💫PUBLISHED @natgenet.nature.com 📰Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation. By @masashi-nomura.bsky.social, @landau.bsky.social, Mario L. Suvà and colleagues. ⬇️ www.nature.com/articles/s41...

Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation - Nature Genetics

The authors use single-cell multi-omics to interrogate longitudinal samples of isocitrate dehydrogenase mutant gliomas. Their analyses couple progression and hypomethylation with changes in differenti...

nature.com

A new study using laboratory technology reveals the inner workings of how a type of brain tumor progresses toward greater malignancy. NYGC Core Faculty @landau.bsky.social led this research with colleagues at Harvard Medical School and Mass General Brigham. Article: www.nygenome.org/news-events/...

Cancer Evolution Study Reveals Biology of Glioma Progression - July 10, 2026

Read about Cancer Evolution Study Reveals Biology of Glioma Progression at the New York Genome Center on July 10, 2026

nygenome.org

New results with tree reconstruction of glioma progression. Phylodynamics applied to primary patient samples allow to define how progression is linked to changes in differentiation hierarchies. We ❤️ trees!

Masashi Nomura@masashi-nomura.bsky.social · last mo.

1/12 Excited to share that our new paper on IDH-mutant glioma (IDH-G) is now out in Nature Genetics! This work was a fantastic collaborativ effort of laboratories of @suvalab.bsky.social and @landau.bsky.social, co-lead by Ramya Raviram and Joshua S. Schiffman. www.nature.com/articles/s41...

Congratulations to @landau.bsky.social, New York Genome Center Core Faculty Member, a 2026 Recipient of a Lotus Award from the Pershing Square Foundation www.nygenome.org/news-events/...

New York Genome Center Core Faculty Member, Dr. Dan Landau, Receives Award for Research on New Ovarian Cancer Targets - June 16, 2026

Read about New York Genome Center Core Faculty Member, Dr. Dan Landau, Receives Award for Research on New Ovarian Cancer Targets at the New York Genome Center on June 16, 2026

nygenome.org

Beautiful work from @landau.bsky.social! I wonder if with some tweaks if it can be combined with single cell lentiviral barcoding. Single-cell mapping of regulatory DNA-protein interactions: Cell www.cell.com/cell/fulltex...

Single-cell mapping of regulatory DNA-protein interactions

D&D-seq, a single-cell immune-tethering strategy, captures weak and transient DNA-protein interactions to enable integrated, genome-wide analysis of transcription factor binding across chromatin state...

cell.com

D&D-seq, a single-cell immune-tethering strategy, captures weak and transient DNA-protein interactions to enable integrated, genome-wide analysis of transcription factor binding across chromatin states @cellcellpress.bsky.social @landau.bsky.social www.cell.com/cell/fulltex...

This is superb. Congratulations!!

elmo from sesame street is standing in front of a fire

Alt: elmo from sesame street is standing in front of a fire

media.tenor.com

Exciting breakthrough technology from the lab, now live in @cellcellpress.bsky.social ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

What does it take to truly understand #cancer in all of its complexity? Delighted to share our Review in Cell "Cancer ecosystems: A dynamic interplay across scales" with Daniela Quail, where we propose a multi-scale framework connecting tumor ecology with physiology 🧪⚕️ www.cell.com/cell/fulltex...

Woohoo! Excited to be the cover feature!

Elizabeth McKenna@elizsmckenna.bsky.social · 4mo ago

The April issue of Cancer Discovery @aacrjournals.bsky.social is now online! The cover features work by @dennisjyuan.bsky.social, @landau.bsky.social and colleague developing single-cell genotype-to-phenotype sequencing to reconstruct clonal architecture of the phenotypically normal esophagus.

New paper alert 🚀 Our organism-wide single-cell ATAC-seq atlas of mammalian aging is now out in @science.org, led by our fantastic graduate student Ziyu Lu from @rockefeller.edu! www.science.org/doi/10.1126/...

NYC SN❄️❄️❄️❄️❄️❄️❄️❄️❄️W

"We're changing our approach to science philanthropy" -> they're funding AI, just like everyone else

Proud to announce our 2026–2027 Research Grantees! Their innovative research is advancing ovarian cancer early detection and prevention—bringing us closer to a future where every woman has a fighting chance. tinaswish.org/grants-26-27/

The unfounded move by HHSGov against mRNA vaccines will hurt our future potent immune therapy vs cancer. Another point of progress for triple-negative breast cancer with individualized neoantigen mRNA vaccines today Adds to pancreatic, renal cell, melanoma reports nature.com/articles/s41...

Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC - Nature

In a phase 1 trial, personalized mRNA vaccines tailored to individual tumour mutations in triple-negative breast cancer induced robust, long-lasting T cell responses and improved prognosis.

nature.com

As Valentine’s Day #ValentinesDay arrives, here’s one of Ireland’s greatest love poems: Dark-Haired Miriam Ran Away by Patrick Kavanagh (1946), inspired by Hilda Moriarty, a 22-year-old med student he became infatuated with. Later set to music as Raglan Road and famously sung by Luke Kelly.

@landau.bsky.social @rdrapkin8-penn.bsky.social Paul Mischel, and Adam Widman are searching for pre-cancerous signals of ovarian cancer in the blood, laying the foundation for non-invasive screening test. 🩸@tinaswish.bsky.social @weillcornell.bsky.social @mskcancercenter.bsky.social

Absolutely remarkable: striking effects of infusion time-of-day on immunochemotherapy efficacy in nonsmall cell lung cancer in a randomized phase 3 trial www.nature.com/articles/s41...

Time-of-day immunochemotherapy in nonsmall cell lung cancer: a randomized phase 3 trial - Nature Medicine

In this randomized phase 3 trial, patients with treatment-naive stage III–IV nonsmall cell lung cancer who received sintilimab or pembrolizumab in combination with chemotherapy early in the day (befor...

nature.com

Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection. Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social www.nature.com/articles/s41...

Population-scale sequencing resolves determinants of persistent EBV DNA - Nature

Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence and heterogeneous di...

nature.com

Now online in Cancer Discovery @aacrjournals.bsky.social: Genotype-to-Phenotype Mapping of Somatic Clonal Mosaicism via Single-Cell Co-Capture of DNA Mutations & mRNA Transcripts by @dennisjyuan.bsky.social, @landau.bsky.social, et al. doi.org/10.1158/2159... @nygenome.org @weillcornell.bsky.social

Happy new year/paper! A new tech (scG2P) maps genotype (DNA) to phenotype (RNA) in single cells, bringing together the worldviews of genetic & transcriptional heterogeneity. With scG2P we define how mosaicism drivers increase clonal fitness in the aging esophagus aacrjournals.org/cancerdiscov...

Now online in Cancer Discovery @aacrjournals.bsky.social: LINE-1 Locus Transcription Nucleates Oncogenic Chromatin Architecture - by Michael Lee, Yuannyu Zhang, Jian Xu, and colleagues doi.org/10.1158/2159... @stjuderesearch.bsky.social

Excited to see this out www.nature.com/articles/s41...! Nonparametric kernel-based tests for spatially variable isoform usage in spatial transcriptomics. So many interesting examples in the CNS and cancer, we're only scratching the surface!

Mapping isoforms and regulatory mechanisms from spatial transcriptomics data with SPLISOSM - Nature Biotechnology

Differential isoform usage is identified with high statistical power from spatial transcriptomics data.

nature.com

i hate elon musk for a lot of reasons but one of them is that now sometimes i first see interesting papers on linkedin LINKEDIN

Delighted to have our work on 🧬 resilience to 🩸cancer led by @g-agarwal.bsky.social & amazing collaborators, including @kharaslab.bsky.social, published in @science.org: www.science.org/doi/10.1126/... 🧵

His soul swooned slowly as he heard the snow falling faintly through the universe and faintly falling ~ James Joyce Fred Stein

www.sanger.ac.uk/news_item/or...

Order of cancer-driving mutations affects the chance of tumour development

Scientists reveal that mutation order influences tumour growth in the intestine.

sanger.ac.uk