Luca Sclisizzo

@luca-sclisizzo.bsky.social

Psychology student @UniTrieste Website: lsclisizzo.com Interested in behavioral genetics and stats 🧬🧠

Javier and Elliot (and the rest of us, all methodological credit them) did very smart methodological work to speed up GenomicSEM GWAS 800x... Basically they found and implemented a key closed form solution. Go do SEM over millions of SNPs, for tens of traits on a macbook, and it even wont heat up..

@jdelafuente.bsky.social · 3mo ago

1/9 🚨 BREAKING OUT OF STEALTH MODE 🚨 Multivariate GWAS in Genomic SEM now runs on a laptop! New preprint + package update: a closed-form analytic solution makes multivariate GWAS ~800× faster, cutting runtimes from hours on HPC clusters to minutes on a personal computer.

The paper you linked is one of my all time faves. It really forced me to consider the fundamental constraints on the research I do for a living. Yes! And also, what *is* stochasticity? is it true randomness, or some emergent chaos-emerging-from-minute-differences-in-environment thing?