Excited to share our Commentary in JCI. Exploring how SIRT2 regulates human beta cell proliferation www.jci.org/articles/vie... @jci.org

Journal of Clinical Investigation@jci.org · 10mo ago

SIRT2 puts the brakes on human beta cell proliferation: Therapeutic opportunities and next challenges: www.jci.org/articles/vie... Liora S. Katz @likatz.bsky.social, Donald K. Scott, & Andrew F. Stewart provide a Commentary on Katz et al.: www.jci.org/articles/vie...

NIH is the best investment there is. www.forbes.com/sites/michae...

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report

National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

forbes.com

A molecular glue’ compound led to potent ChREBPα/14-3-3 PPI stabilization, retained ChREBPα in the cytoplasm, and efficiently protected β-cells from glucolipotoxicity while maintaining β-cell identity. @naturecomms.bsky.social www.nature.com/articles/s41...

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity - Nature Communications

Targeting transcription factors with small molecules remains a significant challenge in drug discovery. Here, the authors present a structure-based approach to stabilize ChREBPα/14-3-3 interactions, s...

nature.com

Excited to share our work in @naturecomms.bsky.social We shows that molecular glues of the ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. This could lead to new treatments for Diabetes by preserving beta cell function. www.nature.com/articles/s41... #DiabetesResearch #BetaCells

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity - Nature Communications

Targeting transcription factors with small molecules remains a significant challenge in drug discovery. Here, the authors present a structure-based approach to stabilize ChREBPα/14-3-3 interactions, s...

nature.com

✨NYC Stand Up for Science Rally: March 7 (12-3pm)✨ This event is a call to protect publicly funded science from political interference and to reaffirm that diversity, equity, inclusion, and access are essential to scientific progress. @standupforscience.bsky.social (permit pending for location)

Making America great means supporting research that saves lives, improves health, and drives new technology. Freezing NIH funding hurts all of us. Let’s tell our leaders to INCREASE funding for the NIH and keep America at the forefront of science and innovation!

Ilan Schwartz@germhuntermd.bsky.social · 2y ago

Scientific advancements aside, this is economically irresponsible Every $1 spent by NIH generates $2.46 For example, in 2023, $47B in NIH spending generated ~$93B Halting NIH spending will LOSE the US a lot of money (and talent)

Happy to be a part of this amazing interdiciplinary reseach group!

Women in TPD & Induced Proximity@womenintpd.bsky.social · 2y ago

New work led by Liora Katz at Mt. Sinai along with colleagues of a non-degrading molecular glue between a TF (ChREBP) and a 14-3-3 protein which effectively traps the TF in the nucleus, thereby preventing activation of its target genes in the nucleus. Congratulations! www.biorxiv.org/content/10.1...

New work led by Liora Katz at Mt. Sinai along with colleagues of a non-degrading molecular glue between a TF (ChREBP) and a 14-3-3 protein which effectively traps the TF in the nucleus, thereby preventing activation of its target genes in the nucleus. Congratulations! www.biorxiv.org/content/10.1...

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity

The Carbohydrate Response Element Binding Protein (ChREBP) is a glucose-responsive transcription factor (TF) with two major splice isoforms (α and β). In chronic hyperglycemia and glucolipotoxicity, C...

biorxiv.org