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Lingchong You

@lingchongyou.bsky.social

92 Posts115 Follower112 Folgt
Lingchong You@lingchongyou.bsky.social · 2w ago

1/ Let’s face it: we synthetic biologists are control freaks. We want every component to do exactly what we intend. Our new @natcomms.nature.com paper asks what happens if we stop fighting biological “messiness” and learn to live with it. @dukeubme.bsky.social www.nature.com/articles/s41...

Engineering microbial consortia for distributed signal processing - Nature Communications

Multiplexed biosensing is often limited by crosstalk between sensors. Here, authors distribute sensing across microbial communities and use timer-resolved modelling and machine learning to infer multi...

nature.com

Jerónimo Rodríguez-Beltrán@jerorb.bsky.social · last yr.

🚨🚨New paper out in @natcomms.nature.com!! Come for the first large-scale analysis of plasmid copy number across species, stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬 👉 www.nature.com/articles/s41...

Universal rules govern plasmid copy number - Nature Communications

Plasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy number of thousands of diverse b...

nature.com

Lingchong You@lingchongyou.bsky.social · last yr.

1/ What's the worst enemy of a plasmid? Another plasmid! Our new study demonstrates synthetic plasmids engineered as "Trojan horses" to eliminate plasmids encoding antibiotic resistance. @dukeubme.bsky.social www.science.org/doi/10.1126/...

A predatory gene drive for targeted control of self-transmissible plasmids

A biological “denial-of-spread” (DoS) strategy leverages retrotransfer to eliminate target plasmids in microbial communities.

science.org

Lingchong You@lingchongyou.bsky.social · last yr.

1/n. Excited to share our newest paper just published in @natchemeng.bsky.social , exploring how biomolecular condensates can be used to control metabolic pathways in cells. www.nature.com/articles/s44...

Principles of metabolic pathway control by biomolecular condensates in cells - Nature Chemical Engineering

Biomolecular condensates have emerged as a promising strategy to control metabolic reactions in living cells. Here the authors use mathematical modeling to uncover the key physical parameters that gov...

nature.com

Nature Chemical Engineering@natchemeng.nature.com · last yr.

🚨 Online Now! An Article from Lingchong You and co-workers analyzes the conditions under which biomolecular condensates can amplify the yield or selectivity of diverse metabolic pathways. @lingchongyou.bsky.social www.nature.com/articles/s44... Link ($) Free PDF: rdcu.be/edskn #ChemSky #ChemBio

Marine C. Cambon@marccamb.bsky.social · last yr.

Thank you @evolvedbiofilm.bsky.social for such a great organisation and everyone for the fantastic discussions. I even managed to visit Amsterdam Microbe Museum before catching my train! Looking forward to hosting you, @sofiaifgomes.bsky.social and Xinming in Birmingham !

Petri dishes with microorganisms from Amsterdam Microbe Museum Artis Micropia
Ákos T Kovács@evolvedbiofilm.bsky.social · last yr.

Thank you, @jamesemcdonald.bsky.social & @marccamb.bsky.social for your visit in Leiden, discussing cool ideas around plant-microbe interactions, exploring #leidenbotanicalgarden 👋 see you again soon!

Lingchong You@lingchongyou.bsky.social · last yr.

1/n. Excited to share our latest work published in @naturecomms.bsky.social , exploring how antibiotics reshape microbial communities. We reveal two critical factors driving the complex restructuring outcomes observed after antibiotic exposure. @dukeubme.bsky.social doi.org/10.1038/s414...

Antibiotic-mediated microbial community restructuring is dictated by variability in antibiotic-induced lysis rates and population interactions - Nature Communications

Antibiotic treatment usually selects for fast-growing bacterial cells, but that is not always the case. Here, Kim et al. show that antibiotic-induced changes in bacterial communities depend on variabi...

doi.org

Michael Brockhurst@brockhurstlab.bsky.social · 2y ago

Out now: enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/... Fun collaboration with @biotechdixon.bsky.social and great work by PhD Alejandro! I guess we really do biotech now?!

Genetic Bioaugmentation‐Mediated Bioremediation of Terephthalate in Soil Microcosms Using an Engineered Environmental Plasmid

Synthetic operon-encoding genes for the uptake and catabolism of xenobiotic terephthalate, inserted into self-mobilisable environmental plasmid. Delivery of the plasmid-encoded trait via horizon gene...

enviromicro-journals.onlinelibrary.wiley.com

Michael Brockhurst@brockhurstlab.bsky.social · 2y ago

Dipping a toe into synthetic biology… our favourite plasmid (pQBR57, if you’re asking) is made into a bioremediation-gene-spreading-machine to help clean-up plastic manufacturing. With Neil Dixon + led by Alejandro Marquiegui www.biorxiv.org/content/10.1...

Gene Chong@chongg.bsky.social · 2y ago

A new paper from Lingchong You's group develops a cool amplification circuit that expands the dynamic range of plasmid transfer #ChemBio #synbio #microsky www.nature.com/articles/s41...

Population-level amplification of gene regulation by programmable gene transfer - Nature Chemical Biology

Gene regulation in engineered microbial populations is often tuned at individual cell levels. Now, a population-wide amplification system has been devised that expands the dynamic range of plasmid tra...

nature.com

Lingchong You@lingchongyou.bsky.social · 2y ago

1/ Hello BlueSky world -- my first post is about a new study from the lab, just published in @nchembio.bsky.social. We demonstrate how population-level gene regulation can be dynamically controlled and amplified using programmable gene transfer. Link to paper: doi.org/10.1038/s415...

Population-level amplification of gene regulation by programmable gene transfer - Nature Chemical Biology

Gene regulation in engineered microbial populations is often tuned at individual cell levels. Now, a population-wide amplification system has been devised that expands the dynamic range of plasmid tra...

doi.org