Luke Johnson

@lukejohns.online

(Reading this from Bluesky? Follow ap.brid.gy so I can see your replies) Postdoctoral Research Fellow at the Institute for Mechanobiology, Northeastern […] 🌉 bridged from ⁂ https://fedi.lukejohns.online/@luke, follow @ap.brid.gy to interact

RE: https://fedi.lukejohns.online/@luke/116133854514219758 Continuing my Works In Progress posting - this article is overall a good discussion of the differences in hiring and firing flexibility and how it influences how risk-averse companies are. BUT the motivating argument is, er, suspect at […]

Original post on fedi.lukejohns.online

fedi.lukejohns.online

Luke Johnson@lukejohns.online · 5mo ago

One of my favourite little things about the print edition of Works In Progress magazine (you should subscribe! https://worksinprogress.co/print/) is the absurd effort put into a lot of the advert pages.

Marathon day in Boston 👟 Before checking, I was expecting the route to take advantage of all those big waterfront roads and take the runners past a load of landmarks, but nope - just miles and miles of suburbia!

Spotted in CHA Cambridge Hospital: one of these is not like the others! 🏴󠁧󠁢󠁷󠁬󠁳󠁿 🏴󠁧󠁢󠁷󠁬󠁳󠁿 🏴󠁧󠁢󠁷󠁬󠁳󠁿

A large blue welcome banner with the word for "welcome" translated into multiple global languages. One of which is, for some reason, Welsh.

Here's a somewhat scummy thing that Claude does to keep you trapped in the platform: when you export a report to markdown or PDF, the reference hyperlinks aren't included! There's no technical reason for this, just keeping people tied to the service. 😤

I've just finished registering Blue (pictured) in the UK! One interesting thing: for first-time registrations of imported classic cars, the DVLA gives you a period-correct plate number. 1/2

A small blue convertible car overlooking a scenic ocean view.

Today's hearty dishonourable mention goes to Windows 11, which has decided to restart overnight and interrupt an analysis that takes 36 hours... two nights in a row! Don't worry, Microsoft, it's not as if I have an abstract due this week or anything 🙃

We ended up in a place last night where they were explicitly only showing the Super Bowl for the half time show (they even had a "Benito Bowl" special menu!). Given how the actual football went it was probably the best place to be in Boston! #superbowl #badbunny

It is a great honour for my paper on cartilage health after Perthes’ disease to be selected by Arthritis Society Canada as one of their top 10 research advances of 2025! https://arthritis.ca/about-us/news-stories/arthritis-society-canada-top-10-research-advances-2025/

## _Canadian research breakthroughs deliver earlier diagnoses and more effective treatments with the power to change lives_ **January 26, 2026 (TORONTO)** – Arthritis Society Canada announced its Top 10 Research Advances of 2025 today, highlighting discoveries that are advancing how arthritis is diagnosed, treated and prevented. Made possible through the generosity of donors and supporters, these defining studies are accelerating progress toward better outcomes for more than 6 million Canadians living with arthritis, and the millions more at risk. “These discoveries represent innovation in action,” said Dr. Siân Bevan, Chief Science Officer at Arthritis Society Canada. “Thanks to the commitment of our donors and researchers, we are transforming these discoveries into real-world improvements for people living with arthritis – from children needing earlier treatment to women facing increased health risks beyond joint health.” ## Earlier treatment, better outcomes for children with arthritis For children with non-systemic juvenile idiopathic arthritis (JIA), starting biologic medication earlier can significantly improve treatment success, according to research led by Dr. Susanne Benseler at the University of Calgary, and Dr. Rae Yeung from The Hospital for Sick Children, as part of the UCAN CAN-DU and UCAN CURE consortia. The study found that 83% of children who began biologics within 6 months of their initial symptoms achieved inactive disease, compared to 57% of those who waited 13 to 24 months. With each month of delay, the odds of still having active arthritis increased by a relative 9%. These findings reveal a critical window of opportunity for early intervention and could help doctors make more informed decisions about when to initiate biologic therapy, improving the long-term outcomes for children with arthritis. This study marks a critical step towards a cure for childhood arthritis. ## Connecting osteoarthritis and heart disease in women Women with osteoarthritis (OA) face a substantially greater risk of developing cardiovascular disease, according to new research by Dr. Anthony Perruccio from the Schroeder Arthritis Institute at University Health Network. The study found that women with OA had a 90% higher risk of developing cardiovascular disease within six years, compared to women of the same age without OA. By identifying OA as a potential risk marker for cardiovascular disease in women, this research underscores the importance of earlier risk identification and aims to prevent cardiovascular disease and associated deaths in women with OA. “Systemic inflammation may be a key link between osteoarthritis and cardiovascular disease in women,” said Dr. Anthony Perruccio. “Recognizing and addressing this risk earlier could open the door to better prevention strategies and improved long-term health for women living with OA.” ## A pain-free future on the horizon Last year Arthritis Society Canada invested $7 million to drive innovative research aimed at improving arthritis care and reducing pain. From identifying critical windows for early treatment to uncovering new disease connections and potential drug targets, research advances from the past year are deepening our understanding of arthritis and bringing us closer to more personalized, effective therapies. See the full list of **Top 10 Research Advances of 2025**. ### About Arthritis Society Canada Arthritis Society Canada represents the six million people in Canada living with arthritis today, and the millions more who are impacted or at risk. Fueled by the trust and support of our donors and volunteers, Arthritis Society Canada is fighting arthritis with research, advocacy, innovation, information and support. We are Canada’s largest charitable funder of cutting-edge arthritis research. We will not give up our efforts until everyone is free from the agony of arthritis. Arthritis Society Canada is accredited under Imagine Canada’s Standards Program. For more information, visit arthritis.ca. **Media Contact:** Jenny Ng Senior Manager, Communications and Public Relations [email protected] 416-455-1182

arthritis.ca

In 2020, Vancouver Council voted to protect kids by making 30 km/h zones all day around schools. All the city had to do was swap out the old signs. Nearly six years later, they're still not done. Drop pictures of old 8-5 signs in the replies, so we can show council that they need to step it up!

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