Lukas Fiedler
@lukyfiedler.bsky.social
Phd student at ISTA, Swimmer, Auxin, Excited about cells and genomes, Cambridge Biochemistry BA & MSci 🏳️🌈🌱
New Brief Communication: "Cell-based CRISPRa screen identifies a papillae-specific receptor kinase mediating broad-spectrum fungal resistance in rice" rdcu.be/ZZFv8dTuRi8a A RK that positively regulates fungal resistance via silicon-mediated physical & biochemical defences. #PlantScience
Online at @cellcellpress.bsky.social today: everything you always wanted (???) to know about Auxin Signaling and never dared to ask. From Jiashu, Aaron and Martijn in our team, with @luciastrader.bsky.social and Tongda Xu www.sciencedirect.com/science/arti...
sciencedirect.com
Really enjoyed hearing about the creative process of the other young scientists in this episode! Thank you for featuring me @nightsciencepod.bsky.social @itaiyanai.bsky.social
Excited to share our new preprint led by Fred and me in collaboration with the archaeal community! We found that the molecular foundation of histone-based chromatin has pre-eukaryotic roots in Asgard archaea. (1/4) #ArchaeaSky www.biorxiv.org/content/10.6...
Emergence of histone-based chromatin complexity in Asgard archaea
The emergence of the eukaryotes coincided with the diversification of histone proteins and their post-translational modifications by enzymes that constitute the core of eukaryotic chromatin. Yet the e...
biorxiv.org
Preprint: Plant pathogens cleave 2’cADPR to suppress TIR immune signaling Inspired by knowledge on how phages inhibit bacterial immunity, we now show that disease-causing bacteria inhibit plant immunity in a similar way. A 🧵 www.biorxiv.org/content/10.6...
Plant pathogens cleave 2'cADPR to suppress TIR immune signaling
Small molecules produced by TIR (Toll-interleukin-1 receptor) domains are essential for plant immune signaling. A central TIR-derived signal is 2'cADPR, a cyclic ADP-ribose (ADPR) molecule that is gen...
biorxiv.org
Here is our contribution to this lovely special issue. Together with talented PhD students Gabriel and Mung Hsia, we discussed when and how pattern-triggered immunity had been established in plants. doi.org/10.1016/j.cu... @watertoland.bsky.social @mpipz.bsky.social
Redirecting
doi.org
Anne Knowlton@anneknowlton.bsky.social · 3mo agoOur beautiful special issue on plant evolution is out @currentbiology.bsky.social ! www.cell.com/issue/S0960-...
Our work is out now! (www.science.org/doi/10.1126/...). We discover a selective autophagy pathway that protects plants from the mess caused by RNA viruses. Intrigued? Follow the spaghetti trail for a summary of our findings🧵-->
Selective autophagy fine-tunes plant immunity to promote cell survival during viral infection
RNA viruses co-opt host endomembranes to form replication complexes, often triggering cellular stress and immune responses. Here, we show that Arabidopsis thaliana activates selective autophagy to res...
science.org
It's out! 🥳 In situ architecture of #plasmodesmata - plant cytoplasmic bridges - by #cryoET. 📝 Paper: www.nature.com/articles/s41... 🧵 Thread: bsky.app/profile/madi... #teamtomo #proteomics #AlphaFold
In situ architecture of plasmodesmata in Physcomitrium patens resolved by cryo-electron tomography - Nature Plants
Using cryo-electron tomography, the authors reveal how plasmodesmata (plant cytoplasmic bridges) are gated by cell wall remodelling and how helical protein assemblies scaffold internal membranes, with...
nature.com
Marcel Dickmanns | 🌿❄️🔬@madic.bsky.social · last yr.New preprint: In situ Architecture of #Plasmodesmata. Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores. 🔗 doi.org/10.1101/2025... 🧪🧵1/n #teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM
Our work on chromatin evolution in brown algae is now published in @natecoevo.nature.com! We show that developmentally complex brown algae evolved without epigenetic silencing pathways long thought universal, underscoring why non-model lineages are important to study. www.nature.com/articles/s41...
Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating). A brief 🧵 (carried over from the old place)
Nature Portfolio@natureportfolio.nature.com · 7mo agoA study in Nature shows that the single-celled form of a tiny, aquatic organism can turn into a multicellular version by three different routes. The discovery adds insight to the possible origins of multicellular life, suggesting a previously unrecognized degree of flexibility. 🧪
Masters of perception: phosphorylation-dependent signaling in plants #TansleyInsight by Roosjen et al. nph.onlinelibrary.wiley.com/doi/10.1111/... #plantscience
Destigmatize getting things wrong sometimes! Science can gracefully self-correct if we allow it. Well done all around. The cteno vs. sponge saga continues...
Yasin Dagdas@plantophagy.bsky.social · 8mo agoThis is a beautiful case of how real science happens & serious scientists work. Kudos to both set of authors: “This has been a humbling experience, but one that speaks to the self-correcting nature of the scientific endeavor.” www.science.org/doi/10.1126/...
Preprint alert! It is my great pleasure to announce the first manuscript from the lab, a story that started @gmivienna.bsky.social and was mainly accomplished by the intrepid @gesahoffmann.bsky.social at @mpi-mp-potsdam.bsky.social. A brief thread with our findings www.biorxiv.org/content/10.1...
AGO5 restricts virus vertical transmission in plant gametophytes
The propagation of a viral infection from a host parent to its progeny is known as vertical transmission, or seed transmission in plants. It allows viral infections to rapidly spread locally via polle...
biorxiv.org
Wow!! And I naively thought that the 2023 synteny paper supporting ctenophores already settled the dust...
@paveltomancak.bsky.social · 10mo agoThe #sponge #ctenophore scientific oscillator swings again.
This Halloween, we have a spooky evolutionary story for you. The brainchild of @delaconcepcionjc.bsky.social, Nick Irwin and our fantastic collaborators is now out in @natplants.nature.com www.nature.com/articles/s41... Here’s why I love this work — and why I think you’ll enjoy it too. 👇
Previously on BioRxiv, and now a final version of our paper is out! What a great lesson in plant self-organization: Auxin targets its own transporter through a cell-surface kinase complex in a positive feedback loop www.cell.com/cell/fulltex...
ABP1/ABL3-TMK1 cell-surface auxin signaling targets PIN2-mediated auxin fluxes for root gravitropism
In gravistimulated roots, gravity perception in the columella redirects the flow of the plant hormone auxin toward the lower root side, where it inhibits cell elongation for downward root bending. Thi...
cell.com
Remarkable paper explaining how sea slugs maintain chloroplasts obtained by kleptoplasty active for many month & eventually digest them for resources www.cell.com/cell/fulltex...
A host organelle integrates stolen chloroplasts for animal photosynthesis
Sea slugs steal foreign chloroplasts and store them in specialized organelles that facilitate photosynthesis and eventual digestion to mediate starvation resistance.
cell.com
I am heartbroken about the loss of many labs at the Weizmann Institute yesterday in the missile attack. Dear scientists there: please know that you are not alone. Like many many others, I support you and am standing by to help you in any way I can.
If you want to improvise the dance moves to just about any song, pretend you are doing laundry, it's very easy
Itai Yanai@itaiyanai.bsky.social · last yr.Lucas Fiedler at the #TCTEAC @lukyfiedler.bsky.social
