#M1 Launches First Funding Period & Advances Translation in Munich🚀 Seven projects receive €7.45 million through the M1 – Munich Medicine Alliance. #HelmholtzMunich is involved in four funded projects. 👉 t1p.de/disle @tum.de @lmu.de @boyanbonev.bsky.social @erturklab.bsky.social #MunichMedicine

Out now: we’re happy to share our new preprint on CroCoNet (Cross-species Comparison of Networks), a framework for robust comparative network analyses. 👉 doi.org/10.1101/2025...

Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...

Conservation and alteration of mammalian striatal interneurons - Nature

An analysis of cell-type diversity in brain samples from a variety of mammalian species, both during development and in adult animals, reveals that the TAC3 initial class of striatal interneurons is c...

nature.com

🚀 𝗣𝗼𝘀𝘁𝗱𝗼𝗰 𝗢𝗽𝗲𝗻𝗶𝗻𝗴 We’re recruiting an ERC-funded Postdoctoral Researcher to explore how 3D gene regulatory networks evolved during human and primate brain development, using cutting-edge single-cell multiomics, organoid models, and CRISPR screens. 👉 Apply by Nov 30 | www.bonevlab.com/join

A wonderful collaboration with @alexbaffet.bsky.social @boyanbonev.bsky.social and @neurogenesis-i3s.bsky.social labs

The Hassan Brain Development Team@hassanbraindevlab.bsky.social · 9mo ago

www.biorxiv.org/content/10.1... Our latest: Julien Pigeon and colleagues discover a mechanism linking post-translational modification of transcription factors to remodeling the chromatin landscape to regulate human cortical neurogenesis

Our latest research is online in the @biorxivpreprint.bsky.social! 🧬🎉 🔎 We have developed a novel, single-cell real-time approach to monitor R-loop generated TRCs, and we have shown R-loop-mediated, replisome-controlled transcription repression. www.biorxiv.org/cgi/content/...

Replisome progression regulates R-loop mediated transcriptional repression

Maintaining cellular proliferation necessitates the synchronized activity of diverse molecular machineries operating in parallel on the genome. Wide-spread transcription and R-loop formation can inter...

biorxiv.org

🎤 Apply to speak @our TALENT FORUM by July 31! Showcase YOUR research in Epigenetics & NucleicAcids @www.helmholtz-munich.de & connect with leading scientists 🧳Travel+accommodation covered if selected! 📝 Info+how to apply: lnkd.in/drkRvz7N #postdoc #career #groupleader #HelmholtzMunich #research

Now out in @natneuro.nature.com: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice. Congrats to first authors @annrosebright.bsky.social, Yana Kotlyarenko, @flo-neuhaus.bsky.social, and thanks to all collaborators! www.nature.com/articles/s41... 1/n

Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice - Nature Neuroscience

Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic progenitor mat...

nature.com

Are you @ the late stages of your postdoc ? Want to pursue a PI career ? Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum www.helmholtz-munich.de/en/stem-cell... Peer-networking / Career orientation and more !!! Please distribute :) 🙂

Epigenetics at Helmholtz Munich@epihmgu.bsky.social · last yr.

🎤 Postdocs: want to take the next step and become a #PI? Apply to speak at the TALENT FORUM @www.helmholtz-munich.de, showcase your research in Epigenetics & Nucleic Acids, and connect with top scientists. 🧳 Travel & accommodation covered if selected! 📝 Apply by 31July. 🔗 Info: lnkd.in/drkRvz7N

Out in Cell @cp-cell.bsky.social: Design principles of cell-state-specific enhancers in hematopoiesis 🧬🩸 screen of fully synthetic enhancers in blood progenitors 🤖 AI that creates new cell state specific enhancers 🔍 negative synergies between TFs lead to specificity! www.cell.com/cell/fulltex... 🧵

Design principles of cell-state-specific enhancers in hematopoiesis

Screen of minimalistic enhancers in blood progenitor cells demonstrates widespread dual activator-repressor function of transcription factors (TFs) and enables the model-guided design of cell-state-sp...

cell.com

Check out our latest work on the evolution of animal genome regulation out today in @nature.com. Nicely summarized below by @ianakim.bsky.social. www.nature.com/articles/s41... This is a major output from our ERC-StG project Evocellmap @erc.europa.eu at @crg.eu

Chromatin loops are an ancestral hallmark of the animal regulatory genome - Nature

The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of ...

nature.com

Iana V. Kim@ianakim.bsky.social · last yr.

I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...

In the most recent episode we talked with @boyanbonev.bsky.social from @bonevlab.bsky.social at @epihmgu.bsky.social about his work on neuroepigenetics, focusing on gene regulation, chromatin architecture, and primate epigenome evolution. #epigenetics Listen here: activemotif.com/podcasts-boy...

Can a stem cell change its epigenome while proliferating? In collaboration with the lab of Amos Tanay, we demonstrate that yes, the epigenome of neural stem cells (NSCs) is continuously remodeled, across multiple layers, during mouse corticogenesis. 1/14 www.biorxiv.org/content/10.1...

Neural stem cell epigenomes and fate bias are temporally coordinated during corticogenesis

The cerebral cortex orchestrates complex cognitive functions, yet how its distinct temporal lineages are molecularly patterned during development remains unresolved. Here, we integrate single-cell tra...

biorxiv.org

I'm happy to share our work on the neurodevelopmental impact of ADNP mutations in ASD and beyond. It has been an exciting ride to share with @alessandrovitriolo.bsky.social, Mariana, and the people of the Testa and Poot Labs. Full paper here: www.biorxiv.org/content/10.1... Thread below 🧵

How does gene regulation shape brain evolution? Our new preprint dives into this question in the context of mammalian cerebellum development! rb.gy/dbcxjz Led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social

💫 New preprint from the lab: Comparing great ape cerebral organoids, we found that human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution. Fantastic work from super-talented PhD student Theresa Schütze! www.biorxiv.org/content/10.1...

🚨New preprint from @bonevlab.bsky.social 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex? Here’s what we discovered 👇 www.biorxiv.org/content/10.1...

3D Epigenome Evolution Underlies Divergent Gene Regulatory Programs in Primate Neural Development

The expansion of the neocortex is a hallmark of human evolution and is closely linked to neural stem cell biology. Yet, the epigenetic mechanisms driving divergent gene regulation during primate neuro...

biorxiv.org