Masschelein Lab

@masscheleinlab.bsky.social

Engineering Microbes for Drug Discovery & Lead Optimization | Exploring the Biosynthetic Creativity of Microorganisms @VIB @KU Leuven -- www.masscheleinlab.org

Oral abstract submissions are open for Directing Biosynthesis VIII! Themes include • genetics, enzymology & structural biology of natural product biosynthesis • genome & microbiome mining • synthetic biology & metabolic/microbiome engineering • chemical ecology • biocatalysis .... 👉 lnkd.in/eT_6rpBZ

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Polyunsaturated fatty acid (PUFA) synthase enzymes turn out to be far more versatile than we ever imagined! In our new preprint, we reveal a largely untapped biosynthetic space where they team up with PKSs and NRPSs to create new types of bioactive amphiphilic metabolites. 👉http://bit.ly/4hzUUak

Charting the biosynthetic landscape of hybrid polyketide-nonribosomal peptide-specialized lipids

Polyunsaturated fatty acid (PUFA) synthase-like enzymes are best known for their role in membrane lipid biosynthesis in marine bacteria, but have also been repurposed for the assembly of specialized l...

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🚨 Tired of redundant #BiosyntheticGeneCluster hits? 💥 Check out #CAGEcleaner – our new genome-level dereplication pipeline for BGC mining and comparative analysis. Works with cblaster & CAGECAT. Now out in Bioinformatics: bit.ly/3TghJEx 🔗 GitHub: bit.ly/44rNZK9 🙌 Kudos to our PhD student Lucas!

CAGEcleaner: reducing genomic redundancy in gene cluster mining

AbstractMotivation. Mining homologous biosynthetic gene clusters (BGCs) typically involves searching colocalised genes against large genomic databases. How

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The new #antiSMASH v8 paper is out in @narjournal.bsky.social! It was a pleasure helping to improve the detection of bacterial polyyne biosynthetic gene clusters. Happy mining! 🧬🔍

Tilmann Weber@tilmweber.bsky.social · last yr.

We're happy to announce that the #antiSMASH v8 paper is out in @narjournal.bsky.social: academic.oup.com/nar/advance-... Many thanks to @kblin.bsky.social, @marnixmedema.bsky.social and many international collaborators!

We are so happy to share that the 2nd Emerging Microbial Technologies conference will take place in Gent next 25th April 2025!! This edition is jointly organized by CMET_UGENT and YBSMicrobiology Follow us also on LinkedIn and X @EMT_conference

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🎄✨ Festive vibes at our annual lab Christmas dinner! Great food and lots of laughter to wrap up a wonderful year of science and teamwork. Here's to more discoveries and collaborations in the year ahead! 🧫🔬

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