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Can a stem cell change its epigenome while proliferating? In collaboration with the lab of Amos Tanay, we demonstrate that yes, the epigenome of neural stem cells (NSCs) is continuously remodeled, across multiple layers, during mouse corticogenesis. 1/14 www.biorxiv.org/content/10.1...

Neural stem cell epigenomes and fate bias are temporally coordinated during corticogenesis

The cerebral cortex orchestrates complex cognitive functions, yet how its distinct temporal lineages are molecularly patterned during development remains unresolved. Here, we integrate single-cell tra...

biorxiv.org

So glad to see this work preprinted. Thanks @ludoritz.bsky.social for spearheading this massive effort with me and Mariana. There are so many good things in this paper. Thanks to Giuseppe and Raymond for guiding us. Thanks to collaborators, and #HVDAS families. #ADNP #neurodevelopment #multiomics

Ludovico Rizzuti@ludoritz.bsky.social · last yr.

I'm happy to share our work on the neurodevelopmental impact of ADNP mutations in ASD and beyond. It has been an exciting ride to share with @alessandrovitriolo.bsky.social, Mariana, and the people of the Testa and Poot Labs. Full paper here: www.biorxiv.org/content/10.1... Thread below 🧵

I'm happy to share our work on the neurodevelopmental impact of ADNP mutations in ASD and beyond. It has been an exciting ride to share with @alessandrovitriolo.bsky.social, Mariana, and the people of the Testa and Poot Labs. Full paper here: www.biorxiv.org/content/10.1... Thread below 🧵