Support my DGR fundraising journey! I will be riding my Indian Chieftain with hundreds of others bikers to rise awarness on men's mental health and prostate cancer! gentlemansride.com/fundraiser/P...

Pietro Berico | The Distinguished Gentleman's Ride

Support Pietro Berico's fundraising campaign. They've raised $52 so far!

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New preprint from the Hernando lab! www.biorxiv.org/content/10.6... Combining 3D genome profiling and high resolution imaging we demonstrate how chromatin architecture cooperate with mechanical confinement in conferring melanoma mesenchymal cells high migratory capacities.

Sharing our latest work from the Hernando lab in @aacrjournals.bsky.social Cancer Discovery. Thanks to the collaborative effort between #nyulangone and internation institutions we show how melanoma cells can evade the immune system by activating the transcription factor HOXD13.

Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com)‬ paper, Miranda Hunter (@mrndhntr.bsky.social‬) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2

Another great preprint out from the Hernando lab, lead by Maria Gomez and Allie Kartz. Did you know that melanoma brain metastasis upregulate the carnosine dipeptidase CNDP1 through MITF to prevent intracellular copper accumulation? www.biorxiv.org/content/10.1...

The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis

Brain metastatic cells undergo metabolic adaptations, such as increased reliance on oxidative phosphorylation. Integrating proteomic and transcriptomic profiling of patient samples revealed a consiste...

biorxiv.org

Finally out our work showing the specific inhibition of melanoma-lineage identity genes using a new generation of ecteinascidin. Kudos to the only one Frédéric Coin and collaborators! www.nature.com/articles/s41...

Pan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity - Nature Communications

Super-enhancers (SEs) drive specific gene expression programmes underlying different cancer cell states offering opportunities for therapeutic targeting. Here, the authors suggest targeting SE-depende...

nature.com

Excited to share a major breakthrough from the lab! D&D-seq is a new technology that bridges a key gap in single-cell multi-omics/genomics : the ability to map DNA:Protein interactions (e.g., TFs or chromatin remodellers). Led by Ivan Raimondi, Wei-Yu Chi and Sang-Ho Yoon

@ivanraimondi.bsky.social · 2y ago

🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting. Check it out here: biorxiv.org/content/10.1... #Genomics #Epigenetics

If you are looking for an holiday read, check out our new story on how HOXD13 promotes melanoma growth! Others stories are coming soon thanks to my mentor and partner in crime Eva Hernando at @nyulangonepccsm.bsky.social. www.biorxiv.org/content/10.1...

A targetable developmental program co-regulates angiogenesis and immune evasion

Ultraviolet (UV)-induced DNA mutations produce genetic drivers of cutaneous melanoma initiation and numerous neoantigens that can trigger anti-tumor immune responses in the host. Consequently, melanom...

biorxiv.org

We just posted a preprint about a death mechanism that we find truly surprising. When you turn off transcription, cells die (duh!)... but did you know this happens due to loss of Pol II itself, not loss of Pol II activity!?! preprint here and a thread (1/n): www.biorxiv.org/content/10.1... 🧪

Pol II degradation activates cell death independently from the loss of transcription

Pol II-mediated transcription is essential for eukaryotic life. While loss of transcription is thought to be universally lethal, the associated mechanisms promoting cell death are not yet known. Here,...

biorxiv.org

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...

ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements - Nature Genetics

ChIP-DIP (ChIP done in parallel) is a highly multiplex assay for protein–DNA binding, scalable to hundreds of proteins including modified histones, chromatin regulators and transcription factors, offe...

nature.com

Leonid Mirny and I wrote this for all interested in chromosomes: "The chromosome folding problem and how cells solve it" www.cell.com/action/showP...