Expanding the repertoire of chemically induced covalent neoantigens - Nature Chemical Biology

Small molecules can covalently modify proteins to generate hapten-modified peptides, triggering T cell-mediated immune responses. Now a chemoproteomic platform enables the discovery of covalent neoant...

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Restoring intracellular homeostasis disrupted by synthetic nanoassemblies - Nature Chemical Biology

Cells have evolved defense pathways to maintain homeostasis against external perturbations, but not against new-to-nature nanomaterials, which can irreversibly accumulate and induce cell stress. Now, ...

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Designing fiber–gut microbiome interactions with active learning - Nature Chemical Biology

Dietary fibers are a primary energy source for gut bacteria and shape the composition and function of the microbiome. Now, an active learning approach integrating explainable machine learning, Bayesia...

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Protein stability is determined by single-site bias rather than pairwise covariance - Nature Chemical Biology

Sequence biases at individual positions can be used to design more stable protein variants, while correlation between pairs of residues has also been shown to be important for specifying protein struc...

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Tumor immune cell targeting chimeras reprogram tumor-associated macrophages - Nature Chemical Biology

Tumor-associated macrophages (TAMs) predominantly adopt an M2-like pro-tumor phenotype, promoting anti-inflammatory signaling and cancer cell metastasis. Now, tumor immune cell targeting chimeras enab...

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Munc13-4–STX7 inhibitors impair endosomal TLR activation and systemic inflammation - Nature Chemical Biology

Endosomal Toll-like receptors (TLRs) are central to the innate immune response but their overactivation can cause systemic inflammation and disease. Now, new small molecules targeting the interaction ...

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Structures of ALG3/9/12 reveal the assembly logic of the N-glycan oligomannose core - Nature Chemical Biology

Three endoplasmic reticulum luminal mannosyltransferases ALG3, ALG9 and ALG12 catalyze the synthesis of the branched mannose core in N-glycans in four distinct steps. Now, cryo-electron microscopy str...

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Modular engineering of thermoresponsive allosteric proteins - Nature Chemical Biology

Thermogenetics enables spatiotemporal control of protein activity using temperature. Now, engineering of a compact, insertable thermoresponsive protein module diversifies the classes of proteins amena...

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Uncovering bacterial pseudaminylation with pan-specific antibody tools - Nature Chemical Biology

Pseudaminic acids (Pse) are a family of carbohydrates found within bacterial lipopolysaccharides, capsular polysaccharides and glycoproteins. Now, monoclonal antibodies have been developed that recogn...

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Functional analysis of O-GlcNAcylation by networking of OGT interactors and substrates - Nature Chemical Biology

Functional studies of O-GlcNAcylation have often focused on individual modifications. Now, a systems-level approach has identified simultaneous O-GlcNAcylation events that coordinate cellular activiti...

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Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells - Nature Chemical Biology

The xylosyltransferase isoenzymes XT1 and XT2 catalyze the first glycosylation step in the biosynthesis of proteoglycans. Now, bump-and-hole engineering of XT1 and XT2 enables substrate profiling and ...

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Associate or Senior Editor, Nature Chemical Biology

Job Title: Associate or Senior Editor, Nature Chemical Biology Organization: Nature Portfolio Location: New York, Washington DC, Jersey City, Beijing or Shanghai – Hybrid working Model Closing date: D...

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Temporal photoproximity labeling of ligand-activated EGFR neighborhoods using MultiMap - Nature Chemical Biology

A multiscale photoproximity labeling proteomics workflow captures dynamic neighborhoods of extracellular and intracellular epidermal growth factor (EGF) receptor interactomes during early, middle and ...

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IDR-induced CAR condensation improves the cytotoxicity of CAR-Ts against low-antigen cancers - Nature Chemical Biology

Low-antigen-expressing cancers are a challenge to existing chimeric antigen receptor (CAR)-T cell-based therapies. Now, it has been shown that fusion of intrinsically disordered regions to CARs induces CAR condensation and enhances antigen sensitivity and killing activity of CAR-T cells.

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Molecular basis for the regulation of membrane proteins through preferential lipid solvation - Nature Chemical Biology

Static protein structures can capture the association of lipids, but it is unclear whether the association is due to lipids acting as long-lived ligands or the solvation of preferred lipids around the protein. A computational-experimental framework has now shown that for the protein CLC-ec1, it is the change in lipid solvation energies that drives dimerization, with preferred lipids around the protein modulating this driving force.

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Engineering synthetic agonists for targeted activation of Notch signaling - Nature Chemical Biology

The development of soluble Notch agonists is a challenge because of the mechanical forces needed to activate Notch receptors. Here, bispecific Notch agonist proteins were designed that ‘pull’ on and activate Notch receptors in the presence of desired biomarkers.

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Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology

An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...

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Real-time visualization of STAT activation in live cells using genetically encoded biosensors - Nature Chemical Biology

The signal transducer and activator of transcription (STAT) family proteins are attractive drug targets but tools to monitor their activation are lacking. Now, STAT biosensors have been developed for ...

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An unbiased proteomic platform for ATE1-based arginylation profiling - Nature Chemical Biology

Arginylation is a post-translational modification that is difficult to distinguish from arginine residues using mass spectrometry. Now a method has been developed to profile protein arginylation ex vi...

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Structure-guided phage display discovery of antibodies for (S)Tn-glycans in protein context - Nature Chemical Biology

Structural studies of certain Tn and STn antigen-targeting antibodies reveal that their VH and VL domains recognize the glycan antigen and the adjacent peptide region, respectively, enabling a VH doma...

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Mechanism of capsaicin entry into buried vanilloid sites in TRPV1 - Nature Chemical Biology

The primary entry route of vanilloid ligands to the vanilloid-binding site in transient receptor potential vanilloid 1 (TRPV1) is found to be a distinct and targetable hydrophobic pathway at the TRPV1...

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Protein β-O-glucosylation by Legionella LtpM through short consensus sequons G-T/S and S-G - Nature Chemical Biology

Legionella effector LtpM is found to recognize short two-residue sequons, enabling site-specific O-glucosylation with minimal perturbations to a target protein, and is used to show that O-glucose can ...

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Molecular recording of cellular protein kinase activity with chemical labeling - Nature Chemical Biology

Molecular recorders based on kinase activity-dependent protein labeling track specific kinase activities to understand their link to cellular phenotypes in heterogeneous cell populations and in vivo.

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