Nachgefragt: Prof. Dr. Christoph Kaleta im Interview www.biospektrum.de/artikel/nach... @kaletalab.bsky.social Copyright rechter Bildteil: Sascha Klahn, 2024
Christoph Kaleta
@kaletalab.bsky.social
Medical Systems Biology research group - Constraint-based modelling - Modelling of host-microbiome-interactions - Systems Biology of Aging
“Studying Paulinella, scientists hope, will elucidate one of the most fundamental transitions in the history of life on our planet — and possibly give clues to how it might happen elsewhere in the universe. It could also provide practical insights on how to engineer photosynthetic organisms”
In an $80 Motel Room, a Discovery to Shed Light on the Origins of Life
A scrappy science project led to a significant discovery: two new species of a rare organism that could elucidate a fundamental transition in the history of life on our planet.
nytimes.com
Diachronic reuse of Neolithic burial monuments by Bronze Age newcomers in Southwestern Britain by @nikolavukovic.bsky.social et al. www.nature.com/articles/s41...
Diachronic reuse of Neolithic burial monuments by Bronze Age newcomers in Southwestern Britain - Scientific Reports
Scientific Reports - Diachronic reuse of Neolithic burial monuments by Bronze Age newcomers in Southwestern Britain
nature.com
Out Now! Obligate cross-feeding of metabolites is common in soil microbial communities #MicroSky
Obligate cross-feeding of metabolites is common in soil microbial communities
Nature Microbiology, Published online: 24 August 2026; doi:10.1038/s41564-026-02457-6Cultivation-dependent techniques, computational analyses and genome-scale metabolic models show widespread amino acid auxotrophies, suggesting that soil microorganisms exist within integrated ecological metabolic networks.
go.nature.com
New preprint from the lab: The Latent Simplicity of Microbial Ecological Interactions www.biorxiv.org/content/10.6... We're excited about this one. We find that high-order microbial interactions often obey simple linear laws making microbial communities far more predictable than one might expect
Happy to share our new paper in Gut Microbes 🧬 Samer Alban and I developed EcoGS, a genome-scale metabolic modelling tool for predicting ecological interactions between microbes. As first author, I thank Samer, @kaletalab.bsky.social, and all co-authors for the teamwork! doi.org/10.1080/1949...
Genome-scale metabolic models predict diet- and lifestyle-driven shifts of ecological interactions in the gut microbiome
Microbiomes and their host environments form complex, interconnected ecosystems. The microbial species within a microbiome, on the one hand, compete for resources, while on the other hand, they exc...
doi.org
The @erc.europa.eu is providing 2.5 million euros for the “CrypticBenefits” research project at @uni-kiel.de through an Advanced Grant #ERCAdG awarded to Prof. Hinrich Schulenburg. Congratulations to our spokesperson @schulenburglab.bsky.social! More: www.metaorganism-research.com/news/crc-118...
1/ Out today in Science (@science.org): a result a decade in the making, and one that changed how I think about what cells are doing when they grow. We found a bacterium that grows slower than it could. And we found the molecular switch that lets us reverse it.
🫴 Decoupling of global metabolic flux and proteome partitioning in bacteria (Escherchia coli and Bacillus subtilis): Here: 👇 | Science www.science.org/doi/10.1126/... @science.org #subtiwiki
Decoupling of global metabolic flux and proteome partitioning in bacteria
Bacteria regulate homeostatic growth by adjusting proteome composition. In Escherichia coli, this coordination is mediated by guanosine tetraphosphate and pentaphosphate, collectively termed (p)ppGpp,...
science.org
Die #KielerWoche steht vor der Tür und wir präsentieren euch in diesem Jahr drei Science Shows mit vielen spannenden Vorträgen: 📅So, 21.06. 🕖14:00 Uhr 📍Seeburg 📅Mi, 24.06. 🕖13:45 Uhr 📍Junge Bühne im Ratsdienergarten 📅Sa, 27.06. 🕖14:00 Uhr 📍Seeburg (hier alle Vorträge auf Englisch) @uni-kiel.de
My colleague Eike Matthias Wacker has developed our 🦠 metagenome processing pipeline which is now published in Nature Communciations: www.nature.com/articles/s41... It's a modular workflow implemented in nextflow that can combine local and public data from SRA Github: github.com/ikmb/TOFU-MA....
TOFU-MAaPO: fast, scalable and reproducible analysis of large metagenome sequence data from the Sequence Read Archive - Nature Communications
The authors introduce a portable, automated single-command Nextflow pipeline for large scale analysis of metagenomic short-read sequencing data. It makes large metagenome projects more accessible to i...
nature.com
Very excited to share our new paper out in Nature. Congrats to Xiaoqian (Annie) Yu and all the coauthors. www.nature.com/articles/s41...
Genome-wide sweeps create ecological units in the human gut microbiome - Nature
Genome-wide selective sweeps commonly occur in the human gut microbiome and can spread across the world within decades to produce epidemic-like population structures.
nature.com
Fascinating new insights into genetic history of Indigenous peoples of America indicate at least three dispersals into South America and striking allele sharing with Australasian populations 🧪 www.nature.com/articles/s41...
Really enjoyed this essay/review on the host microbiome through the lens of island biology. Great explanations, and a very good read throughout. www.sciencedirect.com/science/arti...
Interesting read on the challenges and paradigms for analysing the microbiome in infectious and NCDs www.cell.com/trends/micro...
Premnath Madanagopal joined the group as PhD student in a collaborative project within @spp2474.bsky.social - welcome Prem! 🎉 Looking forward to some exciting insights into microbial metabolic interactions!
What is the status of the Blue Zones 25 years after they were claimed? @shelleywood.bsky.social and I did an extensive look into this question, one of the forces behind the current longevity movement @statnews.com www.statnews.com/2026/05/04/a...
Are blue zones real? Answering that question is harder than ever
"Blue zones" as a concept have strayed far and wide from their humble roots, write Shelley Wood and Eric Topol.
statnews.com
www.cell.com/fulltext/S00... Check this. Great perspective on gene regulation. Thank u @arjunraj.bsky.social
Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences
Gene expression is a fundamentally stochastic process, with randomness in transcription and translation leading to cell-to-cell variations in mRNA and protein levels. This variation appears in organis...
cell.com
Growth costs of suboptimal protein allocation in nonlinear models of growing cells doi.org/10.64898/202...
"Tell me who your friends are, and I’ll tell you who you are." It turns out, microbes follow the same rule! Very proud to share our lab's new paper in @natmicrobiol.nature.com showing that bacteria don't just respond to their environment, they respond to each other. www.nature.com/articles/s41...
Community context reshapes microbial proteomes and reduces functional overlap - Nature Microbiology
Biotic interactions modulate protein abundance, reducing functional redundancy and increasing productivity in complex bacterial communities.
nature.com
Excited to see this work out! 💩🍨🐁 "If you give a mouse a poopsicle: a novel fecal microbiota transplant method for exploring the role of the gut microbiome in stress-related outcomes in mice" www.frontiersin.org/journals/imm... @isbscience.org @uwnews.uw.edu 🧵...
Frontiers | If you give a mouse a poopsicle: a novel fecal microbiota transplant method for exploring the role of the gut microbiome in stress-related outcomes in mice
BackgroundThe microbiome-gut-brain axis is a mediator of stress-related disorders. The number of preclinical studies exploring the potential causal mechanism...
frontiersin.org
We've known the gut-brain axis is a key underpinning of Parkinson's disease. Today, for the 1st time, a gut microbiome signature denoting risk found in healthy individuals with genetic predisposition nature.com/articles/s41...
Microbiome signature of Parkinson’s disease in healthy and genetically at-risk individuals - Nature Medicine
Microbiome analysis suggests that gut microbial changes in Parkinson’s disease evolve progressively from healthy individuals to genetically at-risk individuals to clinically affected patients, with th...
nature.com
🧵 Our new paper is out today in molecularcell.bsky.social! After 7 years of a truly intriguing discovery journey, we can finally share what controls how molecules move inside living E. coli cells. Spoiler: it's not what the field thought. A thread 👇 📄 doi.org/10.1016/j.molcel.2026.03.018
The lab of Johannes Zimmermann at Jena University has an opening for a PhD position - exciting research in a highly innovative group: www.jsmc-phd.de/admission/va...
All currently approved antibiotics inhibit essential cellular processes. Ever wonder if we could kill bacteria using the opposite strategy? Here, we demonstrate an alternative antibacterial strategy: lethality through pathway over-activation. www.nature.com/articles/s41... (1 out of 3)
Activation of l-histidine biosynthesis as a new antibiotic strategy against Mycobacterium tuberculosis - Nature Communications
Here, the authors report metabolic activation as a potential antimicrobial strategy against Mycobacterium tuberculosis. They show that supra-physiological activation of L-histidine biosynthesis r...
nature.com
Cool new study in Nat Comm by Amanda Dugan, Deepsing Syangtan, et al that identifies INTELECTIN-2 as a broad-spectrum antimicrobial operating right at mucosal surfaces INTELECTIN-2 not only senses microbes, it actively shapes which microbes gets to stay 🧵 (1/5) @natcomms.nature.com
You can also find the full paper here: rdcu.be/e74Ou 📄 As my first study as a senior author, this marks an important milestone—and the starting point for many new projects, directions, and ideas 🚀
Dietary patterns influence the in silico GABA production capacity of Bifidobacterium adolescentis HD17T2H and other human gut bacteria
Scientific Reports - Dietary patterns influence the in silico GABA production capacity of Bifidobacterium adolescentis HD17T2H and other human gut bacteria
rdcu.be
Christoph Kaleta@kaletalab.bsky.social · 7mo agoCan diet shape your microbiome’s ability to produce neuroactive compounds? Our latest study shows dietary patterns influence in silico GABA production capability by Bifidobacterium adolescentis and other gut bacteria. Led by Ann Homscheid and @maringos.bsky.social. doi.org/10.1038/s415...
Can diet shape your microbiome’s ability to produce neuroactive compounds? Our latest study shows dietary patterns influence in silico GABA production capability by Bifidobacterium adolescentis and other gut bacteria. Led by Ann Homscheid and @maringos.bsky.social. doi.org/10.1038/s415...
Dietary patterns influence the in silico GABA production capacity of Bifidobacterium adolescentis HD17T2H and other human gut bacteria - Scientific Reports
Gamma-aminobutyric acid (GABA) is a neurotransmitter that inhibits neuronal excitability and also affects mucosal function and gut motility. Importantly, while the gut microbiome is a known source of ...
doi.org
Dogs evolved to eat your leftovers! Comparing dog & wolf genomes revealed dogs have up to 30 EXTRA copies of the amylase gene (AMY2B) that helps digest starch. This is a key genomic signature of living alongside humans & table scraps for thousands of years 🐕 www.nature.com/articles/nat... #2026MMM
