Accumulation of mucosal and lymphoid hypo-functional granzyme K producing CD8+ effector memory T cells in idiopathic pulmonary fibrosis from @markesnyder.bsky.social www.mucosalimmunology.org/article/S193...
Congratulations to Dr Okereke! Here she presents our work showing the accumulation of granzyme k+ cd8 T cells in the lungs and lung draining lymph nodes of patients with end stage IPF. www.mucosalimmunology.org/article/S193...
Accumulation of mucosal and lymphoid hypo-functional granzyme K producing CD8+ effector memory T cells in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis is a progressive lung disease characterized by the rapid scarring of the lung parenchyma resulting in impaired gas exchange and early mortality. Current treatment options...
mucosalimmunology.org
🌟Congratulations to Charles S. Dela Cruz, MD, PhD, ATSF, recipient of the Senior Level Peer Recognition Award of his outstanding leadership and research contributions in pulmonary and critical care medicine. Learn more: site.thoracic.org/membership/a... @ats-pitb.bsky.social
Rachel A. Gottschalk @gottschalklab.bsky.social, Satarupa Ganguly @satarupa2025.bsky.social & team show lung macrophages lacking GATA2 during inflammation promote metabolic dysfunction & profibrotic gene expression in mice: doi.org/10.1172/jci....
From earlier this week: Immune checkpoint inhibitor therapies for cancer can induce unintended immune related adverse events (irAEs). Here, Deepak A. Rao & team identify T cell features in pre-treatment blood samples that are associated with irAEs after ICI therapy: doi.org/10.1172/jci....
Integrated human and mouse single-cell profiling reveals immune-stromal niche driving silicosis www.mucosalimmunology.org/article/S193...
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 @nature.com @the-de-lab.bsky.social www.nature.com/articles/s41...
Regulatory T cells protect against aberrant remodeling in a mouse model of pulmonary fibrosis from Michael Beers @westphillytough.bsky.social and colleagues: www.mucosalimmunology.org/article/S193...
Diminished T cell immunity during aging can have profound effects on responses to vaccines, cancer immunotherapy and infection. This article describes a unique way to enhance T cell immunity in mice, which could someday be translated to humans. #Science 🧪
Transient hepatic reconstitution of trophic factors enhances aged immunity - Nature
Using lipid nanoparticle delivery of mRNAs to the liver in aged mice, T cell function and declining immune cues can be restored.
nature.com
Imagine this: 20+ years from now. I’m a burnt out scientist, PI of a lab, but forced to work in an ancillary building, filled with reject scientists that have been shunned by the scientific community. Despite this, we end up lucking into groundbreaking fundamental scientific truths. -“Flow Horses”
fit.it
A new mechanism helps explain idiopathic pulmonary fibrosis Preeti Yadav et al. discover crosstalk between myeloid cells and fibroblasts increases ARG1, driving pathologic collagen expression via the production of ornithine in mouse models & human tissue. www.jci.org/articles/vie...
Great manuscript below. Would be amazing if this could be applied to transplantation tolerance. www.science.org/doi/10.1126/...
Generating functionally stable and antigen-specific Treg cells from effector T cells for cell therapy of inflammatory diseases
Antigen-specific and functionally stable Treg cells can be generated in vitro from effector/memory T cells for cell therapy of inflammatory diseases.
science.org
We need an HHS Secretary who respects science and does not make policy based on conspiracy theories. Vaccines are safe and effective. Kennedy is threatening the health of our kids and all Americans. He must resign.
“What are we doing?”🔥 😳🇺🇸 Full: www.instagram.com/reel/DMa31OX...
Memory CD8+ T cells have differential cytotoxic capacities across human tissues @sciimmunology.bsky.social www.science.org/doi/10.1126/...
Donor-recipient SIRPα mismatch, implicated in innate allorecognition and monocyte activation, adversely affects kidney allograft survival in humans www.science.org/doi/10.1126/...
There are a lot of terrible things happening right now, so it’s easy to lose track of page 2+ of the news, but this anti-science/anti-health/pro-idiocy move must be opposed: www.nytimes.com/2025/06/09/h...
Kennedy Removes All C.D.C. Vaccine Panel Experts
nytimes.com
Carl Sagan in 1986 on the problems with media and science literacy.
Run in golden state park. Barely passed this cute banana slug, we were neck and neck for a few miles.
Promoting regenerative responses in a pulmonary fibrosis model! Victor J. Thannickal & team discover that blocking CTLA4 in immune cells induced regeneration and reduce fibrosis in a mouse model of idiopathic pulmonary fibrosis: buff.ly/ZtmORCG
2023 ASCI Emerging-Generation recipient @rramonell.bsky.social identify a novel target to manage treatment-refractory asthma by describing a significant association of airway CD8+ TEMRA cells with asthma duration: buff.ly/gmsfzyQ
Bottom right. Future scientist (or artist, or both) Liam Snyder. Grade 5!
JCI insight@insight.jci.org · last yr.Our current issue's special collection of Physician-Scientist Development articles includes an editorial by Editor in chief @eickelbergmd.bsky.social & is paired with a cover collage of children's drawings illustrating what a 'physician-scientist' means to them: buff.ly/kQ4fmrg
Just got back from the Smokies! Felt amazing to get off the grid for a few seconds.
De Sousa, Perkey, Le Corre, Maillard, Labrecque et al. @umontreal.ca show that fibroblastic reticular cells are the source of Notch ligands promoting the differentiation of short-lived effector CD8+ T cells. rupress.org/jem/article/... #InfectiousDisease #HostDefense #LymphocyteBiology
Maintenance of graft tissue-resident Foxp3+ cells is necessary for lung transplant tolerance in mice www.jci.org/articles/vie... @jclinical-invest.bsky.social
@markesnyder.bsky.social et al. flip the script on our understanding of infection and rejection after transplantation– they show that systemic NKG2D blockade can impair airway-associated Tissue resident memory T cell accumulation and reduce CLAD severity: buff.ly/61mpbwk
