Five mutational “fingerprints” could help predict how visible tumours are to the immune system

Researchers from the HUN-REN Szeged Biological Research Centre and HCEMM have just published a new study suggesting that it’s not simply the number of tumour mutations that matters for immunothe...

eurekalert.org

Five dominant amino acid substitution signatures shape tumour immunity - Molecular Systems Biology

Although numerous mutational processes operate in cancer, their functional impacts are unclear. We hypothesised that certain mutation sources preferentially generate amino acid substitutions that evad...

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C > U mutations generate immunogenic peptides in SARS-CoV-2 - Nature Communications

The effect of new viral mutations on T cell responses remains unclear. Here, Balogh et al. show that most new mutations in SARS-CoV-2 are C > U, a bias that leads to an enhanced T cell re...

nature.com

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

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