We were pleased to contribute to this important study led by Michael Zech (Munich), in collaboration with Roberto Steiner (Padova/KCL), linking de novo mutations that disrupt kinesin-1 cargo recognition to the neurological movement disorder dystonia. www.thelancet.com/journals/ebi...

Trio analysis in dystonia identifies de novo KLC1 variants in a kinesinopathy with distinct motor and neurodevelopmental features

Our research supports the existence of a kinesinopathy linked to KLC1, featuring phenotypic overlap with diseases related to mutational defects of key interactors of KLC1. The full dystonia de-novo va...

thelancet.com

So great to see badass dynein assembly man Girish Mali @dyneinassembly.bsky.social amongst the Lister Prize winners joining our small but amazing motors subgroup with @simonbullock11.bsky.social @markdodding.bsky.social Viki Allan @susanagodinho.bsky.social Looking forward to seeing all in September

The Lister Institute of Preventive Medicine@thelisterinstitute.bsky.social · 2mo ago

We are more than delighted to welcome our new #ListerPrize2026 Fellows! These eight inspiring researchers are set to pursue ambitious biomedical science, thanks to our flexible funding. Bravo! 👏 Meet the new #ListerFellows (read thread) and repost ⤵️ lister-institute.org.uk/news/our-lis...

🚨 New paper alert 🧬 Our work from the @michellepeckham.bsky.social lab is now out in #ScienceAdvances. We present the #cryoEM structure of shutdown human non-muscle myosin 2A, showing how ionic interactions stabilise auto-inhibition and how mutations disrupt this state. 👉 tinyurl.com/4de8teyh

Two manuscripts from the lab to catch up upon exploring aspects kinesin-1 regulation. First, our examining the role of cargo-adaptor binding in controlling kinesin-1 conformational dynamics and association with MAP7 is now a VOR @elife.bsky.social elifesciences.org/articles/109...

Kinesin-1 conformational dynamics are controlled by a cargo-sensitive TPR switch

Cargo-adaptor binding to the KLC-TPR domains binding triggers structural rearrangements that relieve kinesin-1 autoinhibition, enabling MAP7 recruitment, through an allosteric mechanism that connects ...

elifesciences.org

New preprint on kinesin inhibition and activation - collaborative effort across Bristol Biochem and Chemistry with Woolfson and Schaffizel labs and JJ Phillips in Exeter 1/2 www.biorxiv.org/content/10.1...

Molecular mechanism for cargo-mediated initiation of kinesin-1 activation

Kinesin-1 is a dynamic heterotetrameric assembly of two heavy and two light chains (KHC and KLC) that mediates microtubule-based intracellular transport of many different cargoes. The complex adopts a...

biorxiv.org

We have a new 4-year postdoctoral position available working between our lab at the Woolfson lab at Schools of Biochemistry and Chemistry at Bristol. Applying protein design approaches to control intracellular transport. More info on link and flyer. Get in touch! www.bristol.ac.uk/jobs/find/de...

The position is either funded by a UoB scholarship or SWBio DTP - to be considered for both pools of funding apply separately for each of these. Secondary sup. is the brilliant @markdodding.bsky.social. 📧 E-mail Ferdos.abidali@bristol.ac.uk for informal enquiries & 📝apply here tinyurl.com/yvzeb2kw.

Funded PhD- Coordination Between Actin and Microtubule Motors During Endocytosis at University of Bristol on FindAPhD.com

PhD Project - Funded PhD- Coordination Between Actin and Microtubule Motors During Endocytosis at University of Bristol, listed on FindAPhD.com

tinyurl.com

Please share this PhD opportunity in my new lab in Bristol, using protein design/ engineering to understand and build molecular motors to control intracellular transport. Working with @markdodding.bsky.social and Prof Dek Woolfson. www.findaphd.com/phds/project... www.swbio.ac.uk/biomolecular...

We have three PhD projects with motor-cytoskeleton theme though collaborations with three new(ish) PIs at Bristol Biochemistry supported by SWBio_DTP with Berni Carroll (lysosome transport), @abidalilab.bsky.social (endocytosis) and Jessica Cross (protein design) see swbio.ac.uk/biomolecular...