“move from preprint to peer-reviewed publication leaves the central claims of most abstracts intact, indicating preprints are a reliable source…papers that were never posted as preprints were retracted at roughly twice the rate of those that were…” www.biorxiv.org/content/10.6...

Tracking claim changes from preprint to publication across 72,644 biomedical studies using large language models

Preprints now disseminate a large share of biomedical research before peer review. Because they have not yet passed peer review, some scientists regard preprint claims as unverified or potentially unr...

biorxiv.org

#pictureofthemonth: Plant cells use tiny pores called plasmodesmata to talk to each other. The rendering, shows how everything links together. More: www.biochem.mpg.de/baumeister-p... July – Calendar of @mpiforbi.bsky.social and @mpibiochem.bsky.social 📸 by Monika Krause & Marcel Dickmanns

1/8 What if the genomic features we associate with fungal pathogens were also used by mutualists? We assembled 41 scale lichen genomes across 11 Peltigera species with 30 chromosome scale and 5 T2T revealing an unexpected genomic toolkit behind lichen symbiosis. doi.org/10.64898/202... #lichen

A chromosome-scale super-pangenome of the lichen genus Peltigera reveals genome architecture and expanded interaction repertoires shared across pathogenic and mutualistic fungi

Fungi engage in associations with other organisms across a continuum from pathogenic to mutualistic lifestyles. Hence, they require a compendium of molecular capacities, including partner recognition,...

doi.org

Happy to finally share that I will be starting my independent group at the @fmiscience.bsky.social in Feb 2027 in a vibrant new environment. We will use integrative in situ structural cell biology methods to investigate ciliary structure and dynamics in several model (and non-model 👀) systems!!

Better vitrification = better cryo-ET. We've opened an RFA for two-year grants to advance vitrification techniques for biological samples—welcoming applications from researchers in heat transfer, cryogenics, and materials science. Apply here: bit.ly/4uip6eJ

Check out our latest work! AlphaFold 3 revealed a transient immune receptor complex that eluded biochemical studies for almost a decade 🤯 We describe a conserved structural logic underlying sensor–helper communication in an NLR immune receptor network 🧵👇

bioRxiv Plant Bio@biorxiv-plants.bsky.social · 3mo ago

A conserved structural logic underlies sensor-helper NLR communication in the NRC immune receptor network https://www.biorxiv.org/content/10.64898/2026.05.18.725810v1

Thrilled to share the updated video of my paper in Nature with Maciej (under supervision of @simonemattei.bsky.social & @jomaalab.bsky.social) Proud to use Cryo-ET to uncover how hibernation factors are key to translation restart! To model PTMs in situ and render animations fulfilled my PhD dream!🥹🎉

EMBL@embl.org · 3mo ago

Despite its name, SNOR, a newly discovered protein, is hardly asleep on the job. EMBL researchers’ newest technologies allowed their scientific collaboration to discover a tiny protein with a big role in awakening cells from dormancy to restart protein synthesis. www.embl.org/news/science...

We have an open-rank professorship position open @unileiden.bsky.social Institute of Biology: careers.universiteitleiden.nl/job/Assistan... welcome to apply! due: 7 June

New OA Article: "In situ architecture of plasmodesmata in Physcomitrium resolved by cryo-electron tomography" rdcu.be/fjjiK Plasmodesmata are gated by cell wall remodelling; helical protein assemblies scaffold internal membranes; implications for molecular filtering.

It's finally out! Molecular architecture of mammalian AP3:ARF1 carriers - a mechanism for lysosomal membrane protein trafficking - from a combination of #biochemistry, #cryoET and #cellbiology 📝 Paper: www.science.org/doi/10.1126/... 🧵 Thread: subsequently #teamtomo #membranetrafficking

Briggs Group@briggsgroup.bsky.social · 3mo ago

The architecture of carriers formed by AP3:ARF1 for lysosomal membrane protein transport: www.science.org/doi/10.1126/.... Work from @jggkaufman.bsky.social, in collaboration with @dgershlick.bsky.social and David Owen. @mpibiochem.bsky.social @thecimr.bsky.social

It's out! 🥳 In situ architecture of #plasmodesmata - plant cytoplasmic bridges - by #cryoET. 📝 Paper: www.nature.com/articles/s41... 🧵 Thread: bsky.app/profile/madi... #teamtomo #proteomics #AlphaFold

In situ architecture of plasmodesmata in Physcomitrium patens resolved by cryo-electron tomography - Nature Plants

Using cryo-electron tomography, the authors reveal how plasmodesmata (plant cytoplasmic bridges) are gated by cell wall remodelling and how helical protein assemblies scaffold internal membranes, with...

nature.com

Marcel Dickmanns | 🌿❄️🔬@madic.bsky.social · last yr.

New preprint: In situ Architecture of #Plasmodesmata. Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores. 🔗 doi.org/10.1101/2025... 🧪🧵1/n #teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

New preprint 🚀 ❄️ We developed Autogrid-compatible HPF planchettes that enable direct freezing of clipped EM grids and streamline integration with cryo-FIB workflows ✔️ improved grid stability ✔️ reduced handling ✔️ robust vitrification (🦠 🧫 🧠) A step toward routine HPF for complex samples #teamtomo

Check out our new release on BioRxiv co-lead by @pm-mueller.bsky.social 👉 rb.gy/lnrizk special🙏 to Severine Kunz #MDC @leventallab.bsky.social @andimicroscopy.bsky.social @ewerslab.bsky.social and Kedar Narayan @NCI CCR VolumeEM Are the days of discovering new cellular structures over?? /1

I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...

A new webinar series is born - ''MechanoBioTalks - Mechanics, Materials and Living Matter", to bring together and inspire researchers interested in biomechanics, biophysics and biology across different kingdoms of life. Join us! For info and registration visit green-te.nl/activities/

Activities - GreenTE

Activities Webinars ”MechanoBioTalks – Mechanics, Materials and Living Matter” is a webinar series supported by the GreenTE consortium and organized […]

green-te.nl

Our work on #hornwort #pyrenoids is finally out in @science.org! 🎉 We uncovered how hornworts pack their Rubisco into pyrenoids and successfully recreated them in Arabidopsis. A key step toward engineering more efficient photosynthesis in crops @btiscience.bsky.social www.science.org/doi/10.1126/...

An unconventional Rubisco small subunit underpins the CO2-concentrating organelle in land plants

In many algae, photosynthesis is boosted by biophysical CO2-concentrating mechanisms, which pack the CO2-fixing enzyme Rubisco into liquid-like organelles called pyrenoids. Engineering C3 crops with a...

science.org

Excited to announce I’m starting a new lab at @gmivienna.bsky.social (Vienna BioCentre) in Sept 2026 We study how carbon fixation is inherited and maintained in algae using cryo-ET, imaging, environmental sampling&more Looking for people who want to build the lab together, get in touch! #teamtomo

We are currently recruiting PhD students, postdocs, and a group leader to join the Institute. If you’re interested, please send me a personal message or email your CV and a brief motivation letter to: johannes.rebelein@hhu.de.

Thrilled to share that our preprint has been accepted in Science Advances! Grateful to an incredible team & collaborators. Link: www.science.org/doi/10.1126/... 👏 @annaferraioli.bsky.social @maikekittelmann.bsky.social @msarscentre.bsky.social @erc.europa.eu @hfspo.bsky.social #ctenophores

The 3D architecture of the ctenophore aboral organ and the evolution of complex integrative centers in animals

The ctenophore aboral organ integrates multimodal sensory signals across distinct cell types.

science.org

Pawel Burkhardt@pawelburkhardt.bsky.social · 12mo ago

Ctenophores possess a unique aboral organ that acts as a multisensory center, controlling complex behaviors. We’ve now created a ctenophore model integrated with our 3D volume EM data. Puts it into perspective. Check out our recent work here: www.biorxiv.org/content/10.1... #ctenophores #volumeEM

🌱Save the date! It’s time to plant the seeds of discovery at our 4th edition of #PlantResearch26. From roots to results, explore breakthroughs in genetics, sustainability, crop innovation, and future food systems. Let’s grow ideas together, in Ghent, 17-18 September: vibbio.tech/4s31Pg5 #VIBConf

Students out there, I have a PhD project cutting across biology, material science and biomedicine that requires a highly capable, diverse and brave applicant. if you think this is for you please Apply using the link below. All details in the website!! Project: eb4bm.org/project/engi...

I had Claude make this as a mini-game for Relay's disconnect screen (like Chrome's dinosaur), but then pivoted to stand-alone. In this game, you have to find Euler angles matching the target projection, i.e. cosplay RELION. It can be pretty hard. Works on mobile too! warpem.github.io/euler-hunt/

Euler Hunt

Can you find the Euler angles of a cryo-EM projection?

warpem.github.io

Benthamiana rhapsody 🎶 🌱 How benthi is the go-to system for cracking the activation mechanism of an Arabidopsis TIR-NLR immune receptor— that’s the rhapsody. Congrats He Zhao and Selvaraj for this wonderful collaboration 👇🏼 doi.org/10.64898/202...

We genetically disconnected starch from the matrix in the algal pyrenoid! A saga1;saga2 double mutant lacks a starch sheath! Our model: SAGA1 & SAGA2 locally initiate starch on the pyrenoid surface by enriching starch precursors. 🌞🦠🔬🔌👀 www.biorxiv.org/content/10.6...

You like #LLPS? #TeamTomo? #Rubisco? Check out our latest preprint! What a great collaboration this has been!

James Barrett@james-r-barrett.bsky.social · 6mo ago

How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵 Preprint here!: www.biorxiv.org/content/10.6... @cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social #Rubisco #PhaseSeparation #Condensates #Pyrenoid

Excited to finally share this work also in written form! 🎉 Huge thanks to all co-authors and collaborators — this really was a team effort, and I’m very grateful for all the ideas, discussions, and hard work that went into it. Thanks everyone! #TeamTomo #cryoET #autophagy

Wilfling Lab@wilflinglab.bsky.social · 7mo ago

We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉

It makes me sad to see a paper in a fancy journal that I didn't see on bioRxiv before 😢

Gorgeous paper and a plea for open data. ⬇️ See thread ⬇️

Ricardo D. Righetto@lifeonthewedge.bsky.social · 7mo ago

This one was quite the journey! The paper describing the #ChlamyDataset is finally out and on the cover of Mol Cell! This beautiful rendering made by co-author @jessheebner.bsky.social and Holly Peterson shows an instance of mitochondrial fission found in the dataset 😍 [Maybe long thread ahead]

Microsoft spell check trying to sabotage reviewer replies again 🙄