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Jeremy Kamil

@macroliter.bsky.social

[He, him.] CMV virologist exploring how viruses enter cells and other tricky mischief (lately, of the glycoimmune-centric variety). University of Pittsburgh School of Medicine. My posts here are my own speech, not my employer’s. #LoveVirology #Glycotime

928 Posts8386 Follower4211 Folgt
Thiago Carvalho@cyrilpedia.bsky.social · last wk.

'Deprived of classical resistance pathways because of their fitness costs in vivo, pneumococcal populations convergently evolved mutations in rny (...) Unlike drug-specific resistance mechanisms, rny mutations emerged across diverse antibiotic classes and immune states'

RNA quality control enables antibiotic tolerance

Antibiotic resistance poses significant challenges, yet pathogen adaptation pathways vary. To determine how host environments affect adaptation, we ex…

sciencedirect.com

Prof Jenny Rohn@jennyrohn.bsky.social · last wk.

A ribosomal “crash and reboot” strategy for bacterial response to antibiotics Super interesting work about the battling selection pressures of #antibiotics vs #immunity in vivo #AMR #IDSky #MIcroSKy

Vaughn Cooper@vscooper.micropopbio.org · last wk.

In 2014, Jason Rosch and I met at a GRC in Tuscany and sketched an idea on a cocktail napkin: what if we evolved S.pneumo in mice, treated them with antibiotics, varied their immune systems and watched what won? 11 years and a huge team effort later, it's out in @cp-cellhostmicrobe.bsky.social 🧵

Amy Maxmen, PhD@amymaxmen.bsky.social · 2w ago

🧵The US no longer meets criteria for measles elimination. Utah's outbreak has lasted for more than a yr. And cases this yr are at a 35-yr high. I talked w/pediatricians treating measles & talking w/parents who don't vaccinate. My latest @wired.com @kffhealthnews.org www.wired.com/story/the-ch...

‘The Child Is Terrified’: Measles Doctors Speak Out

Hear from six pediatricians in measles hot spot Utah, as the US faces infection levels not seen in over three decades and prepares to lose its status as a country that eliminated the dangerous disease...

wired.com

Julian Sanchez@normative.bsky.social · 2w ago

Absolutely everybody who knows anything about labor demographics saw this coming miles away. The last 18 months have been a steady stream of “nobody could have predicted” things every minimally knowledgable person loudly predicted.

Anna O. Law@unlawfulentries.bsky.social · 2w ago

Eldercare is hard work, severely underpaid that was already understaffed. Since Medicaid is "the primary payer" of this work, it's unlikely there will be a huge increase in wages to attract non-immigrant workers. Are Americans prepared to quit their jobs to take care of their elders? Many have.

The New Yorker@newyorker.com · last mo.

As many as half a million Americans have been afflicted with alpha-gal syndrome—a tick-borne disease that can cause a life-threatening allergy to red meat. Burkhard Bilger reports on the epidemic. newyorkermag.visitlink.me/dzPniM

The Tick That Hunts Down Its Hosts—Including Us

Lone-star ticks don’t just pursue and bite people. The affliction they’re spreading, an allergy to red meat known as alpha-gal syndrome, attacks a way of life.

newyorkermag.visitlink.me

Stand Up for Science!@standupforscience.net · last mo.

🚨 HEADS UP: If you haven't submitted a comment on the OMB proposal yet, there's still time - but it's running out! There are only 10 days left to push back against Russell Vought's attempt to give political appointees unprecedented control over federal research funding. Take Action: zurl.co/Bl59I

Graphic from Stand Up for Science urging action on a federal funding proposal. Large text reads: "10 Days Left" and "Help Us Stop Vought From Destroying American Science." A portrait of Russell Vought appears beside the U.S. Capitol. A banner along the bottom reads: "Submit a comment on the OMB proposal | Link in bio to take action." The Stand Up for Science logo appears in the top left.
Jason Scott@textfiles.com · last mo.

I'll summarize this: Mamdani asked NYers to keep air conditioning at 78 degrees. A wave criticism hit online. A MSNBC broadcast pointed out the US Department of Energy recommends that 78 degree figure. Immediately after, the US Department of Energy deleted 6,000 web pages related to energy saving.

Nikolai Slavov@slavov-n.bsky.social · last mo.

Since the 1960s, the genetic code has been used to predict protein sequences from DNA and mRNA sequences. Our @nature.com article demonstrates that these predictions miss thousands of protein sequences present in human tissues. www.nature.com/articles/s41... 1/

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Nikolai Slavov@slavov-n.bsky.social · 2y ago

We report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. www.biorxiv.org/content/10.1...

Jeremy Kamil@macroliter.bsky.social · last mo.

Amazing recap (and how’s it possible we are now hurtling toward “Seven years ago..” instead of 5?)

Flo Débarre@flodebarre.eurosky.social · 2y ago

Five years ago (27 Dec 2019), the first complete sequence of a new coronavirus infecting humans was obtained at Vision Medicals, a sequencing lab in Guangzhou, confirming a preliminary result from the previous day. The sample was from a 65yo Wuhan patient linked to the Huanan market archive.ph/DpZkX

screenshot of a phylogenetic tree, showing the new sequence clustering with other SARS-like coronaviruses
Norma@looftsabine.bsky.social · last mo.

⬆️ worth reading "How the U.S. is losing ground to China in university research" COREY: You know, it may be that we can tell somebody, yeah, there's going to be a cure for your deaf child. NADWORNY: You just might have to go to Shanghai, he says, to get it.

Leah Stokes@leahstokes.bsky.social · last mo.

The heatwave in Europe is so extreme, it's 25–32°F (14–18°C) above normal. You read that right. France recorded it's hottest day ever. The UK had its hottest ever June day. The ground is exceeding 122°F (50°C). People are dying. Tell me again why we shouldn't talk about climate change???

David Ho@davidho.bsky.social · last mo.

The rise of larger vehicles like SUVs and pickup trucks, with their taller hoods and larger blind zones, has contributed to a 75% increase in pedestrian and cyclist deaths since 2009. Until we design better streets and ban these vehicles, people outside these vehicles will keep dying.

The Deadly Rise of Giant Trucks and S.U.V.s (Gift Article)

The vehicles on American roads have grown larger — and they are killing thousands more pedestrians, a Times investigation found.

nytimes.com

Center for Biological Diversity@biologicaldiversity.org · 2mo ago

We scored a legal victory requiring the U.S. Fish and Wildlife Service to finalize Endangered Species Act protections for the critically imperiled Kern Canyon and relictual slender salamanders by December 2026. Learn more. ⬇️

Two California Salamanders Move Closer to Endangered Species Protection

CARLSBAD, Calif.— The Center for Biological Diversity has scored a legal victory requiring the U.S. Fish and Wildlife Service to finalize Endangered Species Act protections for the critically imperile...

biologicaldiversity.org