Great to see a full room at Cornell's Mass Spec Student Society (MS3) proteomics data processing workshop! Participants explored DDA and DIA workflows using FragPipe and DIA-NN. Thanks to @bethylacetate.bsky.social, Herbert, and Yuliang for support, and especially to Katie for the DIA-NN workshop!

Our last two MS3 events at Cornell were a great success! Thanks to BRC Proteomics and Metabolomics Facility for showcasing their services and to @bethylacetate.bsky.social for leading an excellent "Intro to Mass Spec" workshop. Great to see so much enthusiasm. Looking forward to the next workshops!

The first Lunch & Learn panel by the Mass Spectrometry Student Society (MS3) at Cornell was a great success! Full room of students eager to explore mass spec. Huge thanks to everyone who joined, our panelists, and the MS3 team: @bethylacetate.bsky.social, Herbert, Katie, and Yugandhar More to come!

Interested in analyzing kinase activity with subcellular spatial resolution? Want to learn more about peptide barcoding? @smolka-lab.bsky.social and @wjcomstock.bsky.social have something just for you!

Smolka Lab@smolka-lab.bsky.social · 9mo ago

Check out our new biosensor technology to study DDR kinase signaling: ProKAS. We combine: -proteomics -engineered peptide sensors -a new concept of amino acid barcodes ProKAS tracks kinase signaling with spatial resolution and produces highly quantitative data. Just published today: rdcu.be/ePNo0

Check out our new biosensor technology to study DDR kinase signaling: ProKAS. We combine: -proteomics -engineered peptide sensors -a new concept of amino acid barcodes ProKAS tracks kinase signaling with spatial resolution and produces highly quantitative data. Just published today: rdcu.be/ePNo0

Excited to share our new paper from my time in the Skirycz lab (BTI → MSU)! We used co-fractionation MS, including a new untargeted approach we developed, to study protein–metabolite interactions. Co–first author with Jieun Kang — thanks to all involved! www.cell.com/iscience/ful...

Mapping protein-metabolite interactions in E. coli by integrating chromatographic techniques and co-fractionation mass spectrometry

Microbiology; Omics; Metabolomics

cell.com

Honored to receive an Outstanding Poster Award at the Protein Science Symposium! Huge thanks to the @weillinstitute.bsky.social and @weillcornell.bsky.social for an amazing event—and of course, big shoutout to the @smolka-lab.bsky.social for making the poster results possible!

Hope everyone made it home safely after #ASMS2025. Thanks all for making it another fun conference. Planning for #ASMS2026 San Diego started at 7:30am this morning. Don’t forget to fill in the post-conf survey when you get it. More ice cream and fruit? @asms.org

Last day repping @smolka-lab.bsky.social with @wjcomstock.bsky.social at the 73nd(?) #ASMS2025! Had an awesome time—already excited for next year!

#ASMS2025 Thermo User Meeting Thread, starting now. After the corporate message, Ian Mylchreest VP R&D. New products:

New preprint from the lab: ATM controls fork processing and restart, and the PPM1D phosphatase is needed to properly balance this action of ATM. Congratulations to @yitingcao.bsky.social @yingzhengwang.bsky.social and Jumana Badar. www.biorxiv.org/content/10.1...

An ATM-PPM1D Circuit Controls the Processing and Restart of DNA Replication Forks

In response to DNA replication stress, DNA damage signaling kinases inhibit origin firing and promote the remodeling and stabilization of replication forks, leading to a systemic reduction in DNA synt...

biorxiv.org

It's always sad to see great people leave the lab. Jen, our undergraduate lab member, has finished her degree and her honors thesis. It's been a pleasure working with you, Jen! All the best in your future career!

I'm honored to have received the George P. Hess Award from the MBG department and the Outstanding Graduate Teaching Award from CALS. These recognitions wouldn't have been possible without the support of the incredible @smolka-lab.bsky.social and the exceptional students of BIOMG3320.

My first-author paper on uncovering a non-canonical Tel1 motif using phosphoproteomics has been published in JBC! Amazing to work with @rainshj.bsky.social using both untargeted and targeted mass spectrometry. Check it out: doi.org/10.1016/j.jb...

Excited to share our preprint reporting a completely new approach to study kinase signaling: ProKAS. ProKAS is based on a tandem array of peptide sensors with barcodes for multiplexed, spatial and kinetic applications. We applied it to DDR kinases. Please share. www.biorxiv.org/content/10.1...