Improving Identification of In-organello Protein-Protein Interactions Using an Affinity-enrichable, Isotopically Coded, and Mass Spectrometry-cleavable Chemical Crosslinker

An experimental and computational approach for identification of protein-protein interactions by ex vivo chemical crosslinking and mass spectrometry (…

sciencedirect.com

Proteome-wide Monitoring of Drug Action in Living Cells using a Novel Label-free Solvent-based Shift Assay

Biophysical proteomics assays allow for proteome-wide, label-free monitoring of ligand-induced changes in protein structure and stability, offering insights into protein-ligand interactions and modula...

mcponline.org

Robot metabolism: Toward machines that can grow by consuming other machines

Robots grow bigger, faster, and more capable by absorbing and integrating material in their environment.

science.org

Introduction to BioMCP

YouTube video by GenomOncology

youtu.be

Show Your Stripes

Visualising how the climate has changed for every country across the globe

showyourstripes.info

Research Workflow with Quarto + {targets} – Kazuharu Yanagimoto

kazuyanagimoto.com

GitHub - t-kalinowski/quickr: R to Fortran Transpiler

R to Fortran Transpiler. Contribute to t-kalinowski/quickr development by creating an account on GitHub.

github.com

shikokuchuo{net}: mirai 2.3.0

Advancing Async Computing in R

shikokuchuo.net

NIH scientists call on director to protect biomedical research

In a public letter, hundreds of scientists expressed their dissent to the Trump administration's policies affecting the National Institutes of Health and called on its director to support the agency.

npr.org

I’m the Canadian who was detained by Ice for two weeks. It felt like I had been kidnapped

I was stuck in a freezing cell without explanation despite eventually having lawyers and media attention. Yet, compared with others, I was lucky

theguardian.com

The War on Science

open.spotify.com

iSODA: A Comprehensive Tool for Integrative Omics Data Analysis in Single- and Multi-Omics Experiments

Thanks to the plummeting costs of continuously evolving omics analytical platforms, research centers collect multiomics data more routinely. They are, however, confronted with the lack of a versatile software solution to harmoniously analyze single-omics and interpret multiomics data. We have developed iSODA, a web-based application for the analysis of single- and multiomics data. The tool emphasizes intuitive interactive visualizations designed for user-driven data exploration. Researchers can access a variety of functions ranging from simple visualization like volcano plots and PCA to advanced functional analyses like enrichment analysis and lipid saturation analysis. For integrated multiomics, iSODA incorporates multi-omics factor analysis and similarity network fusion. The ability to adapt the data on-the-fly allows for tasks, such as the removal of outlier samples or failed features, imputation, or normalization. All results are presented through interactive plots, the modular design supports extensions, and tooltips and tutorials provide comprehensive guidance for users. iSODA is accessible under http://isoda.online/.

pubs.acs.org

Remembering what I did this week with LLMs – Garrick Aden-Buie

Using the GitHub API and {ellmer} to remember what I did this week.

garrickadenbuie.com

The UVic logo: how it’s going, and where it started

UVic unveiled a new logo collection, or “mark,” last month, signifying the start of a new design era for the university.

martlet.ca

π-HuB: the proteomic navigator of the human body

Nature - We introduce a major scientific endeavour called π-HuB (proteomic navigator of the human body), its aim being to generate and harness multimodality proteomic datasets to enhance our...

rdcu.be

Introducing Positron, a new data science IDE - posit conf 2024

YouTube video by Posit PBC

youtu.be