Michał Małszycki

@malszycki.bsky.social

Postdoc in the Laboratory of RNA Biology at IIMCB in Warsaw 🧬🔬 Passionate about Evolution and RNA Biology.

I’m thrilled to share that my PhD work has been just published in Cell. After a long and bumpy ride, we uncovered the core function of nuclear speckles -splicing of GC-levelled exons- and traced the evolution of this gene architecture and condensates themselves to amniotes.

Graphical abstract: Speckle-proximal and speckle-dependent RNA has short introns, and simultaneous emergence of multiple exons requires heightened concentration of spliceosome components.
Speckle-independent RNA has long introns and can be spliced well with or without speckles
Speckle dependent introns evolved in amniotes. The reduction in intron length was accompanied by the increase of the intronic GC content, giving rise to GC-levelled intronic architecture. This exon-intron architecture is not present outside of amniotes (Fish, Invertebrates), and these organisms lack nuclear speckles.
Tugce Aktas@aktast.bsky.social · 5mo ago

Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social doi.org/10.1016/j.ce... Read the thread👇 for the highlights of our findings.

Państwo, które rezygnuje z nagradzania jakości i odwagi konkurowania w nauce, samo ogranicza swoje aspiracje i ustępuje miejsca przy światowym stole. System powinien wzmacniać, a nie wyrównywać w dół – pisze dziś w FA prof. Magdalena Musiał-Karg z Uniwersytetu im. Adama Mickiewicza w Poznaniu ⬇️

Między ambicją a wygodą

Debata o przyszłym kształcie listy czasopism w Polsce coraz częściej przybiera ton tożsamościowy. Padają określenia „globaliści”, „lokaliści”, „scopusowcy”, pojawiają się sugestie o klasowym charakter...

forumakademickie.pl

Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!

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🔥 New episode of the Night Science Podcast! Maria Leptin is the President of the ERC, the European Research Council. She discusses how funding agencies can better support bold ideas and we explore how to evaluate creativity in grant proposals. @marialep.bsky.social open.spotify.com/episode/2AJj...

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Itai Yanai@itaiyanai.bsky.social · 8mo ago

I don't think scientists should work for anyone else. They should work for discovery and for their own curiosity. – Maria Leptin, ERC President @marialep.bsky.social (From the episode of the Night Science Podcast coming out next week @nightsciencepod.bsky.social )