Lab summer social a few weeks ago in Oxford, during which we did some punting and played some darts

We're looking for a Senior Computational Postdoc to help us analyse our single-cell, spatial and epigenomics data from mouse models and to cross-reference these analyses with data from human tumours. Please get in touch if you're interested! shorturl.at/yXwpC

a cartoon of calvin from the calvin and hobbes comic strip

ALT: a cartoon of calvin from the calvin and hobbes comic strip

media.tenor.com

Anthropic cofounder says studying the humanities will be ‘more important than ever’ and reveals what the AI company looks for when hiring fortune.com/2026/02/07/a...

Anthropic cofounder says studying the humanities will be 'more important than ever' and reveals what the AI company looks for when hiring | Fortune

"The things that make us human will become much more important instead of much less important."

fortune.com

We're seeking to fill two roles: a PDRA and an RA. These positions will investigate resistance mechanisms in brain tumour models using in vivo models, spatial omics, CRISPR. Please apply if previous experience aligns! Here is the RA job advertisement: shorturl.at/NVl1V

We're seeking to fill two roles: a postdoc and a research assistant. Both will focus on resistance mechanisms in brain tumour models using various approaches (in vivo, spatial omics, CRISPR). Please apply if this aligns with your previous experience! shorturl.at/hZ6mG

a close up of a feather on a rock with the words `` hello '' written in white letters .

ALT: a close up of a feather on a rock with the words `` hello '' written in white letters .

media.tenor.com

The reforms to UKRI under Ian Chapman are only just starting, but there are already worries about what they mean for the bread and butter, applicant-led funding calls at research councils While UKRI insists comparisons with previous years are impossible, figures from December suggest...

Please share or forward to anyone interested in joining our lab as a research assistant, details can be found via the link below shorturl.at/x0cSs

a penguin wearing a red bandana and a tie looks through binoculars

Alt: a penguin wearing a red bandana and a tie looks through binoculars

media.tenor.com

Please share or forward to anyone interested in joining our lab for a postdoc, details can be found via the link below shorturl.at/GMbW0

a woman in a yellow wig and white sunglasses

ALT: a woman in a yellow wig and white sunglasses

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The Pathania lab will be moving to the Ludwig Institute in Oxford in early 2026. We'll be recruiting postdocs and research assistants soon, so keep an eye out for those job ads and reach out if you want to find out more about the science we have planned! shorturl.at/thpyK

Ludwig Oxford welcomes Dr Manav Pathania

Ludwig Oxford is delighted to welcome Dr Manav Pathania as an Assistant Member of the Ludwig Institute for Cancer Research, Oxford Branch.

shorturl.at

🪰 folks! I spoke to the Transmitter about FlyBase. As noted at flybase.org, bridge $ ran out and many staff were laid off. Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2 tinyurl.com/FlyBase

FlyBase secures funding for year, but future still uncertain

The FlyBase team’s fundraising efforts have proven successful in the short term, but restoration of its federal grant remains uncertain.

tinyurl.com

Yes, it was carefully hidden in the New England Journal of Medicine. Pfizer/BioNTech vaccine (www.nejm.org/doi/pdf/10.1... ) 1/2

Elizabeth Jacobs, PhD@elizabethjacobs.bsky.social · 11mo ago

Trump on RFK Jr., the CDC, and vaccines (a translation). He seems to be saying that he was shown data about COVID19 vaccines being safe and effective, but that the pharma companies didn’t show those amazing data to anyone else, like RFK Jr. He thinks this is why there is a “mess” at CDC.

When mRNA vaccines are wrongly attacked, this is one of many examples of what you're missing. A broad spectrum prevention strategy against viruses www.science.org/doi/10.1126/...

Farewell for Carmo, RA extraordinaire! Good luck in your PhD at the Crick and thanks for all your hard work over the last 3 years!

WOW!!!!!😱😮 High-speed mapping of whole-mouse peripheral nerves at subcellular resolution: Cell www.cell.com/cell/fulltex...

High-speed mapping of whole-mouse peripheral nerves at subcellular resolution

A high-speed pipeline enables whole-mouse imaging and mesoscopic analysis of peripheral nerves using transgenic, immunostaining, and viral labeling, providing an effective means to map body-wide struc...

cell.com

A study in Nature Medicine shows the mechanisms driving amyloid-β clearance in both passively and actively Aβ immunized patients with Alzheimer’s disease. #alzsky 🧪

Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease - Nature Medicine

Spatial transcriptomics reveals distinct microglial mechanisms driving amyloid-β clearance in both passively and actively immunized patients with Alzheimer’s disease.

go.nature.com

Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human length 👉 These mice, with humanized telomere regulation, represent a valuable model to study human aging and cancer. www.nature.com/articles/s41...

Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human length - Nature Communications

Mice models often fail to reflect human telomere biology. Here, the authors engineer a mouse strain with a humanized mTert gene, restoring telomere length regulation to a human-like pattern. This mode...

nature.com

From a journalist friend: Just spreading the word. The CDC is purging data, so people should archive their favorite CDC datasets today, namely ones around race/ethnic diversity, LGBTQ, and reproductive health. Also health data involving climate. The youth risk behavior survey has already gone down.

Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding www.sciencedirect.com/science/arti...

Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding

Glioblastoma is a highly aggressive primary brain tumor with glioblastoma stem cells (GSCs) enforcing the intra-tumoral hierarchy. Plasma cells (PCs) …

sciencedirect.com

Buon Anno!!

Merry Christmas!

Rounding out the year with the team

I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪

Regulation of human interferon signaling by transposon exonization

Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.

cell.com

Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...

Cancer cells impair monocyte-mediated T cell stimulation to evade immunity - Nature

Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.

nature.com

Anna Obenauf@obenaufa.bsky.social · 2y ago

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma www.nature.com/articles/s41...

Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma - Nature

The prodrug gliocidin effectively kills glioblastoma cells by targeting de novo purine synthesis, improving survival in mouse models.

nature.com

Happy International Day of LGBQTIA+ People in STEM! Proud to advocate for the enriching benefits of diversity, of experiences and viewpoints, IRL and on this platform.

Pride in STEM@prideinstem.bsky.social · 2y ago

November 18 is the International Day of LGBQTIA+ People in STEM! Today more than ever we want to stress the importance of communities, building connections, and raising each other up. Let's keep leaving our mark for the betterment of us all! 🏳️‍⚧️🏳️‍🌈 #QueerinSTEM prideinstem.org/lgbtstemday/

Hi Bluesky! I am a PI in the Dept of Oncology at the University of Cambridge, UK. Our lab develops mouse models of different types of brain tumours and uses these to explore targeted treatments, TME interactions, and the role of heterogeneity in resistance. doi.org/10.1158/2159...

A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities

Models of pediatric high-grade glioma reveal genotype–phenotype associations, differences in cell type composition, and sensitivity to targeted and combination therapy approaches, making preclinical e...

doi.org

Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas Incredible study now out in Nature, with long-term remission for pediatric glioma Michelle Monje, Crystal Mackall et al Well done to all the authors for this true tour de force! 🧪⚕️🩺 www.nature.com/articles/s41...

I reserved my first Bluesky post to mark another enjoyable and successful collaboration with the Jabado and Kleinman labs! Congrats to @selinjessa.bsky.social, Bhavyaa and Antonella on this cool paper! doi.org/10.1158/0008...

FOXR2 targets LHX6+/DLX+ neural lineages to drive CNS neuroblastoma

Abstract. Central nervous system neuroblastoma with FOXR2 activation (NB-FOXR2) is a high-grade tumor of the brain hemispheres and a newly identified molecular entity. Tumors express dual neuronal and...

doi.org