Here is the work of Jingyi Hu and David Moraga graduate students in my lab, published online in Plos Genetics journals.plos.org/plosgenetics...

Potential Rad54 separation of function mutation highlights unique roles during homologous recombination

Author summary Homologous recombination (HR) is a DNA double-strand break repair pathway that functions at DNA breaks and stalled or collapsed replication forks. Rad51 is a critical enzyme that mediat...

journals.plos.org

Today we are very pleased to share our latest article available now online @narjournal.bsky.social about the role of Slx4 scaffold and Fun30 (SMARCAD1 homolog) in DNA damage response regulation and replication fork protection against Top1-DNA crosslinks. academic.oup.com/nar/article/...

Check out our new biosensor technology to study DDR kinase signaling: ProKAS. We combine: -proteomics -engineered peptide sensors -a new concept of amino acid barcodes ProKAS tracks kinase signaling with spatial resolution and produces highly quantitative data. Just published today: rdcu.be/ePNo0

A significant conceptual advance in the field of DNA recombination… great work by the labs of @brookscrickard1.bsky.social and Michelle Wang

@brookscrickard1.bsky.social · 11mo ago

Just throwing this out there as a significant conceptual advance in the field www.biorxiv.org/content/10.1...

Honored to receive an Outstanding Poster Award at the Protein Science Symposium! Huge thanks to the @weillinstitute.bsky.social and @weillcornell.bsky.social for an amazing event—and of course, big shoutout to the @smolka-lab.bsky.social for making the poster results possible!

We are counting down the days to our Protein Science Symposium on June 10-12! Thrilled to be hosting our colleagues from WCM @weillcornell.bsky.social as well as keynote speakers Dr. Christopher Lima @christopherdlima.bsky.social and Dr. ‪Jin Zhang @jinzhanglab.bsky.social

New preprint from the lab: ATM controls fork processing and restart, and the PPM1D phosphatase is needed to properly balance this action of ATM. Congratulations to @yitingcao.bsky.social @yingzhengwang.bsky.social and Jumana Badar. www.biorxiv.org/content/10.1...

An ATM-PPM1D Circuit Controls the Processing and Restart of DNA Replication Forks

In response to DNA replication stress, DNA damage signaling kinases inhibit origin firing and promote the remodeling and stabilization of replication forks, leading to a systemic reduction in DNA synt...

biorxiv.org

Double award to the fantastic graduate student @mateuszwagner.bsky.social …

Mateusz Wagner@mateuszwagner.bsky.social · last yr.

I'm honored to have received the George P. Hess Award from the MBG department and the Outstanding Graduate Teaching Award from CALS. These recognitions wouldn't have been possible without the support of the incredible @smolka-lab.bsky.social and the exceptional students of BIOMG3320.

Devasting that clinical trial for Jim's PediaFlow baby heart pump is on hold due the stop on all DOD funding at Cornell. Funded by DOD CDMRP, Congressionally Directed Medical Research Programs, yet White House stopped Congress funds #ResearchSavesLives #Standup4Science youtu.be/a7aUBvBcPV4

Research at Risk: Life-saving heart pumps for babies

YouTube video by Cornell University

youtu.be

🚨🧪 Are you a researcher affected by the recent cancellation of federal grants and contracts at Columbia University? I'm working on a story for @Nature.com. If you want to chat, your identity will be kept private. Signal: humbertobasilio.24 Email: humberto.basilio@us.nature.com Repost please!

Our preprint is now published www.science.org/doi/10.1126/...

Telomeric transposons are pervasive in linear bacterial genomes

Eukaryotes have linear DNA and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. Here we identify several families of independently evolved telomeric tr...

science.org

Joe Peters Lab@joepeterslab.bsky.social · 2y ago

Eukaryotes have linear DNA and their telomeres are hotspots for transposons. Many bacteria are also known to have linear chromosomes and plasmids. We identified several families of independently evolved telomeric transposons in cyanobacteria and Streptomyces. 1/7 www.biorxiv.org/content/10.1...

Applications are open for the Weill Institute Emerging Scholars Symposium @ Cornell! Senior PhD students and, now, postdocs interested in networking & presenting their work in cell & molecular biology should apply by April 14, 2025. Please repost! wicmb.cornell.edu/emerging-sch...

Senior graduate students and postdocs, here is a great opportunity to network, showcase your science and get to know Cornell and beautiful Ithaca! Please repost.

Jeremy Baskin@jeremybaskin.bsky.social · last yr.

Some good news: applications are open for the Weill Institute Emerging Scholars Symposium @ Cornell! Senior PhD students and, now, postdocs interested in networking & presenting their work in cell & molecular biology at Cornell should apply by Apr 14. Please repost! wicmb.cornell.edu/emerging-sch...

My first-author paper on uncovering a non-canonical Tel1 motif using phosphoproteomics has been published in JBC! Amazing to work with @rainshj.bsky.social using both untargeted and targeted mass spectrometry. Check it out: doi.org/10.1016/j.jb...

Very interesting work by the @zhalab.bsky.social showing why Ku is essential in human cells

Zha Lab@zhalab.bsky.social · last yr.

Exciting results! Using AID-Degron system, Dr. Yimeng Zhu in the lab found that Ku suppresses RNA-mediated innate immunity to accommodate Alu-expansion in primates - solving the misery of Ku essentiality in human cell and uncover 94r^2 for co evolution www.biorxiv.org/content/10.1...

In this new paper we find that Tel1 kinase (yeast ATM) targets D/E-S/T motifs… more prevalent than S/T-Q! Mec1 (yeast ATR) can’t target D/E-S/T, so we think D/E-S/T targeting allows Tel1 functional specialization. A mutation in Tel1 makes it only target S/T-Q… and cells become CPT sensitive.

Profiling Tel1 Signaling Reveals a Non-Canonical Motif Targeting DNA Repair and Telomere Control Machineries

The stability of the genome relies on Phosphatidyl Inositol 3-Kinase-related Kinases (PIKKs) that sense DNA damage and trigger elaborate downstream si…

sciencedirect.com

Happy to share a new work from the lab on how DNA damage checkpoint can be down-regulated. rdcu.be/d5o3E. Congrats to all authors at @mskcancercenter.bsky.social and our Weill BCMB student @tzippora.bsky.social. gradschool.weill.cornell.edu/bcmb-allied-...

Excited to share our preprint reporting a completely new approach to study kinase signaling: ProKAS. ProKAS is based on a tandem array of peptide sensors with barcodes for multiplexed, spatial and kinetic applications. We applied it to DDR kinases. Please share. www.biorxiv.org/content/10.1...

Great “tools of the trade” piece by Xiaofu Cao in Nat Rev Mol Cell Biol about her recent paper exploiting cell cycle-dependent phosphorylation to make a conditional protein relocalization tool! ToT piece: rdcu.be/d0Utp Original paper (@naturecellbiology.bsky.social): www.nature.com/articles/s41...

Exploiting cell cycle-dependent dephosphorylation for mitosis-specific protein recruitment

Nature Reviews Molecular Cell Biology - In this Tools of the Trade article, Cao (Baskin lab) discusses the development of MARS, which enables mitosis-specific recruitment of enzymes to the plasma...

rdcu.be