. Giocomo's lab: CA1-subiculum topography actively shapes boundary coding & corner cells. doi.org/10.64898/2026.03.27.714523 doi.org/10.64898/2026.03.24.714092
Congrats @emilyaeryjones.bsky.social and team! The brain doesn’t just map where you are, it maps where it matters. Great thread below!
Emily A. Aery Jones@emilyaeryjones.bsky.social · 4mo agoMy main postdoc work is now published: www.nature.com/articles/s41...! We (myself, Isabel Low, Frances Cho, and @lgiocomo.bsky.social) discovered task-relevant remote representations in entorhinal cortex independent of CA1. #paperthread below! 1/13
New preprint! Circuit wiring isn’t just anatomy, it shapes computation. Disrupting CA1→subiculum topography reorganizes spatial coding and destabilizes network dynamics. Great collab led by Yanjun Sun, & with D Pederick, X Xu & L Lou! www.biorxiv.org/content/10.6...
biorxiv.org
Spatial navigation in preclinical Alzheimer's disease: A review New review from @antoinegc.bsky.social and @antoinecoutrot.bsky.social labs, on which I am a co-author, and first author is the amazing Syrine Salouhou arxiv.org/abs/2603.23082
Fun afternoon with the lab learning how to make homemade pasta!
Really enjoyed writing up this article with Lavonna Mark for @cp-trendscognsci.bsky.social on how internal states - like attention, arousal, or goals - can reshape our brain's map of space, helping the brain adapt navigation to what matters most. www.sciencedirect.com/science/arti...
State-dependent spatial maps for navigation
Internal behavioral states influence many brain circuits, with well-known effects in sensory areas. Less is known about how these states shape downstr…
sciencedirect.com
Anyone else running into NPX 2.0 supply issues? Heard there’s a 90 pause on accepting new orders 🫣
Holiday brunch with the lab! Grateful for this community of creative and thoughtful scientists!
I often tell my students that graduate school is a marathon—pace yourself, refuel consistently, and build a strong support team.
Calling all rising juniors & seniors: Interested in biological or biomedical research? Applications for our ’26 Summer Undergraduate Research Experience Program are now open! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows
Summer Undergraduate Research Experience | HHMI
The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.
bit.ly
The Sosa Lab is going to #SfN25 and actively recruiting ✨postdocs✨ with systems neuroscience experience! We study both fundamental memory processes and how memory changes during pregnancy and postpartum. If you are interested in meeting at SfN, please email me! www.sosaneurolab.com/join/postdoc...
Sosa Lab - Postdoctoral Researchers
We are seeking postdocs to start in 2026!
sosaneurolab.com
Congrats to lead authors @alexattinger.bsky.social and Tony Drinnenberg and all our amazing collaborators! Check out the thread below for new work from the lab on plasticity, cortex and spatial representations for navigation!
Alex@alexattinger.bsky.social · 10mo agoHow does the brain balance learning new things without overwriting what it already knows? Our new paper tackles this long-standing stability–plasticity dilemma during active navigation. With Tony Drinnenberg from the Deisseroth Lab (@deisseroth.bsky.social) doi.org/10.1101/2025...
Excited to announce that my first postdoc paper is now online! Links: www.nature.com/articles/s41... rdcu.be/eAcN7 In it, we examine the perennial question: what changes in the brain when learning a new motor skill? Read more below to find out 👇
Differential kinematic coding in sensorimotor striatum across behavioral domains reflects different contributions to movement - Nature Neuroscience
Hardcastle and Marshall et al. show that striatal function is domain specific, required for task-related but not spontaneously expressed movements. This functional distinction is reflected in starkly ...
nature.com
It's officially published!! In my main postdoc work with @markplitt.bsky.social and @lgiocomo.bsky.social, we found that the hippocampus simultaneously encodes an animal's spatial position and its experience relative to reward in parallel population codes. 🧵 www.nature.com/articles/s41...
A flexible hippocampal population code for experience relative to reward - Nature Neuroscience
Sosa et al. find that hippocampal neural activity in mice encodes both environmental location and experience relative to rewards, spanning distances far from reward, through parallel and flexible popu...
nature.com
New paper from the lab officially out! Congratulations @marisosa.bsky.social - amazing work - and just before she sets off to UC Boulder to start her own lab!
@stanfordbrain.bsky.social · last yr.How does the brain map where rewards are found? Stanford researchers Lisa Giocomo and Mari Sosa found that mice form adaptable hippocampal maps that track reward locations, offering insight into how memory, dementia & addiction relate to place and reward. neuroscience.stanford.edu/news/locatio...
Please re-post and share! This is a great effort to improve communication of science benefits and discoveries
Nicole Rust@nicolecrust.bsky.social · last yr.Calling all science advocates!! Carlos Brody+ are creating a searchable database of tangible science benefits, and they need you. publicusaresearchbenefits.com They are asking for suggestions - from brief to lengthy. The database is state-searchable, so all 50 states. Please spread the word!
Calling all science advocates!! Carlos Brody+ are creating a searchable database of tangible science benefits, and they need you. publicusaresearchbenefits.com They are asking for suggestions - from brief to lengthy. The database is state-searchable, so all 50 states. Please spread the word!
Searchable database of tangible benefits that federally-funded research gave us.
A crowd-sourced site. Health and Well-being. National Security. Prosperity.
publicusaresearchbenefits.com
New lab alert!! Mari is an incredibly creative and awesome scientist - plus an amazing mentor! If you have the opportunity to join her lab - I can’t recommend it enough - can’t wait to see her get started ❤️
Mari Sosa@marisosa.bsky.social · last yr.Exciting news!! I’m joining the tenure-track faculty at University of Colorado Boulder this fall as an Assistant Professor of Psychology & Neuroscience! The Sosa Lab will study how memory is shaped by cognitive and physiological demands, including during pregnancy and the postpartum period. 🧵
Looking forward to a day of science at @CSHL! Started my day with a sunrise run - such a beautiful campus
Congratulations to Charlotte Herber on her beautiful thesis defense today! The MD world is very lucky to have you headed back to clinic soon but we will miss you! Excited to see where your future path takes you in research and medicine!
New from the lab!! 👉🏼 authors.elsevier.com/a/1kgT43BtfH... 📝 @cellpress.bsky.social We discovered that genetically-defined neuron types in the hippocampus form unique manifolds! Dual color imaging, chemogenetics and topological analysis all at once! With Juan Gallego @juangallego.bsky.social
Congratulations to John Wen on his thesis defense! Amazing to see what you've accomplished over your PhD and can't wait to see where your journey takes you!
We are looking for a research tech! Come join the team - apply here: hhmi.wd1.myworkdayjobs.com/en-US/Extern...
Research Technician- Giocomo Lab
Primary Work Address: Beckman Center, Stanford, CA, 94305-5323 Current HHMI Employees, click here to apply via your Workday account. We are currently looking for a scientifically curious Research Tech...
hhmi.wd1.myworkdayjobs.com
