Excited to share my PhD paper! In it, we use targeted 2-photon optogenetic stimulation to determine how V1 activity is read-out in a detection task. We found that network influence, not visual coding properties, predicted the impact of ensembles on behavior - contradicting our expectations (1/5).

Neuron@cp-neuron.bsky.social · last yr.

Online now:

Our lab is hoping to hire a long-term lab manager / research associate to help with admin tasks and neuroscience experiments (3-year minimum commitment). bilh.wd1.myworkdayjobs.com/External/job...

Congrats Marta on a very strong effort!

Marta Porniece@martaapp.bsky.social · 10mo ago

1️⃣ 🥳 Thrilled to share that my postdoc work has finally hit the press! www.nature.com/articles/s41... When we started, we didn’t really know what PVH-MC4R neurons do in obesity. Are they still signaling or “dead”? (e.g., does the chronically high leptin alter α-MSH–MC4R signaling?) 🧵👇

NEW: Mark Andermann ( @markandermann.bsky.social)‬ of @harvardmed.bsky.social‬ brings experimental data and computational modeling together to understand cortical reactivations. Watch the video: youtu.be/1N6i7Zi9kXs #NeuroAI2025 #neuroscience #AI #NeuroAI

Offline Cortical Reactivations of Recent Experiences with Mark Andermann

Mark Andermann from Beth Isreal Deaconess Medical Center & Harvard Medical School joined the Frontiers of NeuroAI Symposium on June 6, 2025, to discuss "Offl...

youtu.be

Out now in @nathumbehav.nature.com: Cuts to NIH funding will impact the economy and employment nationwide. We visualize these losses and advocate for a theory-driven approach to communicating local, self-relevant impact. w/ @joshuasweitz.bsky.social + SCIMaP team: www.nature.com/articles/s41...

NIH indirect cost cuts will affect the economy and employment - Nature Human Behaviour

Nature Human Behaviour - NIH indirect cost cuts will affect the economy and employment

nature.com

Wild! Stephen, Praneel and their team use fluorescence lifetime imaging and various manipulations to show that, in male mice, both mating drive and hypothalamic tonic dopamine release drop after a successful mating and gradually recover over the next week, paralleling the recovery in sperm count.

Praneel Sunkavalli@praneelsunkavalli.bsky.social · last yr.

I am excited to share our preprint on how hypothalamic dopamine neurons govern slow changes in motivation over days! Below are our findings: www.biorxiv.org/content/10.1...

Disruption of visual cortical activity and offline reactivations of recent salient experience in the hours following training on a task associating cues with outcomes completely blocks across-day learning! Exciting work by Kristian, Marianne and their team!

Kristian Lensjø@klensj.bsky.social · last yr.

New paper out with @hafting.bsky.social and @markandermann.bsky.social lab on reactivations and memory consolidation : www.science.org/doi/10.1126/...

We previously showed that specific hypothalamic neurons get more and more activated by each bite of food until they put a brake on homeostatic feeding. Here, we find that this brake is already on at the start of a meal in obese mice on a high-fat diet. Congrats to Marta, Stephen and the whole team!

Marta Porniece@martaapp.bsky.social · last yr.

🚨 Paper alert! 📣 We found abnormal feeding-related neural responses in satiety-promoting, MC4R-expressing neurons in the mouse paraventricular hypothalamus (PVH-MC4R) following diet-induced obesity. www.biorxiv.org/cgi/content/... ​​ #obesity #feedingbehaviour #obesityresearch #neuroscience

Academic workers across the country are calling 📞 Legislators to ask them to sign on to bipartisan letters ✉️ in support of robust NIH funding and opposing the 15% indirect cost caps. Take 5 minutes to call your legislators today. Deadline is May 19th. docs.google.com/document/d/1...

A drop of milkshake takes a wild ride as it passes through the body. Rachel and Kiersten and the team came up with cool strategies for visualizing food passing through the mouse GI tract and mapping the activity of the same 100s of brainstem neurons across weeks during feeding and other behaviors.

Rachel Essner@rachelessner.bsky.social · last yr.

I’m so excited to share our preprint on how brainstem neurons sense and integrate multiple body signals during food consumption. We imaged 1000s of neurons across the lateral parabrachial nucleus (LPBN) in behaving mice. www.biorxiv.org/content/10.1...

🚨iGluSnFR4 is finally out!🚨🧪 We present iGluSnFR4f and 4s, a novel pair of genetically-encoded glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain. ⬇️ www.biorxiv.org/content/10.1... 🎥 Below: iGluSnFR4s detecting minis in cultures w/ TTX #Neuroscience

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024. That's not to mention the countless lives that biomedical research has saved. Show me a better investment than that. www.forbes.com/sites/michae...

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report

National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

forbes.com

Don't miss the final opportunity to showcase your research with a poster presentation at Interoception at the @alleninstitute.bsky.social! Submit by March 4 (11:59pm MST). keysym.us/KSInterocept... youtu.be/424TJ_VTUCI #KSInteroception25 @markandermann.bsky.social @ruimcosta.bsky.social

Interoception Promo Video

YouTube video by KeystoneSymposia

youtu.be

Join us! Science Homecoming helps scientists reconnect with communities by writing about the importance of science funding in their hometown newspapers. We’ve mapped every small newspaper in the U.S. and provide resources to get you started. Help science get back home 🧪🔬🧬 🏠 sciencehomecoming.com

Stand Up for Science rally, March 7, 12-4 pm, Boston Common. Better than moping. www.eventbrite.com/e/stand-up-f...

We lack tools to rapidly track >1-2 changing signals in brain fluids. Peter Kalugin and an amazing team begin to address this challenge with simultaneous, real-time tracking of many (10+) neuromodulatory signals using Multiplexed Optical Recording of Sensors on a micro-Endoscope. Feedback welcome!

@pnkalugin.bsky.social · 2y ago

I’m thrilled to share our preprint presenting MORSE: a new way to simultaneously & quantitatively track patterns of neuromodulators/neuropeptides in vitro & in vivo using spatially multiplexed 3D imaging of 10+ green optical sensors on a microendoscope biorxiv.org/content/10.1101/2025.01.26.634931v1

Absolute measurement of fast and slow neuronal signals with fluorescence lifetime photometry at high temporal resolution https://www.biorxiv.org/content/10.1101/2025.01.10.632162v1

Eight days left to submit your abstract for the 2025 Keystone Symposium on Brain Body Communication at the Allen Institute for Brain Science in Seattle! Join us in exploring the latest in interoception research. Please repost, thanks!

Mark Andermann@markandermann.bsky.social · 2y ago

Happy holidays! For those interested in brain body communication, the Keystone Symposium abstract deadline is approaching. I hope to see some of you soon!

Happy holidays! For those interested in brain body communication, the Keystone Symposium abstract deadline is approaching. I hope to see some of you soon!

Mark Andermann@markandermann.bsky.social · 2y ago

Come explore emerging research in brain-body communication @KeystoneSymp Interoception: Neural Sensing and Control of Organ Function, this April in Seattle! keysym.us/KSInterocept... #KSInteroception25 pic.x.com/gWsgQgcAJh

The choroid plexus actively recruits immune cells during inflammation, according to a new study. By @claudia-lopez.bsky.social www.thetransmitter.org/neuroinflamm...

Stephen Zhang and the team found that in vivo peptide release and signaling gradually enhances responses of satiety-promoting hypothalamic neurons to each bite of food. These consequences of each bite take minutes to manifest, and could help explain why slow eating enhances satiety. rdcu.be/dZlI3

Stochastic neuropeptide signals compete to calibrate the rate of satiation

Nature - Release of hunger-promoting and satiety-promoting neuropeptides drives opposing changes in the second messenger cAMP in awake mouse paraventricular hypothalamic MC4R neurons, thereby...

rdcu.be

Come explore emerging research in brain-body communication @KeystoneSymp Interoception: Neural Sensing and Control of Organ Function, this April in Seattle! keysym.us/KSInterocept... #KSInteroception25 pic.x.com/gWsgQgcAJh