Happy to share our new paper in Gut Microbes 🧬 Samer Alban and I developed EcoGS, a genome-scale metabolic modelling tool for predicting ecological interactions between microbes. As first author, I thank Samer, @kaletalab.bsky.social, and all co-authors for the teamwork! doi.org/10.1080/1949...

Genome-scale metabolic models predict diet- and lifestyle-driven shifts of ecological interactions in the gut microbiome

Microbiomes and their host environments form complex, interconnected ecosystems. The microbial species within a microbiome, on the one hand, compete for resources, while on the other hand, they exc...

doi.org

Our Virtual Colon model is featured in Happiest Health. 📰We show that gut bacteria may behave differently depending on their location in the colon 🧬 — a spatial perspective relevant for host–microbiome interactions and personalised gut health. Article: www.happiesthealth.com/articles/gut...

Relooking the gut with a new computer model

A new computer model of the colon shows that gut bacteria behave differently depending on where they are — upending a long-held assumption that the gut works as one uniform system

happiesthealth.com

Christoph Kaleta@kaletalab.bsky.social · 8mo ago

(1/7) Excited that the Virtual Colon, an extension of BacArena for modeling the spatiostructural environment of the colon, is now out at mSystems. Kudos to @maringos.bsky.social and for leading this work! @crc1182.bsky.social @uni-kiel.de iel.de Link: journals.asm.org/doi/full/10....

You can also find the full paper here: rdcu.be/e74Ou 📄 As my first study as a senior author, this marks an important milestone—and the starting point for many new projects, directions, and ideas 🚀

Dietary patterns influence the in silico GABA production capacity of Bifidobacterium adolescentis HD17T2H and other human gut bacteria

Scientific Reports - Dietary patterns influence the in silico GABA production capacity of Bifidobacterium adolescentis HD17T2H and other human gut bacteria

rdcu.be

Christoph Kaleta@kaletalab.bsky.social · 5mo ago

Can diet shape your microbiome’s ability to produce neuroactive compounds? Our latest study shows dietary patterns influence in silico GABA production capability by Bifidobacterium adolescentis and other gut bacteria. Led by Ann Homscheid and @maringos.bsky.social. doi.org/10.1038/s415...

Excited to see our work published. Thanks for the support, Johannes Zimmermann, Jan Taubenheim, @kaletalab.bsky.social and our funding bodies.

Christoph Kaleta@kaletalab.bsky.social · 8mo ago

(1/7) Excited that the Virtual Colon, an extension of BacArena for modeling the spatiostructural environment of the colon, is now out at mSystems. Kudos to @maringos.bsky.social and for leading this work! @crc1182.bsky.social @uni-kiel.de iel.de Link: journals.asm.org/doi/full/10....

Thrilled to announce the publication of my first article as last & corresponding author! This opinion piece in BIOspektrum, written with Ms Ann Homscheid and Prof Dr Kaleta, explores how Systems Biology can be used to disentangle complex diseases. Access: rdcu.be/ersH6

Christoph Kaleta@kaletalab.bsky.social · last yr.

Great article about Medical Systems Biology by Ann Homscheid and @maringos.bsky.social from the lab in BIOspektrum (in German): link.springer.com/article/10.1...

Great article about Medical Systems Biology by Ann Homscheid and @maringos.bsky.social from the lab in BIOspektrum (in German): link.springer.com/article/10.1...

Vernetzt denken – mit Systembiologie Krankheiten verstehen - BIOspektrum

BIOspektrum -

link.springer.com

Honoured to be part of that project. Well done @sci-witch.bsky.social !

Christoph Kaleta@kaletalab.bsky.social · last yr.

1/12 Thrilled to share our latest paper on host-microbiome-interactions in aging out in Nature Microbiology @naturemicrobiol.bsky.social, great work led by Lena Best @sci-witch.bsky.social with the Frahm lab within the ITN SmartAge. @crc1182.bsky.social @uni-kiel.de www.nature.com/articles/s41...

Proudly presenting Virtual Colon, our modelling software for host-microbial metabolic spatiotemporal interactions in the mammalian large intestine, during the Kiel Life Sciences Retreat 2024, in Schleswig, Germany. Thanks to all the participants and to @kaletalab.bsky.social & @kamoors.bsky.social!

Hi everyone! I'm Yorgos, a scientist originally from GR, living in DE for ~ 10 years. I like microbiome & skin ageing projects. Currently, I'm collaborating with Beiersdorf, focusing on analysing, visualizing and interpreting metabolic modelling, omics & cohort data. Excited to connect with you all!